Calmodulin shuttling mediates cytonuclear signaling to trigger experience-dependent transcription and memory
Activity-dependent gene expression is thought to involve translocation of Ca2+/calmodulin (CaM) to the nucleus. Here, the authors examine a translocation-deficient mutant of γCaMKII, a Ca2+/CaM shuttle protein, to show that translocation of Ca2+/CaM is required for memory and synaptic plasticity.
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| Lenguaje: | EN |
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Nature Portfolio
2018
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| Acceso en línea: | https://doaj.org/article/34dbab589ffe458d93f6a4787c736d3c |
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oai:doaj.org-article:34dbab589ffe458d93f6a4787c736d3c2021-12-02T17:33:16ZCalmodulin shuttling mediates cytonuclear signaling to trigger experience-dependent transcription and memory10.1038/s41467-018-04705-82041-1723https://doaj.org/article/34dbab589ffe458d93f6a4787c736d3c2018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04705-8https://doaj.org/toc/2041-1723Activity-dependent gene expression is thought to involve translocation of Ca2+/calmodulin (CaM) to the nucleus. Here, the authors examine a translocation-deficient mutant of γCaMKII, a Ca2+/CaM shuttle protein, to show that translocation of Ca2+/CaM is required for memory and synaptic plasticity.Samuel M. CohenBenjamin SuutariXingzhi HeYang WangSandrine SanchezNatasha N. TirkoNataniel J. MandelbergCaitlin MullinsGuangjun ZhouShuqi WangIlona KatsAlejandro SalahRichard W. TsienHuan MaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Samuel M. Cohen Benjamin Suutari Xingzhi He Yang Wang Sandrine Sanchez Natasha N. Tirko Nataniel J. Mandelberg Caitlin Mullins Guangjun Zhou Shuqi Wang Ilona Kats Alejandro Salah Richard W. Tsien Huan Ma Calmodulin shuttling mediates cytonuclear signaling to trigger experience-dependent transcription and memory |
| description |
Activity-dependent gene expression is thought to involve translocation of Ca2+/calmodulin (CaM) to the nucleus. Here, the authors examine a translocation-deficient mutant of γCaMKII, a Ca2+/CaM shuttle protein, to show that translocation of Ca2+/CaM is required for memory and synaptic plasticity. |
| format |
article |
| author |
Samuel M. Cohen Benjamin Suutari Xingzhi He Yang Wang Sandrine Sanchez Natasha N. Tirko Nataniel J. Mandelberg Caitlin Mullins Guangjun Zhou Shuqi Wang Ilona Kats Alejandro Salah Richard W. Tsien Huan Ma |
| author_facet |
Samuel M. Cohen Benjamin Suutari Xingzhi He Yang Wang Sandrine Sanchez Natasha N. Tirko Nataniel J. Mandelberg Caitlin Mullins Guangjun Zhou Shuqi Wang Ilona Kats Alejandro Salah Richard W. Tsien Huan Ma |
| author_sort |
Samuel M. Cohen |
| title |
Calmodulin shuttling mediates cytonuclear signaling to trigger experience-dependent transcription and memory |
| title_short |
Calmodulin shuttling mediates cytonuclear signaling to trigger experience-dependent transcription and memory |
| title_full |
Calmodulin shuttling mediates cytonuclear signaling to trigger experience-dependent transcription and memory |
| title_fullStr |
Calmodulin shuttling mediates cytonuclear signaling to trigger experience-dependent transcription and memory |
| title_full_unstemmed |
Calmodulin shuttling mediates cytonuclear signaling to trigger experience-dependent transcription and memory |
| title_sort |
calmodulin shuttling mediates cytonuclear signaling to trigger experience-dependent transcription and memory |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/34dbab589ffe458d93f6a4787c736d3c |
| work_keys_str_mv |
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