A triple negative breast cancer: what it is not!

Suresh B KatakkarRegional Medical Oncology Hematology Leader, Centre for the North, BC Cancer Agency, Prince George, British Columbia, CanadaAbstract: The triple negative cancer is an unusual, and at the same time, a unique entity where the discordance rate is almost 18%. That means 18% of Her2 nega...

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Autor principal:	Katakkar SB
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/34d96f55e3a545ba965c23956564a1ec
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id	oai:doaj.org-article:34d96f55e3a545ba965c23956564a1ec
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spelling	oai:doaj.org-article:34d96f55e3a545ba965c23956564a1ec2021-12-02T07:50:02ZA triple negative breast cancer: what it is not!1179-1314https://doaj.org/article/34d96f55e3a545ba965c23956564a1ec2012-02-01T00:00:00Zhttp://www.dovepress.com/a-triple-negative-breast-cancer-what-it-is-not-a9352https://doaj.org/toc/1179-1314Suresh B KatakkarRegional Medical Oncology Hematology Leader, Centre for the North, BC Cancer Agency, Prince George, British Columbia, CanadaAbstract: The triple negative cancer is an unusual, and at the same time, a unique entity where the discordance rate is almost 18%. That means 18% of Her2 negative results will transform into a Her2 positive status and will have the affinity to spread to the central nervous system (CNS). With the identification of CD44, CD24, and ALDH1, we may be able to determine which group of triple negative breast cancer patients will have CNS metastasis. This case illustrates the Her2 expressing cells have higher CNS affinity. As the original tumor was Her2 negative, if a genomic assay was then done on this patient, we would have identified the potential of CNS involvement. In conclusion, genomic assays should be routinely done on triple negative cancers.Keywords: triple negative, breast cancer, claudin high or low, genomic microassayKatakkar SBDove Medical PressarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol 2012, Iss default, Pp 21-23 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Katakkar SB A triple negative breast cancer: what it is not!
description	Suresh B KatakkarRegional Medical Oncology Hematology Leader, Centre for the North, BC Cancer Agency, Prince George, British Columbia, CanadaAbstract: The triple negative cancer is an unusual, and at the same time, a unique entity where the discordance rate is almost 18%. That means 18% of Her2 negative results will transform into a Her2 positive status and will have the affinity to spread to the central nervous system (CNS). With the identification of CD44, CD24, and ALDH1, we may be able to determine which group of triple negative breast cancer patients will have CNS metastasis. This case illustrates the Her2 expressing cells have higher CNS affinity. As the original tumor was Her2 negative, if a genomic assay was then done on this patient, we would have identified the potential of CNS involvement. In conclusion, genomic assays should be routinely done on triple negative cancers.Keywords: triple negative, breast cancer, claudin high or low, genomic microassay
format	article
author	Katakkar SB
author_facet	Katakkar SB
author_sort	Katakkar SB
title	A triple negative breast cancer: what it is not!
title_short	A triple negative breast cancer: what it is not!
title_full	A triple negative breast cancer: what it is not!
title_fullStr	A triple negative breast cancer: what it is not!
title_full_unstemmed	A triple negative breast cancer: what it is not!
title_sort	triple negative breast cancer: what it is not!
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/34d96f55e3a545ba965c23956564a1ec
work_keys_str_mv	AT katakkarsb atriplenegativebreastcancerwhatitisnot AT katakkarsb triplenegativebreastcancerwhatitisnot
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A triple negative breast cancer: what it is not!

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