Effects of dexmedetomidine on renal microcirculation in ischemia/reperfusion-induced acute kidney injury in rats

Abstract Microcirculatory dysfunction plays a crucial role in renal ischemia/reperfusion (IR)-induced injury. Dexmedetomidine was reported to ameliorate IR-induced acute kidney injury. This study investigated the effects of dexmedetomidine on renal microcirculation after IR-induced acute kidney inju...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Szu-Jen Yang, Chia-Ning Fan, Ming-Jiuh Wang, Shou-Zen Fan, Jui-Chang Tsai, Wei-Zen Sun, Wing-Sum Chan, Yu-Chang Yeh, NTUH Center of Microcirculation Medical Research (NCMMR)
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3502e6b27c25449facf02462e92e7a6a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3502e6b27c25449facf02462e92e7a6a
record_format	dspace
spelling	oai:doaj.org-article:3502e6b27c25449facf02462e92e7a6a2021-12-02T10:49:29ZEffects of dexmedetomidine on renal microcirculation in ischemia/reperfusion-induced acute kidney injury in rats10.1038/s41598-021-81288-32045-2322https://doaj.org/article/3502e6b27c25449facf02462e92e7a6a2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81288-3https://doaj.org/toc/2045-2322Abstract Microcirculatory dysfunction plays a crucial role in renal ischemia/reperfusion (IR)-induced injury. Dexmedetomidine was reported to ameliorate IR-induced acute kidney injury. This study investigated the effects of dexmedetomidine on renal microcirculation after IR-induced acute kidney injury in rats. In total, 50 rats were randomly allocated to the following five groups (10 in each group): Sham, Control‒IR, Dex (dexmedetomidine) ‒Sham, Dex‒IR, and IR‒Dex group. The microcirculation parameters included total small vessel density, perfused small vessel density (PSVD), proportion of perfused small vessels, microvascular flow index, and tissue oxygen saturation (StO2) were recorded. The repeated measures analysis showed that PSVD on renal surface was higher in the Dex‒IR group than in the Control‒IR group (3.5 mm/mm2, 95% confidence interval [CI] 0.6 to 6.4 mm/mm2, P = 0.01). At 240 min, StO2 on renal surface was lower in the Control‒IR group than in the Sham group (– 7%, 95% CI − 13 to − 1%, P = 0.021), but StO2 did not differ significantly among the Sham, Dex‒IR, and IR‒Dex groups. Our results showed that pretreatment with dexmedetomidine improved renal microcirculation in rats with IR-induced acute kidney injury. However, the adverse effects of low mean arterial pressure and heart rate might offset the protective effect of dexmedetomidine on organ injury.Szu-Jen YangChia-Ning FanMing-Jiuh WangShou-Zen FanJui-Chang TsaiWei-Zen SunWing-Sum ChanYu-Chang YehNTUH Center of Microcirculation Medical Research (NCMMR)Nature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Szu-Jen Yang Chia-Ning Fan Ming-Jiuh Wang Shou-Zen Fan Jui-Chang Tsai Wei-Zen Sun Wing-Sum Chan Yu-Chang Yeh NTUH Center of Microcirculation Medical Research (NCMMR) Effects of dexmedetomidine on renal microcirculation in ischemia/reperfusion-induced acute kidney injury in rats
description	Abstract Microcirculatory dysfunction plays a crucial role in renal ischemia/reperfusion (IR)-induced injury. Dexmedetomidine was reported to ameliorate IR-induced acute kidney injury. This study investigated the effects of dexmedetomidine on renal microcirculation after IR-induced acute kidney injury in rats. In total, 50 rats were randomly allocated to the following five groups (10 in each group): Sham, Control‒IR, Dex (dexmedetomidine) ‒Sham, Dex‒IR, and IR‒Dex group. The microcirculation parameters included total small vessel density, perfused small vessel density (PSVD), proportion of perfused small vessels, microvascular flow index, and tissue oxygen saturation (StO2) were recorded. The repeated measures analysis showed that PSVD on renal surface was higher in the Dex‒IR group than in the Control‒IR group (3.5 mm/mm2, 95% confidence interval [CI] 0.6 to 6.4 mm/mm2, P = 0.01). At 240 min, StO2 on renal surface was lower in the Control‒IR group than in the Sham group (– 7%, 95% CI − 13 to − 1%, P = 0.021), but StO2 did not differ significantly among the Sham, Dex‒IR, and IR‒Dex groups. Our results showed that pretreatment with dexmedetomidine improved renal microcirculation in rats with IR-induced acute kidney injury. However, the adverse effects of low mean arterial pressure and heart rate might offset the protective effect of dexmedetomidine on organ injury.
format	article
author	Szu-Jen Yang Chia-Ning Fan Ming-Jiuh Wang Shou-Zen Fan Jui-Chang Tsai Wei-Zen Sun Wing-Sum Chan Yu-Chang Yeh NTUH Center of Microcirculation Medical Research (NCMMR)
author_facet	Szu-Jen Yang Chia-Ning Fan Ming-Jiuh Wang Shou-Zen Fan Jui-Chang Tsai Wei-Zen Sun Wing-Sum Chan Yu-Chang Yeh NTUH Center of Microcirculation Medical Research (NCMMR)
author_sort	Szu-Jen Yang
title	Effects of dexmedetomidine on renal microcirculation in ischemia/reperfusion-induced acute kidney injury in rats
title_short	Effects of dexmedetomidine on renal microcirculation in ischemia/reperfusion-induced acute kidney injury in rats
title_full	Effects of dexmedetomidine on renal microcirculation in ischemia/reperfusion-induced acute kidney injury in rats
title_fullStr	Effects of dexmedetomidine on renal microcirculation in ischemia/reperfusion-induced acute kidney injury in rats
title_full_unstemmed	Effects of dexmedetomidine on renal microcirculation in ischemia/reperfusion-induced acute kidney injury in rats
title_sort	effects of dexmedetomidine on renal microcirculation in ischemia/reperfusion-induced acute kidney injury in rats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3502e6b27c25449facf02462e92e7a6a
work_keys_str_mv	AT szujenyang effectsofdexmedetomidineonrenalmicrocirculationinischemiareperfusioninducedacutekidneyinjuryinrats AT chianingfan effectsofdexmedetomidineonrenalmicrocirculationinischemiareperfusioninducedacutekidneyinjuryinrats AT mingjiuhwang effectsofdexmedetomidineonrenalmicrocirculationinischemiareperfusioninducedacutekidneyinjuryinrats AT shouzenfan effectsofdexmedetomidineonrenalmicrocirculationinischemiareperfusioninducedacutekidneyinjuryinrats AT juichangtsai effectsofdexmedetomidineonrenalmicrocirculationinischemiareperfusioninducedacutekidneyinjuryinrats AT weizensun effectsofdexmedetomidineonrenalmicrocirculationinischemiareperfusioninducedacutekidneyinjuryinrats AT wingsumchan effectsofdexmedetomidineonrenalmicrocirculationinischemiareperfusioninducedacutekidneyinjuryinrats AT yuchangyeh effectsofdexmedetomidineonrenalmicrocirculationinischemiareperfusioninducedacutekidneyinjuryinrats AT ntuhcenterofmicrocirculationmedicalresearchncmmr effectsofdexmedetomidineonrenalmicrocirculationinischemiareperfusioninducedacutekidneyinjuryinrats
_version_	1718396581796904960

Effects of dexmedetomidine on renal microcirculation in ischemia/reperfusion-induced acute kidney injury in rats

Ejemplares similares