Inhibition of protein N-myristoylation blocks Plasmodium falciparum intraerythrocytic development, egress and invasion.

Inhibition of protein N-myristoylation blocks Plasmodium falciparum intraerythrocytic development, egress and invasion.

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We have combined chemical biology and genetic modification approaches to investigate the importance of protein myristoylation in the human malaria parasite, Plasmodium falciparum. Parasite treatment during schizogony in the last 10 to 15 hours of the erythrocytic cycle with IMP-1002, an inhibitor of...

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Detalles Bibliográficos
Autores principales: Anja C Schlott, Ellen Knuepfer, Judith L Green, Philip Hobson, Aaron J Borg, Julia Morales-Sanfrutos, Abigail J Perrin, Catherine Maclachlan, Lucy M Collinson, Ambrosius P Snijders, Edward W Tate, Anthony A Holder
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/34e864e4f85047e9879d4fa62f5010e1
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