High Rate of Cytomegalovirus Detection in Cholestatic Preterm Infants

Objectives: To evaluate the prevalence of cytomegalovirus (CMV) infection in preterm infants with cholestasis.Study design: Preterm infants (<37 weeks gestational age) with cholestasis were tested for CMV DNA using Taqman PCR in blood cells from sedimented whole blood, plasma, and urine. Infa...

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Autores principales:	Jonas Teng, Anne Elwin, Soley Omarsdottir, Giulia Aquilano, Mireille Vanpee, Antal Nemeth, Afsar Rahbar, Kajsa Bohlin, Björn Fischler, Cecilia Söderberg-Nauclér
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cytomegalovirus liver diseases cholestasis preterm infants neonatal intensive care (unit) neonatal hyperbilirubinemia Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/34eac5581e3f45fda7ba1602f8bef08e
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spelling	oai:doaj.org-article:34eac5581e3f45fda7ba1602f8bef08e2021-11-30T18:29:22ZHigh Rate of Cytomegalovirus Detection in Cholestatic Preterm Infants2296-236010.3389/fped.2021.754941https://doaj.org/article/34eac5581e3f45fda7ba1602f8bef08e2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fped.2021.754941/fullhttps://doaj.org/toc/2296-2360Objectives: To evaluate the prevalence of cytomegalovirus (CMV) infection in preterm infants with cholestasis.Study design: Preterm infants (<37 weeks gestational age) with cholestasis were tested for CMV DNA using Taqman PCR in blood cells from sedimented whole blood, plasma, and urine. Infants were regarded as positive for CMV if any sample was tested positive. Their mothers were tested for CMV serostatus simultaneously. A control group of non-cholestatic preterm infants, and their mothers, were tested at a similar age.Results: A total of 69 preterm infants with a median gestational age of 26 weeks and 5 days were included, 45 cholestatic and 24 non-cholestatic. Of the cholestatic infants, 31/45 (69%) were CMV positive vs. 3/24 (13%) of the non-cholestatic infants (p < 0.001). Cholestatic infants were equally preterm as the non-cholestatic ones, but were more severely ill. After adjusting for the risk factors necrotizing enterocolitis, prolonged parenteral nutrition, and gestational age, being CMV positive remained significantly associated with cholestasis in a multivariable logistic regression model. Characteristics of CMV-positive and -negative cholestatic infants showed differences only for necrotizing enterocolitis, occurring in 55% (17/31) of CMV positive vs. 21% (3/14) of CMV negative (p = 0.054), and mortality. Eight cholestatic CMV-positive infants died (26%) vs. none of the CMV-negative infants (p = 0.044).Conclusions: CMV DNA was detected in two out of three cholestatic preterm infants, by far more often than in the non-cholestatic control group. Cholestasis with simultaneous detection of CMV DNA may be associated with increased mortality.Jonas TengJonas TengAnne ElwinAnne ElwinSoley OmarsdottirGiulia AquilanoMireille VanpeeMireille VanpeeAntal NemethAfsar RahbarAfsar RahbarKajsa BohlinKajsa BohlinBjörn FischlerBjörn FischlerCecilia Söderberg-NauclérCecilia Söderberg-NauclérFrontiers Media S.A.articlecytomegalovirusliver diseasescholestasispreterm infantsneonatal intensive care (unit)neonatal hyperbilirubinemiaPediatricsRJ1-570ENFrontiers in Pediatrics, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cytomegalovirus liver diseases cholestasis preterm infants neonatal intensive care (unit) neonatal hyperbilirubinemia Pediatrics RJ1-570
spellingShingle	cytomegalovirus liver diseases cholestasis preterm infants neonatal intensive care (unit) neonatal hyperbilirubinemia Pediatrics RJ1-570 Jonas Teng Jonas Teng Anne Elwin Anne Elwin Soley Omarsdottir Giulia Aquilano Mireille Vanpee Mireille Vanpee Antal Nemeth Afsar Rahbar Afsar Rahbar Kajsa Bohlin Kajsa Bohlin Björn Fischler Björn Fischler Cecilia Söderberg-Nauclér Cecilia Söderberg-Nauclér High Rate of Cytomegalovirus Detection in Cholestatic Preterm Infants
description	Objectives: To evaluate the prevalence of cytomegalovirus (CMV) infection in preterm infants with cholestasis.Study design: Preterm infants (<37 weeks gestational age) with cholestasis were tested for CMV DNA using Taqman PCR in blood cells from sedimented whole blood, plasma, and urine. Infants were regarded as positive for CMV if any sample was tested positive. Their mothers were tested for CMV serostatus simultaneously. A control group of non-cholestatic preterm infants, and their mothers, were tested at a similar age.Results: A total of 69 preterm infants with a median gestational age of 26 weeks and 5 days were included, 45 cholestatic and 24 non-cholestatic. Of the cholestatic infants, 31/45 (69%) were CMV positive vs. 3/24 (13%) of the non-cholestatic infants (p < 0.001). Cholestatic infants were equally preterm as the non-cholestatic ones, but were more severely ill. After adjusting for the risk factors necrotizing enterocolitis, prolonged parenteral nutrition, and gestational age, being CMV positive remained significantly associated with cholestasis in a multivariable logistic regression model. Characteristics of CMV-positive and -negative cholestatic infants showed differences only for necrotizing enterocolitis, occurring in 55% (17/31) of CMV positive vs. 21% (3/14) of CMV negative (p = 0.054), and mortality. Eight cholestatic CMV-positive infants died (26%) vs. none of the CMV-negative infants (p = 0.044).Conclusions: CMV DNA was detected in two out of three cholestatic preterm infants, by far more often than in the non-cholestatic control group. Cholestasis with simultaneous detection of CMV DNA may be associated with increased mortality.
format	article
author	Jonas Teng Jonas Teng Anne Elwin Anne Elwin Soley Omarsdottir Giulia Aquilano Mireille Vanpee Mireille Vanpee Antal Nemeth Afsar Rahbar Afsar Rahbar Kajsa Bohlin Kajsa Bohlin Björn Fischler Björn Fischler Cecilia Söderberg-Nauclér Cecilia Söderberg-Nauclér
author_facet	Jonas Teng Jonas Teng Anne Elwin Anne Elwin Soley Omarsdottir Giulia Aquilano Mireille Vanpee Mireille Vanpee Antal Nemeth Afsar Rahbar Afsar Rahbar Kajsa Bohlin Kajsa Bohlin Björn Fischler Björn Fischler Cecilia Söderberg-Nauclér Cecilia Söderberg-Nauclér
author_sort	Jonas Teng
title	High Rate of Cytomegalovirus Detection in Cholestatic Preterm Infants
title_short	High Rate of Cytomegalovirus Detection in Cholestatic Preterm Infants
title_full	High Rate of Cytomegalovirus Detection in Cholestatic Preterm Infants
title_fullStr	High Rate of Cytomegalovirus Detection in Cholestatic Preterm Infants
title_full_unstemmed	High Rate of Cytomegalovirus Detection in Cholestatic Preterm Infants
title_sort	high rate of cytomegalovirus detection in cholestatic preterm infants
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/34eac5581e3f45fda7ba1602f8bef08e
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High Rate of Cytomegalovirus Detection in Cholestatic Preterm Infants

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