AURKB as a target in non-small cell lung cancer with acquired resistance to anti-EGFR therapy

Non-small cell lung cancer with EGFR mutations are known to develop resistance to EGFR tyrosine kinase inhibitors. Here, the authors show AURKB activation to be associated with resistance in EGFR mutant lung cancer cells, and that AURKB is a therapeutic target in resistant tumours that lack the p.T7...

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Autores principales:	Jordi Bertran-Alamillo, Valérie Cattan, Marie Schoumacher, Jordi Codony-Servat, Ana Giménez-Capitán, Frédérique Cantero, Mike Burbridge, Sonia Rodríguez, Cristina Teixidó, Ruth Roman, Josep Castellví, Silvia García-Román, Carles Codony-Servat, Santiago Viteri, Andrés-Felipe Cardona, Niki Karachaliou, Rafael Rosell, Miguel-Angel Molina-Vila
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/34f8c0286b2b4c818818bdd02b7b3019
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:34f8c0286b2b4c818818bdd02b7b30192021-12-02T16:57:23ZAURKB as a target in non-small cell lung cancer with acquired resistance to anti-EGFR therapy10.1038/s41467-019-09734-52041-1723https://doaj.org/article/34f8c0286b2b4c818818bdd02b7b30192019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09734-5https://doaj.org/toc/2041-1723Non-small cell lung cancer with EGFR mutations are known to develop resistance to EGFR tyrosine kinase inhibitors. Here, the authors show AURKB activation to be associated with resistance in EGFR mutant lung cancer cells, and that AURKB is a therapeutic target in resistant tumours that lack the p.T790M or other acquired mutations.Jordi Bertran-AlamilloValérie CattanMarie SchoumacherJordi Codony-ServatAna Giménez-CapitánFrédérique CanteroMike BurbridgeSonia RodríguezCristina TeixidóRuth RomanJosep CastellvíSilvia García-RománCarles Codony-ServatSantiago ViteriAndrés-Felipe CardonaNiki KarachaliouRafael RosellMiguel-Angel Molina-VilaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jordi Bertran-Alamillo Valérie Cattan Marie Schoumacher Jordi Codony-Servat Ana Giménez-Capitán Frédérique Cantero Mike Burbridge Sonia Rodríguez Cristina Teixidó Ruth Roman Josep Castellví Silvia García-Román Carles Codony-Servat Santiago Viteri Andrés-Felipe Cardona Niki Karachaliou Rafael Rosell Miguel-Angel Molina-Vila AURKB as a target in non-small cell lung cancer with acquired resistance to anti-EGFR therapy
description	Non-small cell lung cancer with EGFR mutations are known to develop resistance to EGFR tyrosine kinase inhibitors. Here, the authors show AURKB activation to be associated with resistance in EGFR mutant lung cancer cells, and that AURKB is a therapeutic target in resistant tumours that lack the p.T790M or other acquired mutations.
format	article
author	Jordi Bertran-Alamillo Valérie Cattan Marie Schoumacher Jordi Codony-Servat Ana Giménez-Capitán Frédérique Cantero Mike Burbridge Sonia Rodríguez Cristina Teixidó Ruth Roman Josep Castellví Silvia García-Román Carles Codony-Servat Santiago Viteri Andrés-Felipe Cardona Niki Karachaliou Rafael Rosell Miguel-Angel Molina-Vila
author_facet	Jordi Bertran-Alamillo Valérie Cattan Marie Schoumacher Jordi Codony-Servat Ana Giménez-Capitán Frédérique Cantero Mike Burbridge Sonia Rodríguez Cristina Teixidó Ruth Roman Josep Castellví Silvia García-Román Carles Codony-Servat Santiago Viteri Andrés-Felipe Cardona Niki Karachaliou Rafael Rosell Miguel-Angel Molina-Vila
author_sort	Jordi Bertran-Alamillo
title	AURKB as a target in non-small cell lung cancer with acquired resistance to anti-EGFR therapy
title_short	AURKB as a target in non-small cell lung cancer with acquired resistance to anti-EGFR therapy
title_full	AURKB as a target in non-small cell lung cancer with acquired resistance to anti-EGFR therapy
title_fullStr	AURKB as a target in non-small cell lung cancer with acquired resistance to anti-EGFR therapy
title_full_unstemmed	AURKB as a target in non-small cell lung cancer with acquired resistance to anti-EGFR therapy
title_sort	aurkb as a target in non-small cell lung cancer with acquired resistance to anti-egfr therapy
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/34f8c0286b2b4c818818bdd02b7b3019
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AURKB as a target in non-small cell lung cancer with acquired resistance to anti-EGFR therapy

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