Heart Failure and Cancer: Mechanisms of Old and New Cardiotoxic Drugs in Cancer Patients

Although there have been many improvements in prognosis for patients with cancer, anticancer therapies are burdened by the risk of cardiovascular toxicity. Heart failure is one of the most dramatic clinical expressions of cardiotoxicity, and it may occur acutely or appear years after treatment. This...

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Autores principales:	Alessandra Cuomo, Alessio Rodolico, Amalia Galdieri, Michele Russo, Giacomo Campi, Riccardo Franco, Dalila Bruno, Luisa Aran, Antonio Carannante, Umberto Attanasio, Carlo G Tocchetti, Gilda Varricchi, Valentina Mercurio
Formato:	article
Lenguaje:	EN
Publicado:	Radcliffe Medical Media 2019
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/350633c3d3f44e04b7903c622d9e8c1e
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spelling	oai:doaj.org-article:350633c3d3f44e04b7903c622d9e8c1e2021-12-04T16:01:37ZHeart Failure and Cancer: Mechanisms of Old and New Cardiotoxic Drugs in Cancer Patients10.15420/cfr.2018.32.22057-75592057-7540https://doaj.org/article/350633c3d3f44e04b7903c622d9e8c1e2019-05-01T00:00:00Zhttps://www.cfrjournal.com/articles/Heart-Failure-Cancer-Cardiotoxic-Drugshttps://doaj.org/toc/2057-7540https://doaj.org/toc/2057-7559Although there have been many improvements in prognosis for patients with cancer, anticancer therapies are burdened by the risk of cardiovascular toxicity. Heart failure is one of the most dramatic clinical expressions of cardiotoxicity, and it may occur acutely or appear years after treatment. This article reviews the main mechanisms and clinical presentations of left ventricular dysfunction induced by some old and new cardiotoxic drugs in cancer patients, referring to the most recent advances in the field. The authors describe the mechanisms of cardiotoxicity induced by anthracyclines, which can lead to cardiovascular problems in up to 48% of patients who take them. The authors also describe mechanisms of cardiotoxicity induced by biological drugs that produce left ventricular dysfunction through secondary mechanisms. They outline the recent advances in immunotherapies, which have revolutionised anticancer therapies.Alessandra CuomoAlessio RodolicoAmalia GaldieriMichele RussoGiacomo CampiRiccardo FrancoDalila BrunoLuisa AranAntonio CarannanteUmberto AttanasioCarlo G TocchettiGilda VarricchiValentina MercurioRadcliffe Medical MediaarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENCardiac Failure Review , Vol 5, Iss 2, Pp 112-118 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Alessandra Cuomo Alessio Rodolico Amalia Galdieri Michele Russo Giacomo Campi Riccardo Franco Dalila Bruno Luisa Aran Antonio Carannante Umberto Attanasio Carlo G Tocchetti Gilda Varricchi Valentina Mercurio Heart Failure and Cancer: Mechanisms of Old and New Cardiotoxic Drugs in Cancer Patients
description	Although there have been many improvements in prognosis for patients with cancer, anticancer therapies are burdened by the risk of cardiovascular toxicity. Heart failure is one of the most dramatic clinical expressions of cardiotoxicity, and it may occur acutely or appear years after treatment. This article reviews the main mechanisms and clinical presentations of left ventricular dysfunction induced by some old and new cardiotoxic drugs in cancer patients, referring to the most recent advances in the field. The authors describe the mechanisms of cardiotoxicity induced by anthracyclines, which can lead to cardiovascular problems in up to 48% of patients who take them. The authors also describe mechanisms of cardiotoxicity induced by biological drugs that produce left ventricular dysfunction through secondary mechanisms. They outline the recent advances in immunotherapies, which have revolutionised anticancer therapies.
format	article
author	Alessandra Cuomo Alessio Rodolico Amalia Galdieri Michele Russo Giacomo Campi Riccardo Franco Dalila Bruno Luisa Aran Antonio Carannante Umberto Attanasio Carlo G Tocchetti Gilda Varricchi Valentina Mercurio
author_facet	Alessandra Cuomo Alessio Rodolico Amalia Galdieri Michele Russo Giacomo Campi Riccardo Franco Dalila Bruno Luisa Aran Antonio Carannante Umberto Attanasio Carlo G Tocchetti Gilda Varricchi Valentina Mercurio
author_sort	Alessandra Cuomo
title	Heart Failure and Cancer: Mechanisms of Old and New Cardiotoxic Drugs in Cancer Patients
title_short	Heart Failure and Cancer: Mechanisms of Old and New Cardiotoxic Drugs in Cancer Patients
title_full	Heart Failure and Cancer: Mechanisms of Old and New Cardiotoxic Drugs in Cancer Patients
title_fullStr	Heart Failure and Cancer: Mechanisms of Old and New Cardiotoxic Drugs in Cancer Patients
title_full_unstemmed	Heart Failure and Cancer: Mechanisms of Old and New Cardiotoxic Drugs in Cancer Patients
title_sort	heart failure and cancer: mechanisms of old and new cardiotoxic drugs in cancer patients
publisher	Radcliffe Medical Media
publishDate	2019
url	https://doaj.org/article/350633c3d3f44e04b7903c622d9e8c1e
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Heart Failure and Cancer: Mechanisms of Old and New Cardiotoxic Drugs in Cancer Patients

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