DYNAMICS OF CIRCULATING AND EXPRESSED CYTOKINES UPON INDUCTION OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS

Abstract. Experimental allergic encephalomyelitis (EAE) represents an inflammatory demyelinating CNS disease, thus being regarded as an experimental model of multiple sclerosis. The aim of present work was to study production of pro- and anti-inflammatory cytokines, and their expression in spinal co...

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Autores principales:	Yu. L. Zhitnukhin, I. N. Abdurasulova, E. A. Tarasova, D. I. Sokolov, T. A. Novikova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	experimental allergic encephalomyelitis cytokines mrna demyelinization Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/34e1b6245c384964aa5f00a069480c94
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spelling	oai:doaj.org-article:34e1b6245c384964aa5f00a069480c942021-11-18T08:03:38ZDYNAMICS OF CIRCULATING AND EXPRESSED CYTOKINES UPON INDUCTION OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS1563-06252313-741X10.15789/1563-0625-2008-2-3-193-202https://doaj.org/article/34e1b6245c384964aa5f00a069480c942014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/135https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Experimental allergic encephalomyelitis (EAE) represents an inflammatory demyelinating CNS disease, thus being regarded as an experimental model of multiple sclerosis. The aim of present work was to study production of pro- and anti-inflammatory cytokines, and their expression in spinal cord of rats challenged with encephalitis-inducing mixture, in the course of EAE progression. Pathological features of EAE were characterized by meningeal, perivascular, and periventricular infiltration of brain stem, cerebellum and spinal cord. The areas of demyelinization were associated with inflammatory foci, being located at the edges of infiltrates. In sensitized animals, increased levels of serum ТNFα were detectable, being higher in diseased animals, as compared with healthy ones, both in latent phase and during advanced neurological disorder. Increase in circulating IL-10 was in parallel with initial phase of EAE, being also observed in recovering animals. Early increase of IL-10 levels predetermined mild course of the disease, accompanied by decrease in ТNFα activity, whereas low IL-10 levels were registered in severely ill rats with high ТNFα, followed by lethal outcome. ТNFα-specific mRNA was revealed in acute phase of EAE, IL-10 mRNA was detectable at the time of recovery. ТNFα expression was observed for a long time in cases of protracted disease, being, however, absent in EAE-free rats. The data demonstrate that higher levels of ТNFα in blood serum during latent period, and, especially, at later time, may promote development of damage in central nervous system. The central cytokine pool is involved into progression of neurological disorders, thus influencing duration and severity of the disease. (Med. Immunol., 2008, vol. 10, N 2-3, pp 193-202).Yu. L. ZhitnukhinI. N. AbdurasulovaE. A. TarasovaD. I. SokolovT. A. NovikovaSPb RAACIarticleexperimental allergic encephalomyelitiscytokinesmrnademyelinizationImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 10, Iss 2-3, Pp 193-202 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	experimental allergic encephalomyelitis cytokines mrna demyelinization Immunologic diseases. Allergy RC581-607
spellingShingle	experimental allergic encephalomyelitis cytokines mrna demyelinization Immunologic diseases. Allergy RC581-607 Yu. L. Zhitnukhin I. N. Abdurasulova E. A. Tarasova D. I. Sokolov T. A. Novikova DYNAMICS OF CIRCULATING AND EXPRESSED CYTOKINES UPON INDUCTION OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS
description	Abstract. Experimental allergic encephalomyelitis (EAE) represents an inflammatory demyelinating CNS disease, thus being regarded as an experimental model of multiple sclerosis. The aim of present work was to study production of pro- and anti-inflammatory cytokines, and their expression in spinal cord of rats challenged with encephalitis-inducing mixture, in the course of EAE progression. Pathological features of EAE were characterized by meningeal, perivascular, and periventricular infiltration of brain stem, cerebellum and spinal cord. The areas of demyelinization were associated with inflammatory foci, being located at the edges of infiltrates. In sensitized animals, increased levels of serum ТNFα were detectable, being higher in diseased animals, as compared with healthy ones, both in latent phase and during advanced neurological disorder. Increase in circulating IL-10 was in parallel with initial phase of EAE, being also observed in recovering animals. Early increase of IL-10 levels predetermined mild course of the disease, accompanied by decrease in ТNFα activity, whereas low IL-10 levels were registered in severely ill rats with high ТNFα, followed by lethal outcome. ТNFα-specific mRNA was revealed in acute phase of EAE, IL-10 mRNA was detectable at the time of recovery. ТNFα expression was observed for a long time in cases of protracted disease, being, however, absent in EAE-free rats. The data demonstrate that higher levels of ТNFα in blood serum during latent period, and, especially, at later time, may promote development of damage in central nervous system. The central cytokine pool is involved into progression of neurological disorders, thus influencing duration and severity of the disease. (Med. Immunol., 2008, vol. 10, N 2-3, pp 193-202).
format	article
author	Yu. L. Zhitnukhin I. N. Abdurasulova E. A. Tarasova D. I. Sokolov T. A. Novikova
author_facet	Yu. L. Zhitnukhin I. N. Abdurasulova E. A. Tarasova D. I. Sokolov T. A. Novikova
author_sort	Yu. L. Zhitnukhin
title	DYNAMICS OF CIRCULATING AND EXPRESSED CYTOKINES UPON INDUCTION OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS
title_short	DYNAMICS OF CIRCULATING AND EXPRESSED CYTOKINES UPON INDUCTION OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS
title_full	DYNAMICS OF CIRCULATING AND EXPRESSED CYTOKINES UPON INDUCTION OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS
title_fullStr	DYNAMICS OF CIRCULATING AND EXPRESSED CYTOKINES UPON INDUCTION OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS
title_full_unstemmed	DYNAMICS OF CIRCULATING AND EXPRESSED CYTOKINES UPON INDUCTION OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS
title_sort	dynamics of circulating and expressed cytokines upon induction of experimental allergic encephalomyelitis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/34e1b6245c384964aa5f00a069480c94
work_keys_str_mv	AT yulzhitnukhin dynamicsofcirculatingandexpressedcytokinesuponinductionofexperimentalallergicencephalomyelitis AT inabdurasulova dynamicsofcirculatingandexpressedcytokinesuponinductionofexperimentalallergicencephalomyelitis AT eatarasova dynamicsofcirculatingandexpressedcytokinesuponinductionofexperimentalallergicencephalomyelitis AT disokolov dynamicsofcirculatingandexpressedcytokinesuponinductionofexperimentalallergicencephalomyelitis AT tanovikova dynamicsofcirculatingandexpressedcytokinesuponinductionofexperimentalallergicencephalomyelitis
_version_	1718422535050100736

DYNAMICS OF CIRCULATING AND EXPRESSED CYTOKINES UPON INDUCTION OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS

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