ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation
The t(8;21) translocation is often found in acute myeloid leukaemia but is not sufficient for development of the disease. In this study, the authors identify frequent mutations in the transcriptional repressor, ZBTB7A, in these patients and show that the mutations reduce DNA binding activity.
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2016
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oai:doaj.org-article:34dfb0d723444cba95f2984a6162b8c62021-12-02T16:50:14ZZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation10.1038/ncomms117332041-1723https://doaj.org/article/34dfb0d723444cba95f2984a6162b8c62016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11733https://doaj.org/toc/2041-1723The t(8;21) translocation is often found in acute myeloid leukaemia but is not sufficient for development of the disease. In this study, the authors identify frequent mutations in the transcriptional repressor, ZBTB7A, in these patients and show that the mutations reduce DNA binding activity.Luise HartmannSayantanee DuttaSabrina OpatzSebastian VosbergKatrin ReiterGeorg LeuboltKlaus H. MetzelerTobias HeroldStefanos A. BamopoulosKathrin BräundlEvelyn ZellmeierBianka KsienzykNikola P. KonstandinStephanie SchneiderKarl-Peter HopfnerAlexander GrafStefan KrebsHelmut BlumJan Moritz MiddekeFriedrich StölzelChristian ThiedeStephan WolfStefan K. BohlanderCaroline PreissLinping Chen-WichmannChristian WichmannMaria Cristina SauerlandThomas BüchnerWolfgang E. BerdelBernhard J. WörmannJan BraessWolfgang HiddemannKarsten SpiekermannPhilipp A. GreifNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-7 (2016) |
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| language |
EN |
| topic |
Science Q |
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Science Q Luise Hartmann Sayantanee Dutta Sabrina Opatz Sebastian Vosberg Katrin Reiter Georg Leubolt Klaus H. Metzeler Tobias Herold Stefanos A. Bamopoulos Kathrin Bräundl Evelyn Zellmeier Bianka Ksienzyk Nikola P. Konstandin Stephanie Schneider Karl-Peter Hopfner Alexander Graf Stefan Krebs Helmut Blum Jan Moritz Middeke Friedrich Stölzel Christian Thiede Stephan Wolf Stefan K. Bohlander Caroline Preiss Linping Chen-Wichmann Christian Wichmann Maria Cristina Sauerland Thomas Büchner Wolfgang E. Berdel Bernhard J. Wörmann Jan Braess Wolfgang Hiddemann Karsten Spiekermann Philipp A. Greif ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation |
| description |
The t(8;21) translocation is often found in acute myeloid leukaemia but is not sufficient for development of the disease. In this study, the authors identify frequent mutations in the transcriptional repressor, ZBTB7A, in these patients and show that the mutations reduce DNA binding activity. |
| format |
article |
| author |
Luise Hartmann Sayantanee Dutta Sabrina Opatz Sebastian Vosberg Katrin Reiter Georg Leubolt Klaus H. Metzeler Tobias Herold Stefanos A. Bamopoulos Kathrin Bräundl Evelyn Zellmeier Bianka Ksienzyk Nikola P. Konstandin Stephanie Schneider Karl-Peter Hopfner Alexander Graf Stefan Krebs Helmut Blum Jan Moritz Middeke Friedrich Stölzel Christian Thiede Stephan Wolf Stefan K. Bohlander Caroline Preiss Linping Chen-Wichmann Christian Wichmann Maria Cristina Sauerland Thomas Büchner Wolfgang E. Berdel Bernhard J. Wörmann Jan Braess Wolfgang Hiddemann Karsten Spiekermann Philipp A. Greif |
| author_facet |
Luise Hartmann Sayantanee Dutta Sabrina Opatz Sebastian Vosberg Katrin Reiter Georg Leubolt Klaus H. Metzeler Tobias Herold Stefanos A. Bamopoulos Kathrin Bräundl Evelyn Zellmeier Bianka Ksienzyk Nikola P. Konstandin Stephanie Schneider Karl-Peter Hopfner Alexander Graf Stefan Krebs Helmut Blum Jan Moritz Middeke Friedrich Stölzel Christian Thiede Stephan Wolf Stefan K. Bohlander Caroline Preiss Linping Chen-Wichmann Christian Wichmann Maria Cristina Sauerland Thomas Büchner Wolfgang E. Berdel Bernhard J. Wörmann Jan Braess Wolfgang Hiddemann Karsten Spiekermann Philipp A. Greif |
| author_sort |
Luise Hartmann |
| title |
ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation |
| title_short |
ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation |
| title_full |
ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation |
| title_fullStr |
ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation |
| title_full_unstemmed |
ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation |
| title_sort |
zbtb7a mutations in acute myeloid leukaemia with t(8;21) translocation |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/34dfb0d723444cba95f2984a6162b8c6 |
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