Combining EEG and MEG for the reconstruction of epileptic activity using a calibrated realistic volume conductor model.

To increase the reliability for the non-invasive determination of the irritative zone in presurgical epilepsy diagnosis, we introduce here a new experimental and methodological source analysis pipeline that combines the complementary information in EEG and MEG, and apply it to data from a patient, s...

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Autores principales:	Ümit Aydin, Johannes Vorwerk, Philipp Küpper, Marcel Heers, Harald Kugel, Andreas Galka, Laith Hamid, Jörg Wellmer, Christoph Kellinghaus, Stefan Rampp, Carsten Hermann Wolters
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/34ee7cc7195046d482f577555fc18f05
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spelling	oai:doaj.org-article:34ee7cc7195046d482f577555fc18f052021-11-18T08:25:58ZCombining EEG and MEG for the reconstruction of epileptic activity using a calibrated realistic volume conductor model.1932-620310.1371/journal.pone.0093154https://doaj.org/article/34ee7cc7195046d482f577555fc18f052014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24671208/?tool=EBIhttps://doaj.org/toc/1932-6203To increase the reliability for the non-invasive determination of the irritative zone in presurgical epilepsy diagnosis, we introduce here a new experimental and methodological source analysis pipeline that combines the complementary information in EEG and MEG, and apply it to data from a patient, suffering from refractory focal epilepsy. Skull conductivity parameters in a six compartment finite element head model with brain anisotropy, constructed from individual MRI data, are estimated in a calibration procedure using somatosensory evoked potential (SEP) and field (SEF) data. These data are measured in a single run before acquisition of further runs of spontaneous epileptic activity. Our results show that even for single interictal spikes, volume conduction effects dominate over noise and need to be taken into account for accurate source analysis. While cerebrospinal fluid and brain anisotropy influence both modalities, only EEG is sensitive to skull conductivity and conductivity calibration significantly reduces the difference in especially depth localization of both modalities, emphasizing its importance for combining EEG and MEG source analysis. On the other hand, localization differences which are due to the distinct sensitivity profiles of EEG and MEG persist. In case of a moderate error in skull conductivity, combined source analysis results can still profit from the different sensitivity profiles of EEG and MEG to accurately determine location, orientation and strength of the underlying sources. On the other side, significant errors in skull modeling are reflected in EEG reconstruction errors and could reduce the goodness of fit to combined datasets. For combined EEG and MEG source analysis, we therefore recommend calibrating skull conductivity using additionally acquired SEP/SEF data.Ümit AydinJohannes VorwerkPhilipp KüpperMarcel HeersHarald KugelAndreas GalkaLaith HamidJörg WellmerChristoph KellinghausStefan RamppCarsten Hermann WoltersPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 3, p e93154 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ümit Aydin Johannes Vorwerk Philipp Küpper Marcel Heers Harald Kugel Andreas Galka Laith Hamid Jörg Wellmer Christoph Kellinghaus Stefan Rampp Carsten Hermann Wolters Combining EEG and MEG for the reconstruction of epileptic activity using a calibrated realistic volume conductor model.
description	To increase the reliability for the non-invasive determination of the irritative zone in presurgical epilepsy diagnosis, we introduce here a new experimental and methodological source analysis pipeline that combines the complementary information in EEG and MEG, and apply it to data from a patient, suffering from refractory focal epilepsy. Skull conductivity parameters in a six compartment finite element head model with brain anisotropy, constructed from individual MRI data, are estimated in a calibration procedure using somatosensory evoked potential (SEP) and field (SEF) data. These data are measured in a single run before acquisition of further runs of spontaneous epileptic activity. Our results show that even for single interictal spikes, volume conduction effects dominate over noise and need to be taken into account for accurate source analysis. While cerebrospinal fluid and brain anisotropy influence both modalities, only EEG is sensitive to skull conductivity and conductivity calibration significantly reduces the difference in especially depth localization of both modalities, emphasizing its importance for combining EEG and MEG source analysis. On the other hand, localization differences which are due to the distinct sensitivity profiles of EEG and MEG persist. In case of a moderate error in skull conductivity, combined source analysis results can still profit from the different sensitivity profiles of EEG and MEG to accurately determine location, orientation and strength of the underlying sources. On the other side, significant errors in skull modeling are reflected in EEG reconstruction errors and could reduce the goodness of fit to combined datasets. For combined EEG and MEG source analysis, we therefore recommend calibrating skull conductivity using additionally acquired SEP/SEF data.
format	article
author	Ümit Aydin Johannes Vorwerk Philipp Küpper Marcel Heers Harald Kugel Andreas Galka Laith Hamid Jörg Wellmer Christoph Kellinghaus Stefan Rampp Carsten Hermann Wolters
author_facet	Ümit Aydin Johannes Vorwerk Philipp Küpper Marcel Heers Harald Kugel Andreas Galka Laith Hamid Jörg Wellmer Christoph Kellinghaus Stefan Rampp Carsten Hermann Wolters
author_sort	Ümit Aydin
title	Combining EEG and MEG for the reconstruction of epileptic activity using a calibrated realistic volume conductor model.
title_short	Combining EEG and MEG for the reconstruction of epileptic activity using a calibrated realistic volume conductor model.
title_full	Combining EEG and MEG for the reconstruction of epileptic activity using a calibrated realistic volume conductor model.
title_fullStr	Combining EEG and MEG for the reconstruction of epileptic activity using a calibrated realistic volume conductor model.
title_full_unstemmed	Combining EEG and MEG for the reconstruction of epileptic activity using a calibrated realistic volume conductor model.
title_sort	combining eeg and meg for the reconstruction of epileptic activity using a calibrated realistic volume conductor model.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/34ee7cc7195046d482f577555fc18f05
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Combining EEG and MEG for the reconstruction of epileptic activity using a calibrated realistic volume conductor model.

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