Transcranial electrical stimulation accelerates human sleep homeostasis.

The sleeping brain exhibits characteristic slow-wave activity which decays over the course of the night. This decay is thought to result from homeostatic synaptic downscaling. Transcranial electrical stimulation can entrain slow-wave oscillations (SWO) in the human electro-encephalogram (EEG). A com...

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Autores principales:	Davide Reato, Fernando Gasca, Abhishek Datta, Marom Bikson, Lisa Marshall, Lucas C Parra
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/34ea132cd2854702a26245bf173eca2c
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spelling	oai:doaj.org-article:34ea132cd2854702a26245bf173eca2c2021-11-18T05:52:27ZTranscranial electrical stimulation accelerates human sleep homeostasis.1553-734X1553-735810.1371/journal.pcbi.1002898https://doaj.org/article/34ea132cd2854702a26245bf173eca2c2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23459152/pdf/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358The sleeping brain exhibits characteristic slow-wave activity which decays over the course of the night. This decay is thought to result from homeostatic synaptic downscaling. Transcranial electrical stimulation can entrain slow-wave oscillations (SWO) in the human electro-encephalogram (EEG). A computational model of the underlying mechanism predicts that firing rates are predominantly increased during stimulation. Assuming that synaptic homeostasis is driven by average firing rates, we expected an acceleration of synaptic downscaling during stimulation, which is compensated by a reduced drive after stimulation. We show that 25 minutes of transcranial electrical stimulation, as predicted, reduced the decay of SWO in the remainder of the night. Anatomically accurate simulations of the field intensities on human cortex precisely matched the effect size in different EEG electrodes. Together these results suggest a mechanistic link between electrical stimulation and accelerated synaptic homeostasis in human sleep.Davide ReatoFernando GascaAbhishek DattaMarom BiksonLisa MarshallLucas C ParraPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 9, Iss 2, p e1002898 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Davide Reato Fernando Gasca Abhishek Datta Marom Bikson Lisa Marshall Lucas C Parra Transcranial electrical stimulation accelerates human sleep homeostasis.
description	The sleeping brain exhibits characteristic slow-wave activity which decays over the course of the night. This decay is thought to result from homeostatic synaptic downscaling. Transcranial electrical stimulation can entrain slow-wave oscillations (SWO) in the human electro-encephalogram (EEG). A computational model of the underlying mechanism predicts that firing rates are predominantly increased during stimulation. Assuming that synaptic homeostasis is driven by average firing rates, we expected an acceleration of synaptic downscaling during stimulation, which is compensated by a reduced drive after stimulation. We show that 25 minutes of transcranial electrical stimulation, as predicted, reduced the decay of SWO in the remainder of the night. Anatomically accurate simulations of the field intensities on human cortex precisely matched the effect size in different EEG electrodes. Together these results suggest a mechanistic link between electrical stimulation and accelerated synaptic homeostasis in human sleep.
format	article
author	Davide Reato Fernando Gasca Abhishek Datta Marom Bikson Lisa Marshall Lucas C Parra
author_facet	Davide Reato Fernando Gasca Abhishek Datta Marom Bikson Lisa Marshall Lucas C Parra
author_sort	Davide Reato
title	Transcranial electrical stimulation accelerates human sleep homeostasis.
title_short	Transcranial electrical stimulation accelerates human sleep homeostasis.
title_full	Transcranial electrical stimulation accelerates human sleep homeostasis.
title_fullStr	Transcranial electrical stimulation accelerates human sleep homeostasis.
title_full_unstemmed	Transcranial electrical stimulation accelerates human sleep homeostasis.
title_sort	transcranial electrical stimulation accelerates human sleep homeostasis.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/34ea132cd2854702a26245bf173eca2c
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Transcranial electrical stimulation accelerates human sleep homeostasis.

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