Identification of Shiga-Toxin-Producing Shigella Infections in Travel and Non-Travel Related Cases in Alberta, Canada

It has long been accepted that Shiga toxin (Stx) only exists in Shigella dysenteriae serotype 1. However, in recent decades, the presence of Shiga toxin genes (stx) in other Shigella spp. have been reported. We screened 366 Shigella f...

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Autores principales:	Shuai Zhi, Brendon D. Parsons, Jonas Szelewicki, Yue T. K. Yuen, Patrick Fach, Sabine Delannoy, Vincent Li, Christina Ferrato, Stephen B. Freedman, Bonita E. Lee, Xiao-Li Pang, Linda Chui
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Shigella flexneri</i> Shiga toxin phage phylogenomic global transmissions Medicine R
Acceso en línea:	https://doaj.org/article/34d8d435e8e8459fac7d17d86616b65f
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spelling	oai:doaj.org-article:34d8d435e8e8459fac7d17d86616b65f2021-11-25T19:08:35ZIdentification of Shiga-Toxin-Producing Shigella Infections in Travel and Non-Travel Related Cases in Alberta, Canada10.3390/toxins131107552072-6651https://doaj.org/article/34d8d435e8e8459fac7d17d86616b65f2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6651/13/11/755https://doaj.org/toc/2072-6651It has long been accepted that Shiga toxin (Stx) only exists in <i>Shigella dysenteriae</i> serotype 1. However, in recent decades, the presence of Shiga toxin genes (<i>stx</i>) in other <i>Shigella</i> spp. have been reported. We screened 366 <i>Shigella flexneri</i> strains from Alberta, Canada (2003 to 2016) for <i>stx</i> and 26 positive strains were identified. These isolates are highly related with the majority originating from the Dominican Republic and three isolates with Haiti origin. Both phylogenetic and spanning tree analysis of the 26 Alberta and 29 <i>stx</i> positive <i>S. flexneri</i> originating from the U.S., France, Canada (Quebec) and Haiti suggests that there are geographic specific distribution patterns (Haiti and Dominican Republic clades). This study provides the first comprehensive whole genome based phylogenetic analysis of <i>stx</i> positive <i>S. flexneri</i> strains as well as their global transmission, which signify the public health risks of global spreading of these strains.Shuai ZhiBrendon D. ParsonsJonas SzelewickiYue T. K. YuenPatrick FachSabine DelannoyVincent LiChristina FerratoStephen B. FreedmanBonita E. LeeXiao-Li PangLinda ChuiMDPI AGarticle<i>Shigella flexneri</i>Shiga toxinphagephylogenomicglobal transmissionsMedicineRENToxins, Vol 13, Iss 755, p 755 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Shigella flexneri</i> Shiga toxin phage phylogenomic global transmissions Medicine R
spellingShingle	<i>Shigella flexneri</i> Shiga toxin phage phylogenomic global transmissions Medicine R Shuai Zhi Brendon D. Parsons Jonas Szelewicki Yue T. K. Yuen Patrick Fach Sabine Delannoy Vincent Li Christina Ferrato Stephen B. Freedman Bonita E. Lee Xiao-Li Pang Linda Chui Identification of Shiga-Toxin-Producing Shigella Infections in Travel and Non-Travel Related Cases in Alberta, Canada
description	It has long been accepted that Shiga toxin (Stx) only exists in <i>Shigella dysenteriae</i> serotype 1. However, in recent decades, the presence of Shiga toxin genes (<i>stx</i>) in other <i>Shigella</i> spp. have been reported. We screened 366 <i>Shigella flexneri</i> strains from Alberta, Canada (2003 to 2016) for <i>stx</i> and 26 positive strains were identified. These isolates are highly related with the majority originating from the Dominican Republic and three isolates with Haiti origin. Both phylogenetic and spanning tree analysis of the 26 Alberta and 29 <i>stx</i> positive <i>S. flexneri</i> originating from the U.S., France, Canada (Quebec) and Haiti suggests that there are geographic specific distribution patterns (Haiti and Dominican Republic clades). This study provides the first comprehensive whole genome based phylogenetic analysis of <i>stx</i> positive <i>S. flexneri</i> strains as well as their global transmission, which signify the public health risks of global spreading of these strains.
format	article
author	Shuai Zhi Brendon D. Parsons Jonas Szelewicki Yue T. K. Yuen Patrick Fach Sabine Delannoy Vincent Li Christina Ferrato Stephen B. Freedman Bonita E. Lee Xiao-Li Pang Linda Chui
author_facet	Shuai Zhi Brendon D. Parsons Jonas Szelewicki Yue T. K. Yuen Patrick Fach Sabine Delannoy Vincent Li Christina Ferrato Stephen B. Freedman Bonita E. Lee Xiao-Li Pang Linda Chui
author_sort	Shuai Zhi
title	Identification of Shiga-Toxin-Producing Shigella Infections in Travel and Non-Travel Related Cases in Alberta, Canada
title_short	Identification of Shiga-Toxin-Producing Shigella Infections in Travel and Non-Travel Related Cases in Alberta, Canada
title_full	Identification of Shiga-Toxin-Producing Shigella Infections in Travel and Non-Travel Related Cases in Alberta, Canada
title_fullStr	Identification of Shiga-Toxin-Producing Shigella Infections in Travel and Non-Travel Related Cases in Alberta, Canada
title_full_unstemmed	Identification of Shiga-Toxin-Producing Shigella Infections in Travel and Non-Travel Related Cases in Alberta, Canada
title_sort	identification of shiga-toxin-producing shigella infections in travel and non-travel related cases in alberta, canada
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/34d8d435e8e8459fac7d17d86616b65f
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Identification of Shiga-Toxin-Producing Shigella Infections in Travel and Non-Travel Related Cases in Alberta, Canada

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