Pol α-primase dependent nuclear localization of the mammalian CST complex

Kelich, Papaioannou and Skordalakes investigate the intracellular localization dynamics of the mammalian CST, a protein complex critical for telomere maintenance and homeostasis. They find that the CST complex localizes to the nucleus in a cell cycle-dependent manner that requires binding by Pol α-p...

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Auteurs principaux:	Joseph M. Kelich, Harry Papaioannou, Emmanuel Skordalakes
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Biology (General) QH301-705.5
Accès en ligne:	https://doaj.org/article/34ee3c1cb27b4cec8f93e8693f09377f
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spelling	oai:doaj.org-article:34ee3c1cb27b4cec8f93e8693f09377f2021-12-02T11:39:38ZPol α-primase dependent nuclear localization of the mammalian CST complex10.1038/s42003-021-01845-42399-3642https://doaj.org/article/34ee3c1cb27b4cec8f93e8693f09377f2021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01845-4https://doaj.org/toc/2399-3642Kelich, Papaioannou and Skordalakes investigate the intracellular localization dynamics of the mammalian CST, a protein complex critical for telomere maintenance and homeostasis. They find that the CST complex localizes to the nucleus in a cell cycle-dependent manner that requires binding by Pol α-primase and that mutations affecting its nuclear import are associated with human telomere syndromes and cancer.Joseph M. KelichHarry PapaioannouEmmanuel SkordalakesNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Joseph M. Kelich Harry Papaioannou Emmanuel Skordalakes Pol α-primase dependent nuclear localization of the mammalian CST complex
description	Kelich, Papaioannou and Skordalakes investigate the intracellular localization dynamics of the mammalian CST, a protein complex critical for telomere maintenance and homeostasis. They find that the CST complex localizes to the nucleus in a cell cycle-dependent manner that requires binding by Pol α-primase and that mutations affecting its nuclear import are associated with human telomere syndromes and cancer.
format	article
author	Joseph M. Kelich Harry Papaioannou Emmanuel Skordalakes
author_facet	Joseph M. Kelich Harry Papaioannou Emmanuel Skordalakes
author_sort	Joseph M. Kelich
title	Pol α-primase dependent nuclear localization of the mammalian CST complex
title_short	Pol α-primase dependent nuclear localization of the mammalian CST complex
title_full	Pol α-primase dependent nuclear localization of the mammalian CST complex
title_fullStr	Pol α-primase dependent nuclear localization of the mammalian CST complex
title_full_unstemmed	Pol α-primase dependent nuclear localization of the mammalian CST complex
title_sort	pol α-primase dependent nuclear localization of the mammalian cst complex
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/34ee3c1cb27b4cec8f93e8693f09377f
work_keys_str_mv	AT josephmkelich polaprimasedependentnuclearlocalizationofthemammaliancstcomplex AT harrypapaioannou polaprimasedependentnuclearlocalizationofthemammaliancstcomplex AT emmanuelskordalakes polaprimasedependentnuclearlocalizationofthemammaliancstcomplex
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Pol α-primase dependent nuclear localization of the mammalian CST complex

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