Identification of Reactive Hypoglycemia with Different Basic BMI and Its Causes by Prolonged Oral Glucose Tolerance Test

Xue Lv,1 Kun Fang,2 Wenqing Hao,1 Yuxin Han,1 Nailong Yang,1 Qing Yu1 1Department of Endocrinology and Metabolism, Affiliated Hospital of Qingdao University, Qingdao, Shandong, People’s Republic of China; 2Division of Health Management Center, Qingdao Municipal Hospital, Qingdao, Shandong,...

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Autores principales:	Lv X, Fang K, Hao W, Han Y, Yang N, Yu Q
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	reactive hypoglycemia prolonged oral glucose tolerance test insulin resistance low-carb ketogenic diet Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/34fa62557b054ecbab3073bdb952df72
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spelling	oai:doaj.org-article:34fa62557b054ecbab3073bdb952df722021-12-02T15:16:29ZIdentification of Reactive Hypoglycemia with Different Basic BMI and Its Causes by Prolonged Oral Glucose Tolerance Test1178-7007https://doaj.org/article/34fa62557b054ecbab3073bdb952df722020-12-01T00:00:00Zhttps://www.dovepress.com/identification-of-reactive-hypoglycemia-with-different-basic-bmi-and-i-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Xue Lv,1 Kun Fang,2 Wenqing Hao,1 Yuxin Han,1 Nailong Yang,1 Qing Yu1 1Department of Endocrinology and Metabolism, Affiliated Hospital of Qingdao University, Qingdao, Shandong, People’s Republic of China; 2Division of Health Management Center, Qingdao Municipal Hospital, Qingdao, Shandong, People’s Republic of ChinaCorrespondence: Nailong YangDepartment of Endocrinology and Metabolism, Affiliated Hospital of Qingdao University, Qingdao University of Medicine, No. 1677, Wutai Mountain Road, Huangdao District, Qingdao, Shandong 266555, People’s Republic of ChinaTel +86 18661806185Email nailongy@163.comQing YuDepartment of Endocrinology and Metabolism, Affiliated Hospital of Qingdao University, Qingdao University of Medicine, No. 1677, Wutai Mountain Road, Huangdao District, Qingdao, Shandong 266555, People’s Republic of ChinaEmail yuqing121985@126.comPurpose: To identify the population susceptible to reactive hypoglycemia and explain the possible reasons for their susceptibility.Methods: Ninety-four patients were divided into normal weight, overweight and obese groups before a 75-gram prolonged oral glucose tolerance test (POGTT). The incidence of reactive hypoglycemia (blood glucose ≤ 3.1 mmol/L or 55 mg/dL at points of 0– 4 hours) was compared among three groups, and blood glucose and insulin levels were monitored simultaneously from 0 - 4 hours to assess the level of insulin resistance and insulin sensitivity. Furthermore, the degree of insulin resistance among three groups and within each subgroup (whether hypoglycemia events occurred) was compared.Results: Among the three groups, the incidence of hypoglycemia was significantly different at 3 (P=0.033) and 4 hours (P=0.020). At 4 hours, the incidence of reactive hypoglycemia in the obese group was approximately 3 times that in the normal weight group. The insulin level in obese group at 4 hours was nearly 4 times higher than that in normal group, and the same result also exists in the same subgroup of different groups. In addition, the hypoglycemia subgroup of obese group had higher insulin level than non-hypoglycemia (P=0.000). The homeostasis model assessment of insulin resistance index increased with increasing BMI among the three groups (P=0.000), while the Matsuda index decreased (P=0.000). The comparison of the homeostasis model assessment of insulin resistance index between subgroups in each group showed that the P values were 0.021, 0.038 and 0.085, successively, and the P values for the Matsuda index were 0.019, 0.013 and 0.119, respectively.Conclusion: Obese people has higher rate of reactive hypoglycemia than other groups in POGTT, in which insulin resistance may play an important role. But patients who are evaluated for reactive hypoglycemia need to be observed for at least 3 or 4 hours.Keywords: reactive hypoglycemia, prolonged oral glucose tolerance test, insulin resistance, low-carb ketogenic dietLv XFang KHao WHan YYang NYu QDove Medical Pressarticlereactive hypoglycemiaprolonged oral glucose tolerance testinsulin resistancelow-carb ketogenic dietSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 4717-4726 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	reactive hypoglycemia prolonged oral glucose tolerance test insulin resistance low-carb ketogenic diet Specialties of internal medicine RC581-951
spellingShingle	reactive hypoglycemia prolonged oral glucose tolerance test insulin resistance low-carb ketogenic diet Specialties of internal medicine RC581-951 Lv X Fang K Hao W Han Y Yang N Yu Q Identification of Reactive Hypoglycemia with Different Basic BMI and Its Causes by Prolonged Oral Glucose Tolerance Test
description	Xue Lv,1 Kun Fang,2 Wenqing Hao,1 Yuxin Han,1 Nailong Yang,1 Qing Yu1 1Department of Endocrinology and Metabolism, Affiliated Hospital of Qingdao University, Qingdao, Shandong, People’s Republic of China; 2Division of Health Management Center, Qingdao Municipal Hospital, Qingdao, Shandong, People’s Republic of ChinaCorrespondence: Nailong YangDepartment of Endocrinology and Metabolism, Affiliated Hospital of Qingdao University, Qingdao University of Medicine, No. 1677, Wutai Mountain Road, Huangdao District, Qingdao, Shandong 266555, People’s Republic of ChinaTel +86 18661806185Email nailongy@163.comQing YuDepartment of Endocrinology and Metabolism, Affiliated Hospital of Qingdao University, Qingdao University of Medicine, No. 1677, Wutai Mountain Road, Huangdao District, Qingdao, Shandong 266555, People’s Republic of ChinaEmail yuqing121985@126.comPurpose: To identify the population susceptible to reactive hypoglycemia and explain the possible reasons for their susceptibility.Methods: Ninety-four patients were divided into normal weight, overweight and obese groups before a 75-gram prolonged oral glucose tolerance test (POGTT). The incidence of reactive hypoglycemia (blood glucose ≤ 3.1 mmol/L or 55 mg/dL at points of 0– 4 hours) was compared among three groups, and blood glucose and insulin levels were monitored simultaneously from 0 - 4 hours to assess the level of insulin resistance and insulin sensitivity. Furthermore, the degree of insulin resistance among three groups and within each subgroup (whether hypoglycemia events occurred) was compared.Results: Among the three groups, the incidence of hypoglycemia was significantly different at 3 (P=0.033) and 4 hours (P=0.020). At 4 hours, the incidence of reactive hypoglycemia in the obese group was approximately 3 times that in the normal weight group. The insulin level in obese group at 4 hours was nearly 4 times higher than that in normal group, and the same result also exists in the same subgroup of different groups. In addition, the hypoglycemia subgroup of obese group had higher insulin level than non-hypoglycemia (P=0.000). The homeostasis model assessment of insulin resistance index increased with increasing BMI among the three groups (P=0.000), while the Matsuda index decreased (P=0.000). The comparison of the homeostasis model assessment of insulin resistance index between subgroups in each group showed that the P values were 0.021, 0.038 and 0.085, successively, and the P values for the Matsuda index were 0.019, 0.013 and 0.119, respectively.Conclusion: Obese people has higher rate of reactive hypoglycemia than other groups in POGTT, in which insulin resistance may play an important role. But patients who are evaluated for reactive hypoglycemia need to be observed for at least 3 or 4 hours.Keywords: reactive hypoglycemia, prolonged oral glucose tolerance test, insulin resistance, low-carb ketogenic diet
format	article
author	Lv X Fang K Hao W Han Y Yang N Yu Q
author_facet	Lv X Fang K Hao W Han Y Yang N Yu Q
author_sort	Lv X
title	Identification of Reactive Hypoglycemia with Different Basic BMI and Its Causes by Prolonged Oral Glucose Tolerance Test
title_short	Identification of Reactive Hypoglycemia with Different Basic BMI and Its Causes by Prolonged Oral Glucose Tolerance Test
title_full	Identification of Reactive Hypoglycemia with Different Basic BMI and Its Causes by Prolonged Oral Glucose Tolerance Test
title_fullStr	Identification of Reactive Hypoglycemia with Different Basic BMI and Its Causes by Prolonged Oral Glucose Tolerance Test
title_full_unstemmed	Identification of Reactive Hypoglycemia with Different Basic BMI and Its Causes by Prolonged Oral Glucose Tolerance Test
title_sort	identification of reactive hypoglycemia with different basic bmi and its causes by prolonged oral glucose tolerance test
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/34fa62557b054ecbab3073bdb952df72
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Identification of Reactive Hypoglycemia with Different Basic BMI and Its Causes by Prolonged Oral Glucose Tolerance Test

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