Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish

Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish

Quint et al. use zebrafish lines deficient in one of two orthologs of the Gap Junction Delta-2 (GJD2) gene, which is associated with myopia by genome-wide association studies. They link gjd2 with refractive error and report evidence to suggest that gjd2a plays a role in ocular biometry whilst gjd2b,...

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Autores principales: Wim H. Quint, Kirke C. D. Tadema, Erik de Vrieze, Rachel M. Lukowicz, Sanne Broekman, Beerend H. J. Winkelman, Melanie Hoevenaars, H. Martijn de Gruiter, Erwin van Wijk, Frank Schaeffel, Magda Meester-Smoor, Adam C. Miller, Rob Willemsen, Caroline C. W. Klaver, Adriana I. Iglesias
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/34eb9c818e744750bea9066079088f6f
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spelling oai:doaj.org-article:34eb9c818e744750bea9066079088f6f2021-12-02T18:24:52ZLoss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish10.1038/s42003-021-02185-z2399-3642https://doaj.org/article/34eb9c818e744750bea9066079088f6f2021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02185-zhttps://doaj.org/toc/2399-3642Quint et al. use zebrafish lines deficient in one of two orthologs of the Gap Junction Delta-2 (GJD2) gene, which is associated with myopia by genome-wide association studies. They link gjd2 with refractive error and report evidence to suggest that gjd2a plays a role in ocular biometry whilst gjd2b, previously found in the retina, possesses an additional lenticular role.Wim H. QuintKirke C. D. TademaErik de VriezeRachel M. LukowiczSanne BroekmanBeerend H. J. WinkelmanMelanie HoevenaarsH. Martijn de GruiterErwin van WijkFrank SchaeffelMagda Meester-SmoorAdam C. MillerRob WillemsenCaroline C. W. KlaverAdriana I. IglesiasNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Wim H. Quint
Kirke C. D. Tadema
Erik de Vrieze
Rachel M. Lukowicz
Sanne Broekman
Beerend H. J. Winkelman
Melanie Hoevenaars
H. Martijn de Gruiter
Erwin van Wijk
Frank Schaeffel
Magda Meester-Smoor
Adam C. Miller
Rob Willemsen
Caroline C. W. Klaver
Adriana I. Iglesias
Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish
description Quint et al. use zebrafish lines deficient in one of two orthologs of the Gap Junction Delta-2 (GJD2) gene, which is associated with myopia by genome-wide association studies. They link gjd2 with refractive error and report evidence to suggest that gjd2a plays a role in ocular biometry whilst gjd2b, previously found in the retina, possesses an additional lenticular role.
format article
author Wim H. Quint
Kirke C. D. Tadema
Erik de Vrieze
Rachel M. Lukowicz
Sanne Broekman
Beerend H. J. Winkelman
Melanie Hoevenaars
H. Martijn de Gruiter
Erwin van Wijk
Frank Schaeffel
Magda Meester-Smoor
Adam C. Miller
Rob Willemsen
Caroline C. W. Klaver
Adriana I. Iglesias
author_facet Wim H. Quint
Kirke C. D. Tadema
Erik de Vrieze
Rachel M. Lukowicz
Sanne Broekman
Beerend H. J. Winkelman
Melanie Hoevenaars
H. Martijn de Gruiter
Erwin van Wijk
Frank Schaeffel
Magda Meester-Smoor
Adam C. Miller
Rob Willemsen
Caroline C. W. Klaver
Adriana I. Iglesias
author_sort Wim H. Quint
title Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish
title_short Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish
title_full Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish
title_fullStr Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish
title_full_unstemmed Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish
title_sort loss of gap junction delta-2 (gjd2) gene orthologs leads to refractive error in zebrafish
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/34eb9c818e744750bea9066079088f6f
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