Temporal dynamics of TMS interference over preparatory alpha activity during semantic decisions

Abstract The mean amplitude of the EEG alpha (8–12 Hz) power de-synchronization (ERD) is a robust electrophysiological correlate of task anticipation. Furthermore, in paradigms using a fixed period between warning and target stimuli, such alpha de-synchronization tends to increase and to peak just b...

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Autores principales:	Sara Spadone, Carlo Sestieri, Antonello Baldassarre, Paolo Capotosto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/34f23fc00d544cf39f6cfd2f6651dfea
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spelling	oai:doaj.org-article:34f23fc00d544cf39f6cfd2f6651dfea2021-12-02T16:08:00ZTemporal dynamics of TMS interference over preparatory alpha activity during semantic decisions10.1038/s41598-017-02616-02045-2322https://doaj.org/article/34f23fc00d544cf39f6cfd2f6651dfea2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02616-0https://doaj.org/toc/2045-2322Abstract The mean amplitude of the EEG alpha (8–12 Hz) power de-synchronization (ERD) is a robust electrophysiological correlate of task anticipation. Furthermore, in paradigms using a fixed period between warning and target stimuli, such alpha de-synchronization tends to increase and to peak just before target presentation. Previous studies from our group showed that the anticipatory alpha ERD can be modulated when magnetic stimulation is delivered over specific cortical regions during a variety of cognitive tasks. In this study we investigate the temporal dynamics of the anticipatory alpha ERD and test whether the magnetic stimulation produces either a general attenuation or an interruption of the typical development of alpha ERD. We report that, during a semantic decision task, rTMS over left AG, a region previously associated to semantic memory retrieval, shortened the peak latency and decreased the peak amplitude of the anticipatory alpha de-synchronization as compared to both active (left IPS) and non-active (Sham) TMS conditions. These results, while supporting the causal role of the left AG in the anticipation of a semantic decision task, suggest that magnetic interference not simply reduces the mean amplitude of anticipatory alpha ERD but also interrupts its typical temporal evolution in paradigms employing fixed cue-target intervals.Sara SpadoneCarlo SestieriAntonello BaldassarrePaolo CapotostoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sara Spadone Carlo Sestieri Antonello Baldassarre Paolo Capotosto Temporal dynamics of TMS interference over preparatory alpha activity during semantic decisions
description	Abstract The mean amplitude of the EEG alpha (8–12 Hz) power de-synchronization (ERD) is a robust electrophysiological correlate of task anticipation. Furthermore, in paradigms using a fixed period between warning and target stimuli, such alpha de-synchronization tends to increase and to peak just before target presentation. Previous studies from our group showed that the anticipatory alpha ERD can be modulated when magnetic stimulation is delivered over specific cortical regions during a variety of cognitive tasks. In this study we investigate the temporal dynamics of the anticipatory alpha ERD and test whether the magnetic stimulation produces either a general attenuation or an interruption of the typical development of alpha ERD. We report that, during a semantic decision task, rTMS over left AG, a region previously associated to semantic memory retrieval, shortened the peak latency and decreased the peak amplitude of the anticipatory alpha de-synchronization as compared to both active (left IPS) and non-active (Sham) TMS conditions. These results, while supporting the causal role of the left AG in the anticipation of a semantic decision task, suggest that magnetic interference not simply reduces the mean amplitude of anticipatory alpha ERD but also interrupts its typical temporal evolution in paradigms employing fixed cue-target intervals.
format	article
author	Sara Spadone Carlo Sestieri Antonello Baldassarre Paolo Capotosto
author_facet	Sara Spadone Carlo Sestieri Antonello Baldassarre Paolo Capotosto
author_sort	Sara Spadone
title	Temporal dynamics of TMS interference over preparatory alpha activity during semantic decisions
title_short	Temporal dynamics of TMS interference over preparatory alpha activity during semantic decisions
title_full	Temporal dynamics of TMS interference over preparatory alpha activity during semantic decisions
title_fullStr	Temporal dynamics of TMS interference over preparatory alpha activity during semantic decisions
title_full_unstemmed	Temporal dynamics of TMS interference over preparatory alpha activity during semantic decisions
title_sort	temporal dynamics of tms interference over preparatory alpha activity during semantic decisions
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/34f23fc00d544cf39f6cfd2f6651dfea
work_keys_str_mv	AT saraspadone temporaldynamicsoftmsinterferenceoverpreparatoryalphaactivityduringsemanticdecisions AT carlosestieri temporaldynamicsoftmsinterferenceoverpreparatoryalphaactivityduringsemanticdecisions AT antonellobaldassarre temporaldynamicsoftmsinterferenceoverpreparatoryalphaactivityduringsemanticdecisions AT paolocapotosto temporaldynamicsoftmsinterferenceoverpreparatoryalphaactivityduringsemanticdecisions
_version_	1718384646835666944

Temporal dynamics of TMS interference over preparatory alpha activity during semantic decisions

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