Protein polarization driven by nucleoid exclusion of DnaK(HSP70)–substrate complexes

Many bacterial proteins exhibit spatially defined localization important for function. Here the authors show that the polar localization of Shigella IpaC type III secretion substrate is mediated by its interaction with the DnaK chaperone and occlusion by the bacterial nucleoid.

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Autores principales: Clémence Collet, Jenny-Lee Thomassin, Olivera Francetic, Pierre Genevaux, Guy Tran Van Nhieu
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Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/34f8c4d1222449c3af8aeff533690b22
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spelling oai:doaj.org-article:34f8c4d1222449c3af8aeff533690b222021-12-02T16:49:48ZProtein polarization driven by nucleoid exclusion of DnaK(HSP70)–substrate complexes10.1038/s41467-018-04414-22041-1723https://doaj.org/article/34f8c4d1222449c3af8aeff533690b222018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04414-2https://doaj.org/toc/2041-1723Many bacterial proteins exhibit spatially defined localization important for function. Here the authors show that the polar localization of Shigella IpaC type III secretion substrate is mediated by its interaction with the DnaK chaperone and occlusion by the bacterial nucleoid.Clémence ColletJenny-Lee ThomassinOlivera FranceticPierre GenevauxGuy Tran Van NhieuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Clémence Collet
Jenny-Lee Thomassin
Olivera Francetic
Pierre Genevaux
Guy Tran Van Nhieu
Protein polarization driven by nucleoid exclusion of DnaK(HSP70)–substrate complexes
description Many bacterial proteins exhibit spatially defined localization important for function. Here the authors show that the polar localization of Shigella IpaC type III secretion substrate is mediated by its interaction with the DnaK chaperone and occlusion by the bacterial nucleoid.
format article
author Clémence Collet
Jenny-Lee Thomassin
Olivera Francetic
Pierre Genevaux
Guy Tran Van Nhieu
author_facet Clémence Collet
Jenny-Lee Thomassin
Olivera Francetic
Pierre Genevaux
Guy Tran Van Nhieu
author_sort Clémence Collet
title Protein polarization driven by nucleoid exclusion of DnaK(HSP70)–substrate complexes
title_short Protein polarization driven by nucleoid exclusion of DnaK(HSP70)–substrate complexes
title_full Protein polarization driven by nucleoid exclusion of DnaK(HSP70)–substrate complexes
title_fullStr Protein polarization driven by nucleoid exclusion of DnaK(HSP70)–substrate complexes
title_full_unstemmed Protein polarization driven by nucleoid exclusion of DnaK(HSP70)–substrate complexes
title_sort protein polarization driven by nucleoid exclusion of dnak(hsp70)–substrate complexes
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/34f8c4d1222449c3af8aeff533690b22
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