Botulinum toxin relieves anxiety and depression in patients with hemifacial spasm and blepharospasm

Hongjuan Dong, Shanghua Fan, Ying Luo, Bin Peng Department of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, China Objective: To explore the efficacy of botulinum toxin type A (BTX-A) therapy in relieving anxiety and depression in patients with hemifacial spasm (HFS) and benign esse...

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Autores principales:	Dong H, Fan S, Luo Y, Peng B
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Hemifacial spasm Blepharospasm Anxiety Depression Botulinum toxin type A Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/34f9adf5d1594de0ba499b95466ac112
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spelling	oai:doaj.org-article:34f9adf5d1594de0ba499b95466ac1122021-12-02T06:27:56ZBotulinum toxin relieves anxiety and depression in patients with hemifacial spasm and blepharospasm1178-2021https://doaj.org/article/34f9adf5d1594de0ba499b95466ac1122018-12-01T00:00:00Zhttps://www.dovepress.com/botulinum-toxin-relieves-anxiety-and-depression-in-patients-with-hemif-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Hongjuan Dong, Shanghua Fan, Ying Luo, Bin Peng Department of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, China Objective: To explore the efficacy of botulinum toxin type A (BTX-A) therapy in relieving anxiety and depression in patients with hemifacial spasm (HFS) and benign essential blepharospasm (BEB).Patients and method: Ninety idiopathic HFS patients and 90 BEB patients were enrolled. The anxiety and depression status were evaluated by self-rating anxiety scale (SAS) and self-rating depression scale (SDS), respectively, before and after the injection of BTX-A.Results: Before treatment, the SAS and SDS scores of HFS patients were 41.25±6.35 and 42.25±7.57, respectively. The SAS scores were 40.17±8.36 for males and 43.56±6.10 for females (P=0.031). The SDS scores were 40.25±6.46 for males and 45.48±7.31 for females (P=0.008). After treatment, the SAS and SDS scores were 30.12±4.35 and 30.58±4.89, respectively. There was a significant difference in the SAS and SDS scores before and after treatment. Before treatment, the SAS scores of male and female BEB patients were 56.45±8.75 and 60.89±9.11, respectively, and the SDS scores of male and female BEB patients were 57.90±7.93 and 60.12±8.35, respectively. After treatment, the SAS score was 38.17±3.67 and the SDS score was 38.12±4.15, with a significant difference in before and after treatment scores.Conclusion: In HFS and BEB, especially in female patients, there is an association with anxiety and depression. BTX-A can improve the symptoms of anxiety and depression. Keywords: hemifacial spasm, blepharospasm, anxiety, depression, botulinum toxin type A Dong HFan SLuo YPeng BDove Medical PressarticleHemifacial spasmBlepharospasmAnxietyDepressionBotulinum toxin type ANeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 33-36 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hemifacial spasm Blepharospasm Anxiety Depression Botulinum toxin type A Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Hemifacial spasm Blepharospasm Anxiety Depression Botulinum toxin type A Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Dong H Fan S Luo Y Peng B Botulinum toxin relieves anxiety and depression in patients with hemifacial spasm and blepharospasm
description	Hongjuan Dong, Shanghua Fan, Ying Luo, Bin Peng Department of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, China Objective: To explore the efficacy of botulinum toxin type A (BTX-A) therapy in relieving anxiety and depression in patients with hemifacial spasm (HFS) and benign essential blepharospasm (BEB).Patients and method: Ninety idiopathic HFS patients and 90 BEB patients were enrolled. The anxiety and depression status were evaluated by self-rating anxiety scale (SAS) and self-rating depression scale (SDS), respectively, before and after the injection of BTX-A.Results: Before treatment, the SAS and SDS scores of HFS patients were 41.25±6.35 and 42.25±7.57, respectively. The SAS scores were 40.17±8.36 for males and 43.56±6.10 for females (P=0.031). The SDS scores were 40.25±6.46 for males and 45.48±7.31 for females (P=0.008). After treatment, the SAS and SDS scores were 30.12±4.35 and 30.58±4.89, respectively. There was a significant difference in the SAS and SDS scores before and after treatment. Before treatment, the SAS scores of male and female BEB patients were 56.45±8.75 and 60.89±9.11, respectively, and the SDS scores of male and female BEB patients were 57.90±7.93 and 60.12±8.35, respectively. After treatment, the SAS score was 38.17±3.67 and the SDS score was 38.12±4.15, with a significant difference in before and after treatment scores.Conclusion: In HFS and BEB, especially in female patients, there is an association with anxiety and depression. BTX-A can improve the symptoms of anxiety and depression. Keywords: hemifacial spasm, blepharospasm, anxiety, depression, botulinum toxin type A
format	article
author	Dong H Fan S Luo Y Peng B
author_facet	Dong H Fan S Luo Y Peng B
author_sort	Dong H
title	Botulinum toxin relieves anxiety and depression in patients with hemifacial spasm and blepharospasm
title_short	Botulinum toxin relieves anxiety and depression in patients with hemifacial spasm and blepharospasm
title_full	Botulinum toxin relieves anxiety and depression in patients with hemifacial spasm and blepharospasm
title_fullStr	Botulinum toxin relieves anxiety and depression in patients with hemifacial spasm and blepharospasm
title_full_unstemmed	Botulinum toxin relieves anxiety and depression in patients with hemifacial spasm and blepharospasm
title_sort	botulinum toxin relieves anxiety and depression in patients with hemifacial spasm and blepharospasm
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/34f9adf5d1594de0ba499b95466ac112
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Botulinum toxin relieves anxiety and depression in patients with hemifacial spasm and blepharospasm

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