Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier
Débora B Vieira,1 Lionel F Gamarra1,2 1Hospital Israelita Albert Einstein, São Paulo, Brazil; 2Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, Brazil Abstract: This review summarizes articles that have been repor...
Guardado en:
| Autores principales: | , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2016
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/34f43ec667da44b786ed0829b34a92af |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:34f43ec667da44b786ed0829b34a92af |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:34f43ec667da44b786ed0829b34a92af2021-12-02T05:36:20ZGetting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier1178-2013https://doaj.org/article/34f43ec667da44b786ed0829b34a92af2016-10-01T00:00:00Zhttps://www.dovepress.com/getting-into-the-brain-liposome-based-strategies-for-effective-drug-de-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Débora B Vieira,1 Lionel F Gamarra1,2 1Hospital Israelita Albert Einstein, São Paulo, Brazil; 2Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, Brazil Abstract: This review summarizes articles that have been reported in literature on liposome-based strategies for effective drug delivery across the blood–brain barrier. Due to their unique physicochemical characteristics, liposomes have been widely investigated for their application in drug delivery and in vivo bioimaging for the treatment and/or diagnosis of neurological diseases, such as Alzheimer’s, Parkinson’s, stroke, and glioma. Several strategies have been used to deliver drug and/or imaging agents to the brain. Covalent ligation of such macromolecules as peptides, antibodies, and RNA aptamers is an effective method for receptor-targeting liposomes, which allows their blood–brain barrier penetration and/or the delivery of their therapeutic molecule specifically to the disease site. Additionally, methods have been employed for the development of liposomes that can respond to external stimuli. It can be concluded that the development of liposomes for brain delivery is still in its infancy, although these systems have the potential to revolutionize the ways in which medicine is administered. Keywords: Alzheimer, Parkinson, stroke, cerebral ischemia, glioma, liposomes, blood–brain barrierVieira DBGamarra LFDove Medical PressarticleAlzheimerParkinsonstrokecerebral ischemiagliomaliposomesblood-brain barrierMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 11, Pp 5381-5414 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Alzheimer Parkinson stroke cerebral ischemia glioma liposomes blood-brain barrier Medicine (General) R5-920 |
| spellingShingle |
Alzheimer Parkinson stroke cerebral ischemia glioma liposomes blood-brain barrier Medicine (General) R5-920 Vieira DB Gamarra LF Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier |
| description |
Débora B Vieira,1 Lionel F Gamarra1,2 1Hospital Israelita Albert Einstein, São Paulo, Brazil; 2Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, Brazil Abstract: This review summarizes articles that have been reported in literature on liposome-based strategies for effective drug delivery across the blood–brain barrier. Due to their unique physicochemical characteristics, liposomes have been widely investigated for their application in drug delivery and in vivo bioimaging for the treatment and/or diagnosis of neurological diseases, such as Alzheimer’s, Parkinson’s, stroke, and glioma. Several strategies have been used to deliver drug and/or imaging agents to the brain. Covalent ligation of such macromolecules as peptides, antibodies, and RNA aptamers is an effective method for receptor-targeting liposomes, which allows their blood–brain barrier penetration and/or the delivery of their therapeutic molecule specifically to the disease site. Additionally, methods have been employed for the development of liposomes that can respond to external stimuli. It can be concluded that the development of liposomes for brain delivery is still in its infancy, although these systems have the potential to revolutionize the ways in which medicine is administered. Keywords: Alzheimer, Parkinson, stroke, cerebral ischemia, glioma, liposomes, blood–brain barrier |
| format |
article |
| author |
Vieira DB Gamarra LF |
| author_facet |
Vieira DB Gamarra LF |
| author_sort |
Vieira DB |
| title |
Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier |
| title_short |
Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier |
| title_full |
Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier |
| title_fullStr |
Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier |
| title_full_unstemmed |
Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier |
| title_sort |
getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier |
| publisher |
Dove Medical Press |
| publishDate |
2016 |
| url |
https://doaj.org/article/34f43ec667da44b786ed0829b34a92af |
| work_keys_str_mv |
AT vieiradb gettingintothebrainliposomebasedstrategiesforeffectivedrugdeliveryacrossthebloodndashbrainbarrier AT gamarralf gettingintothebrainliposomebasedstrategiesforeffectivedrugdeliveryacrossthebloodndashbrainbarrier |
| _version_ |
1718400287971999744 |