Memory-based mismatch response to frequency changes in rats.

Any occasional changes in the acoustic environment are of potential importance for survival. In humans, the preattentive detection of such changes generates the mismatch negativity (MMN) component of event-related brain potentials. MMN is elicited to rare changes ('deviants') in a series o...

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Autores principales:	Piia Astikainen, Gabor Stefanics, Miriam Nokia, Arto Lipponen, Fengyu Cong, Markku Penttonen, Timo Ruusuvirta
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/34e1cc5cda654e7e960b43b1ad63948d
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spelling	oai:doaj.org-article:34e1cc5cda654e7e960b43b1ad63948d2021-11-18T06:46:39ZMemory-based mismatch response to frequency changes in rats.1932-620310.1371/journal.pone.0024208https://doaj.org/article/34e1cc5cda654e7e960b43b1ad63948d2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21915297/?tool=EBIhttps://doaj.org/toc/1932-6203Any occasional changes in the acoustic environment are of potential importance for survival. In humans, the preattentive detection of such changes generates the mismatch negativity (MMN) component of event-related brain potentials. MMN is elicited to rare changes ('deviants') in a series of otherwise regularly repeating stimuli ('standards'). Deviant stimuli are detected on the basis of a neural comparison process between the input from the current stimulus and the sensory memory trace of the standard stimuli. It is, however, unclear to what extent animals show a similar comparison process in response to auditory changes. To resolve this issue, epidural potentials were recorded above the primary auditory cortex of urethane-anesthetized rats. In an oddball condition, tone frequency was used to differentiate deviants interspersed randomly among a standard tone. Mismatch responses were observed at 60-100 ms after stimulus onset for frequency increases of 5% and 12.5% but not for similarly descending deviants. The response diminished when the silent inter-stimulus interval was increased from 375 ms to 600 ms for +5% deviants and from 600 ms to 1000 ms for +12.5% deviants. In comparison to the oddball condition the response also diminished in a control condition in which no repetitive standards were presented (equiprobable condition). These findings suggest that the rat mismatch response is similar to the human MMN and indicate that anesthetized rats provide a valuable model for studies of central auditory processing.Piia AstikainenGabor StefanicsMiriam NokiaArto LipponenFengyu CongMarkku PenttonenTimo RuusuvirtaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 9, p e24208 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Piia Astikainen Gabor Stefanics Miriam Nokia Arto Lipponen Fengyu Cong Markku Penttonen Timo Ruusuvirta Memory-based mismatch response to frequency changes in rats.
description	Any occasional changes in the acoustic environment are of potential importance for survival. In humans, the preattentive detection of such changes generates the mismatch negativity (MMN) component of event-related brain potentials. MMN is elicited to rare changes ('deviants') in a series of otherwise regularly repeating stimuli ('standards'). Deviant stimuli are detected on the basis of a neural comparison process between the input from the current stimulus and the sensory memory trace of the standard stimuli. It is, however, unclear to what extent animals show a similar comparison process in response to auditory changes. To resolve this issue, epidural potentials were recorded above the primary auditory cortex of urethane-anesthetized rats. In an oddball condition, tone frequency was used to differentiate deviants interspersed randomly among a standard tone. Mismatch responses were observed at 60-100 ms after stimulus onset for frequency increases of 5% and 12.5% but not for similarly descending deviants. The response diminished when the silent inter-stimulus interval was increased from 375 ms to 600 ms for +5% deviants and from 600 ms to 1000 ms for +12.5% deviants. In comparison to the oddball condition the response also diminished in a control condition in which no repetitive standards were presented (equiprobable condition). These findings suggest that the rat mismatch response is similar to the human MMN and indicate that anesthetized rats provide a valuable model for studies of central auditory processing.
format	article
author	Piia Astikainen Gabor Stefanics Miriam Nokia Arto Lipponen Fengyu Cong Markku Penttonen Timo Ruusuvirta
author_facet	Piia Astikainen Gabor Stefanics Miriam Nokia Arto Lipponen Fengyu Cong Markku Penttonen Timo Ruusuvirta
author_sort	Piia Astikainen
title	Memory-based mismatch response to frequency changes in rats.
title_short	Memory-based mismatch response to frequency changes in rats.
title_full	Memory-based mismatch response to frequency changes in rats.
title_fullStr	Memory-based mismatch response to frequency changes in rats.
title_full_unstemmed	Memory-based mismatch response to frequency changes in rats.
title_sort	memory-based mismatch response to frequency changes in rats.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/34e1cc5cda654e7e960b43b1ad63948d
work_keys_str_mv	AT piiaastikainen memorybasedmismatchresponsetofrequencychangesinrats AT gaborstefanics memorybasedmismatchresponsetofrequencychangesinrats AT miriamnokia memorybasedmismatchresponsetofrequencychangesinrats AT artolipponen memorybasedmismatchresponsetofrequencychangesinrats AT fengyucong memorybasedmismatchresponsetofrequencychangesinrats AT markkupenttonen memorybasedmismatchresponsetofrequencychangesinrats AT timoruusuvirta memorybasedmismatchresponsetofrequencychangesinrats
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Memory-based mismatch response to frequency changes in rats.

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