WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling

WDFY2 is known as a tumour suppressor but its function is unclear. Here, the authors show that WDFY2 interacts with the v-SNARE VAMP3, leading to a suppression of the metalloprotease MT1-MMP secretion, suggesting that WDFY2 acts a tumour suppressor by suppressing MT1-MMP secretion.

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Autores principales:	Marte Sneeggen, Nina Marie Pedersen, Coen Campsteijn, Ellen Margrethe Haugsten, Harald Stenmark, Kay Oliver Schink
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3505811024c5474b96d65acf9533e98e
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spelling	oai:doaj.org-article:3505811024c5474b96d65acf9533e98e2021-12-02T14:38:40ZWDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling10.1038/s41467-019-10794-w2041-1723https://doaj.org/article/3505811024c5474b96d65acf9533e98e2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10794-whttps://doaj.org/toc/2041-1723WDFY2 is known as a tumour suppressor but its function is unclear. Here, the authors show that WDFY2 interacts with the v-SNARE VAMP3, leading to a suppression of the metalloprotease MT1-MMP secretion, suggesting that WDFY2 acts a tumour suppressor by suppressing MT1-MMP secretion.Marte SneeggenNina Marie PedersenCoen CampsteijnEllen Margrethe HaugstenHarald StenmarkKay Oliver SchinkNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marte Sneeggen Nina Marie Pedersen Coen Campsteijn Ellen Margrethe Haugsten Harald Stenmark Kay Oliver Schink WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling
description	WDFY2 is known as a tumour suppressor but its function is unclear. Here, the authors show that WDFY2 interacts with the v-SNARE VAMP3, leading to a suppression of the metalloprotease MT1-MMP secretion, suggesting that WDFY2 acts a tumour suppressor by suppressing MT1-MMP secretion.
format	article
author	Marte Sneeggen Nina Marie Pedersen Coen Campsteijn Ellen Margrethe Haugsten Harald Stenmark Kay Oliver Schink
author_facet	Marte Sneeggen Nina Marie Pedersen Coen Campsteijn Ellen Margrethe Haugsten Harald Stenmark Kay Oliver Schink
author_sort	Marte Sneeggen
title	WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling
title_short	WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling
title_full	WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling
title_fullStr	WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling
title_full_unstemmed	WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling
title_sort	wdfy2 restrains matrix metalloproteinase secretion and cell invasion by controlling vamp3-dependent recycling
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3505811024c5474b96d65acf9533e98e
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WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling

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