Salivary testosterone measurement in women with and without polycystic ovary syndrome

Abstract Clinical and/or biochemical hyperandrogenism is one of the diagnostic criteria for PCOS. An evaluation of the role of salivary testosterone (salT) and androstenedione (salA) for the diagnosis of PCOS was undertaken in a cross sectional study involving 65 women without PCOS and 110 women wit...

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Autores principales:	Thozhukat Sathyapalan, Ahmed Al-Qaissi, Eric S. Kilpatrick, Soha R. Dargham, Joanne Adaway, Brian Keevil, Stephen L. Atkin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/34fff71c18c34878864e74abc66742e5
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spelling	oai:doaj.org-article:34fff71c18c34878864e74abc66742e52021-12-02T11:52:26ZSalivary testosterone measurement in women with and without polycystic ovary syndrome10.1038/s41598-017-03945-w2045-2322https://doaj.org/article/34fff71c18c34878864e74abc66742e52017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03945-whttps://doaj.org/toc/2045-2322Abstract Clinical and/or biochemical hyperandrogenism is one of the diagnostic criteria for PCOS. An evaluation of the role of salivary testosterone (salT) and androstenedione (salA) for the diagnosis of PCOS was undertaken in a cross sectional study involving 65 women without PCOS and 110 women with PCOS fulfilling all 3 diagnostic Rotterdam criteria. Serum and salivary androgen measurements were determined by LC-MS/MS. salT and salA were significantly elevated in PCOS compared to controls (P < 001). No androgen marker was more predictive than another using ROC curves, but multiple logistic regression suggested salT was more predictive than free androgen index (FAI) (p < 0.01). The combination of salT or FAI identified 100% of PCOS women. PCOS women with both biochemical and clinical hyperandrogenism as opposed to clinical hyperandrogenism alone showed a metabolic phenotype (p < 0.05) and insulin resistance (p < 0.001). PCOS patients with an isolated elevated FAI showed increased insulin resistance compared to those with an isolated salT (P < 0.05). salT appeared to be at least as predictive as FAI for the diagnosis of the classical PCOS phenotype, and the combination of salT or FAI identified 100% of PCOS patients. This suggests that salT measurement by LC-MS/MS holds the promise of complementing existing laboratory tests as a means of assessing hyperandrogenemia.Thozhukat SathyapalanAhmed Al-QaissiEric S. KilpatrickSoha R. DarghamJoanne AdawayBrian KeevilStephen L. AtkinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Thozhukat Sathyapalan Ahmed Al-Qaissi Eric S. Kilpatrick Soha R. Dargham Joanne Adaway Brian Keevil Stephen L. Atkin Salivary testosterone measurement in women with and without polycystic ovary syndrome
description	Abstract Clinical and/or biochemical hyperandrogenism is one of the diagnostic criteria for PCOS. An evaluation of the role of salivary testosterone (salT) and androstenedione (salA) for the diagnosis of PCOS was undertaken in a cross sectional study involving 65 women without PCOS and 110 women with PCOS fulfilling all 3 diagnostic Rotterdam criteria. Serum and salivary androgen measurements were determined by LC-MS/MS. salT and salA were significantly elevated in PCOS compared to controls (P < 001). No androgen marker was more predictive than another using ROC curves, but multiple logistic regression suggested salT was more predictive than free androgen index (FAI) (p < 0.01). The combination of salT or FAI identified 100% of PCOS women. PCOS women with both biochemical and clinical hyperandrogenism as opposed to clinical hyperandrogenism alone showed a metabolic phenotype (p < 0.05) and insulin resistance (p < 0.001). PCOS patients with an isolated elevated FAI showed increased insulin resistance compared to those with an isolated salT (P < 0.05). salT appeared to be at least as predictive as FAI for the diagnosis of the classical PCOS phenotype, and the combination of salT or FAI identified 100% of PCOS patients. This suggests that salT measurement by LC-MS/MS holds the promise of complementing existing laboratory tests as a means of assessing hyperandrogenemia.
format	article
author	Thozhukat Sathyapalan Ahmed Al-Qaissi Eric S. Kilpatrick Soha R. Dargham Joanne Adaway Brian Keevil Stephen L. Atkin
author_facet	Thozhukat Sathyapalan Ahmed Al-Qaissi Eric S. Kilpatrick Soha R. Dargham Joanne Adaway Brian Keevil Stephen L. Atkin
author_sort	Thozhukat Sathyapalan
title	Salivary testosterone measurement in women with and without polycystic ovary syndrome
title_short	Salivary testosterone measurement in women with and without polycystic ovary syndrome
title_full	Salivary testosterone measurement in women with and without polycystic ovary syndrome
title_fullStr	Salivary testosterone measurement in women with and without polycystic ovary syndrome
title_full_unstemmed	Salivary testosterone measurement in women with and without polycystic ovary syndrome
title_sort	salivary testosterone measurement in women with and without polycystic ovary syndrome
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/34fff71c18c34878864e74abc66742e5
work_keys_str_mv	AT thozhukatsathyapalan salivarytestosteronemeasurementinwomenwithandwithoutpolycysticovarysyndrome AT ahmedalqaissi salivarytestosteronemeasurementinwomenwithandwithoutpolycysticovarysyndrome AT ericskilpatrick salivarytestosteronemeasurementinwomenwithandwithoutpolycysticovarysyndrome AT sohardargham salivarytestosteronemeasurementinwomenwithandwithoutpolycysticovarysyndrome AT joanneadaway salivarytestosteronemeasurementinwomenwithandwithoutpolycysticovarysyndrome AT briankeevil salivarytestosteronemeasurementinwomenwithandwithoutpolycysticovarysyndrome AT stephenlatkin salivarytestosteronemeasurementinwomenwithandwithoutpolycysticovarysyndrome
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Salivary testosterone measurement in women with and without polycystic ovary syndrome

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