Cerebral vasculogenesis in rat newborns

Background and objective: Vascularization of the developing vertebrate brain occurs exclusively via angiogenesis and formation of new blood vessels from existing vasculature capillaries originating in the cortical brain perineural vascular plexus. In this study, vasculogenesis in cerebral cortex of...

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Auteurs principaux:	MR Nik Ravesh, M Jalali
Format:	article
Langue:	EN FA
Publié:	Babol University of Medical Sciences 2005
Sujets:	vasculogenesis cerebral cortex stereology rat Medicine R Medicine (General) R5-920
Accès en ligne:	https://doaj.org/article/35024956b8c445808ce505b12752c22b
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spelling	oai:doaj.org-article:35024956b8c445808ce505b12752c22b2021-11-10T09:14:41ZCerebral vasculogenesis in rat newborns1561-41072251-7170https://doaj.org/article/35024956b8c445808ce505b12752c22b2005-07-01T00:00:00Zhttp://jbums.org/article-1-2617-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Background and objective: Vascularization of the developing vertebrate brain occurs exclusively via angiogenesis and formation of new blood vessels from existing vasculature capillaries originating in the cortical brain perineural vascular plexus. In this study, vasculogenesis in cerebral cortex of rat newborns was investigated. Methods: Newborns wistar rat (Among 5-15 days after birth) were used. After fixation, the brain of all specimens was processed, serially sectioned and vasculogenesis process by using morphometrical methods and histological studies were carried out. The brain blood volume density was measured and after that data were analyzed. Findings: Our finings revealed that in the first phase of vasculogenesis, endothelial cells formed uncanalized buds, which grew out from the boy of a principal artery (PA) and extended to same bud in other blood vessel. Later, primitive vascular lumen developed to a sufficient size to allow for the circulation of blood cells. These processes increased continuously until 8 post-natal days. Conclusion: These data suggested that in the vasculogenesis of cerebral cortex, there are two steps. In the first phase, there is a migration and translocation endothelial cell during vascular bud forming and lead to cellular cords and in the second phase, the primary vascular cords change to vascular endothelial cell chaining and occurring a canalization process among them for blood circulation.MR Nik RaveshM JalaliBabol University of Medical Sciencesarticlevasculogenesiscerebral cortexstereologyratMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 7, Iss 3, Pp 27-33 (2005)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	vasculogenesis cerebral cortex stereology rat Medicine R Medicine (General) R5-920
spellingShingle	vasculogenesis cerebral cortex stereology rat Medicine R Medicine (General) R5-920 MR Nik Ravesh M Jalali Cerebral vasculogenesis in rat newborns
description	Background and objective: Vascularization of the developing vertebrate brain occurs exclusively via angiogenesis and formation of new blood vessels from existing vasculature capillaries originating in the cortical brain perineural vascular plexus. In this study, vasculogenesis in cerebral cortex of rat newborns was investigated. Methods: Newborns wistar rat (Among 5-15 days after birth) were used. After fixation, the brain of all specimens was processed, serially sectioned and vasculogenesis process by using morphometrical methods and histological studies were carried out. The brain blood volume density was measured and after that data were analyzed. Findings: Our finings revealed that in the first phase of vasculogenesis, endothelial cells formed uncanalized buds, which grew out from the boy of a principal artery (PA) and extended to same bud in other blood vessel. Later, primitive vascular lumen developed to a sufficient size to allow for the circulation of blood cells. These processes increased continuously until 8 post-natal days. Conclusion: These data suggested that in the vasculogenesis of cerebral cortex, there are two steps. In the first phase, there is a migration and translocation endothelial cell during vascular bud forming and lead to cellular cords and in the second phase, the primary vascular cords change to vascular endothelial cell chaining and occurring a canalization process among them for blood circulation.
format	article
author	MR Nik Ravesh M Jalali
author_facet	MR Nik Ravesh M Jalali
author_sort	MR Nik Ravesh
title	Cerebral vasculogenesis in rat newborns
title_short	Cerebral vasculogenesis in rat newborns
title_full	Cerebral vasculogenesis in rat newborns
title_fullStr	Cerebral vasculogenesis in rat newborns
title_full_unstemmed	Cerebral vasculogenesis in rat newborns
title_sort	cerebral vasculogenesis in rat newborns
publisher	Babol University of Medical Sciences
publishDate	2005
url	https://doaj.org/article/35024956b8c445808ce505b12752c22b
work_keys_str_mv	AT mrnikravesh cerebralvasculogenesisinratnewborns AT mjalali cerebralvasculogenesisinratnewborns
_version_	1718440179976372224

Cerebral vasculogenesis in rat newborns

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