Normal tissue architecture determines the evolutionary course of cancer

Some cancers occur in spatially constrained tissues such as the mammary gland, and how the morphological features influence the evolution of the cancer is unclear. Here, the authors use mathematical modeling to study the question of competition for space and provide inferences on the mode of evoluti...

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Autores principales:	Jeffrey West, Ryan O. Schenck, Chandler Gatenbee, Mark Robertson-Tessi, Alexander R. A. Anderson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/34e86c8a277e4ad28a7be94d4546747f
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spelling	oai:doaj.org-article:34e86c8a277e4ad28a7be94d4546747f2021-12-02T14:17:29ZNormal tissue architecture determines the evolutionary course of cancer10.1038/s41467-021-22123-12041-1723https://doaj.org/article/34e86c8a277e4ad28a7be94d4546747f2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22123-1https://doaj.org/toc/2041-1723Some cancers occur in spatially constrained tissues such as the mammary gland, and how the morphological features influence the evolution of the cancer is unclear. Here, the authors use mathematical modeling to study the question of competition for space and provide inferences on the mode of evolution of cancers in such tissues.Jeffrey WestRyan O. SchenckChandler GatenbeeMark Robertson-TessiAlexander R. A. AndersonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jeffrey West Ryan O. Schenck Chandler Gatenbee Mark Robertson-Tessi Alexander R. A. Anderson Normal tissue architecture determines the evolutionary course of cancer
description	Some cancers occur in spatially constrained tissues such as the mammary gland, and how the morphological features influence the evolution of the cancer is unclear. Here, the authors use mathematical modeling to study the question of competition for space and provide inferences on the mode of evolution of cancers in such tissues.
format	article
author	Jeffrey West Ryan O. Schenck Chandler Gatenbee Mark Robertson-Tessi Alexander R. A. Anderson
author_facet	Jeffrey West Ryan O. Schenck Chandler Gatenbee Mark Robertson-Tessi Alexander R. A. Anderson
author_sort	Jeffrey West
title	Normal tissue architecture determines the evolutionary course of cancer
title_short	Normal tissue architecture determines the evolutionary course of cancer
title_full	Normal tissue architecture determines the evolutionary course of cancer
title_fullStr	Normal tissue architecture determines the evolutionary course of cancer
title_full_unstemmed	Normal tissue architecture determines the evolutionary course of cancer
title_sort	normal tissue architecture determines the evolutionary course of cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/34e86c8a277e4ad28a7be94d4546747f
work_keys_str_mv	AT jeffreywest normaltissuearchitecturedeterminestheevolutionarycourseofcancer AT ryanoschenck normaltissuearchitecturedeterminestheevolutionarycourseofcancer AT chandlergatenbee normaltissuearchitecturedeterminestheevolutionarycourseofcancer AT markrobertsontessi normaltissuearchitecturedeterminestheevolutionarycourseofcancer AT alexanderraanderson normaltissuearchitecturedeterminestheevolutionarycourseofcancer
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Normal tissue architecture determines the evolutionary course of cancer

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