Longitudinal association between CRP levels and risk of psychosis: a meta-analysis of population-based cohort studies

Abstract Meta-analyses of cross-sectional studies suggest that patients with psychosis have higher circulating levels of C-reactive protein (CRP) compared with healthy controls; however, cause and effect is unclear. We examined the prospective association between CRP levels and subsequent risk of de...

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Autores principales:	Emanuele F. Osimo, Luke Baxter, Jan Stochl, Benjamin I. Perry, Stephen A. Metcalf, Setor K. Kunutsor, Jari A. Laukkanen, Marie Kim Wium-Andersen, Peter B. Jones, Golam M. Khandaker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/34fac0cb5f19474f996fc76e386941c2
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spelling	oai:doaj.org-article:34fac0cb5f19474f996fc76e386941c22021-12-02T14:49:23ZLongitudinal association between CRP levels and risk of psychosis: a meta-analysis of population-based cohort studies10.1038/s41537-021-00161-42334-265Xhttps://doaj.org/article/34fac0cb5f19474f996fc76e386941c22021-05-01T00:00:00Zhttps://doi.org/10.1038/s41537-021-00161-4https://doaj.org/toc/2334-265XAbstract Meta-analyses of cross-sectional studies suggest that patients with psychosis have higher circulating levels of C-reactive protein (CRP) compared with healthy controls; however, cause and effect is unclear. We examined the prospective association between CRP levels and subsequent risk of developing a psychotic disorder by conducting a systematic review and meta-analysis of population-based cohort studies. Databases were searched for prospective studies of CRP and psychosis. We obtained unpublished results, including adjustment for age, sex, body mass index, smoking, alcohol use, and socioeconomic status and suspected infection (CRP > 10 mg/L). Based on random effect meta-analysis of 89,792 participants (494 incident cases of psychosis at follow-up), the pooled odds ratio (OR) for psychosis for participants with high (>3 mg/L), as compared to low (≤3 mg/L) CRP levels at baseline was 1.50 (95% confidence interval [CI], 1.09–2.07). Evidence for this association remained after adjusting for potential confounders (adjusted OR [aOR] = 1.31; 95% CI, 1.03–1.66). After excluding participants with suspected infection, the OR for psychosis was 1.36 (95% CI, 1.06–1.74), but the association attenuated after controlling for confounders (aOR = 1.23; 95% CI, 0.95–1.60). Using CRP as a continuous variable, the pooled OR for psychosis per standard deviation increase in log(CRP) was 1.11 (95% CI, 0.93–1.34), and this association further attenuated after controlling for confounders (aOR = 1.07; 95% CI, 0.90–1.27) and excluding participants with suspected infection (aOR = 1.07; 95% CI, 0.92–1.24). There was no association using CRP as a categorical variable (low, medium or high). While we provide some evidence of a longitudinal association between high CRP (>3 mg/L) and psychosis, larger studies are required to enable definitive conclusions.Emanuele F. OsimoLuke BaxterJan StochlBenjamin I. PerryStephen A. MetcalfSetor K. KunutsorJari A. LaukkanenMarie Kim Wium-AndersenPeter B. JonesGolam M. KhandakerNature PortfolioarticlePsychiatryRC435-571ENnpj Schizophrenia, Vol 7, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psychiatry RC435-571
spellingShingle	Psychiatry RC435-571 Emanuele F. Osimo Luke Baxter Jan Stochl Benjamin I. Perry Stephen A. Metcalf Setor K. Kunutsor Jari A. Laukkanen Marie Kim Wium-Andersen Peter B. Jones Golam M. Khandaker Longitudinal association between CRP levels and risk of psychosis: a meta-analysis of population-based cohort studies
description	Abstract Meta-analyses of cross-sectional studies suggest that patients with psychosis have higher circulating levels of C-reactive protein (CRP) compared with healthy controls; however, cause and effect is unclear. We examined the prospective association between CRP levels and subsequent risk of developing a psychotic disorder by conducting a systematic review and meta-analysis of population-based cohort studies. Databases were searched for prospective studies of CRP and psychosis. We obtained unpublished results, including adjustment for age, sex, body mass index, smoking, alcohol use, and socioeconomic status and suspected infection (CRP > 10 mg/L). Based on random effect meta-analysis of 89,792 participants (494 incident cases of psychosis at follow-up), the pooled odds ratio (OR) for psychosis for participants with high (>3 mg/L), as compared to low (≤3 mg/L) CRP levels at baseline was 1.50 (95% confidence interval [CI], 1.09–2.07). Evidence for this association remained after adjusting for potential confounders (adjusted OR [aOR] = 1.31; 95% CI, 1.03–1.66). After excluding participants with suspected infection, the OR for psychosis was 1.36 (95% CI, 1.06–1.74), but the association attenuated after controlling for confounders (aOR = 1.23; 95% CI, 0.95–1.60). Using CRP as a continuous variable, the pooled OR for psychosis per standard deviation increase in log(CRP) was 1.11 (95% CI, 0.93–1.34), and this association further attenuated after controlling for confounders (aOR = 1.07; 95% CI, 0.90–1.27) and excluding participants with suspected infection (aOR = 1.07; 95% CI, 0.92–1.24). There was no association using CRP as a categorical variable (low, medium or high). While we provide some evidence of a longitudinal association between high CRP (>3 mg/L) and psychosis, larger studies are required to enable definitive conclusions.
format	article
author	Emanuele F. Osimo Luke Baxter Jan Stochl Benjamin I. Perry Stephen A. Metcalf Setor K. Kunutsor Jari A. Laukkanen Marie Kim Wium-Andersen Peter B. Jones Golam M. Khandaker
author_facet	Emanuele F. Osimo Luke Baxter Jan Stochl Benjamin I. Perry Stephen A. Metcalf Setor K. Kunutsor Jari A. Laukkanen Marie Kim Wium-Andersen Peter B. Jones Golam M. Khandaker
author_sort	Emanuele F. Osimo
title	Longitudinal association between CRP levels and risk of psychosis: a meta-analysis of population-based cohort studies
title_short	Longitudinal association between CRP levels and risk of psychosis: a meta-analysis of population-based cohort studies
title_full	Longitudinal association between CRP levels and risk of psychosis: a meta-analysis of population-based cohort studies
title_fullStr	Longitudinal association between CRP levels and risk of psychosis: a meta-analysis of population-based cohort studies
title_full_unstemmed	Longitudinal association between CRP levels and risk of psychosis: a meta-analysis of population-based cohort studies
title_sort	longitudinal association between crp levels and risk of psychosis: a meta-analysis of population-based cohort studies
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/34fac0cb5f19474f996fc76e386941c2
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_version_	1718389502710382592

Longitudinal association between CRP levels and risk of psychosis: a meta-analysis of population-based cohort studies

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