Mutation Rate Simulation by Dice Roll: Practice with the Drake Equation

Spontaneous mutation, or random genetic change during normal organism function, and random mutagenesis are widely employed by biologists to investigate cell function. The mutation rate of any genetic locus is commonly defined as the probability of mutation μ = M/N. That is, the number of mutations i...

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Autores principales:	Pryce L. Haddix, Clark A. Danderson
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	Special aspects of education LC8-6691 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/35086a080cbf426fbc99b4bae4cb9e69
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spelling	oai:doaj.org-article:35086a080cbf426fbc99b4bae4cb9e692021-11-15T15:04:11ZMutation Rate Simulation by Dice Roll: Practice with the Drake Equation10.1128/jmbe.v19i2.15491935-78851935-7877https://doaj.org/article/35086a080cbf426fbc99b4bae4cb9e692018-01-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/jmbe.v19i2.1549https://doaj.org/toc/1935-7877https://doaj.org/toc/1935-7885Spontaneous mutation, or random genetic change during normal organism function, and random mutagenesis are widely employed by biologists to investigate cell function. The mutation rate of any genetic locus is commonly defined as the probability of mutation μ = M/N. That is, the number of mutations is assumed to be equal to the number of mutant organisms M following N cell division events to produce a population size of N + 1 cells. Measuring the rate of mutant organism production is technically cumbersome due to the need to quantify both mutant and total cell numbers from multiple independent cultures; such measurements are often not feasible for the undergraduate biology laboratory. We present here a simple classroom probability exercise that simulates the production of mutant organisms and measures mutation rate using the Drake equation. This exercise and data analysis may be completed in one hour’s time and without microbial cultivation.Pryce L. HaddixClark A. DandersonAmerican Society for MicrobiologyarticleSpecial aspects of educationLC8-6691Biology (General)QH301-705.5ENJournal of Microbiology & Biology Education, Vol 19, Iss 2 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Special aspects of education LC8-6691 Biology (General) QH301-705.5
spellingShingle	Special aspects of education LC8-6691 Biology (General) QH301-705.5 Pryce L. Haddix Clark A. Danderson Mutation Rate Simulation by Dice Roll: Practice with the Drake Equation
description	Spontaneous mutation, or random genetic change during normal organism function, and random mutagenesis are widely employed by biologists to investigate cell function. The mutation rate of any genetic locus is commonly defined as the probability of mutation μ = M/N. That is, the number of mutations is assumed to be equal to the number of mutant organisms M following N cell division events to produce a population size of N + 1 cells. Measuring the rate of mutant organism production is technically cumbersome due to the need to quantify both mutant and total cell numbers from multiple independent cultures; such measurements are often not feasible for the undergraduate biology laboratory. We present here a simple classroom probability exercise that simulates the production of mutant organisms and measures mutation rate using the Drake equation. This exercise and data analysis may be completed in one hour’s time and without microbial cultivation.
format	article
author	Pryce L. Haddix Clark A. Danderson
author_facet	Pryce L. Haddix Clark A. Danderson
author_sort	Pryce L. Haddix
title	Mutation Rate Simulation by Dice Roll: Practice with the Drake Equation
title_short	Mutation Rate Simulation by Dice Roll: Practice with the Drake Equation
title_full	Mutation Rate Simulation by Dice Roll: Practice with the Drake Equation
title_fullStr	Mutation Rate Simulation by Dice Roll: Practice with the Drake Equation
title_full_unstemmed	Mutation Rate Simulation by Dice Roll: Practice with the Drake Equation
title_sort	mutation rate simulation by dice roll: practice with the drake equation
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/35086a080cbf426fbc99b4bae4cb9e69
work_keys_str_mv	AT prycelhaddix mutationratesimulationbydicerollpracticewiththedrakeequation AT clarkadanderson mutationratesimulationbydicerollpracticewiththedrakeequation
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Mutation Rate Simulation by Dice Roll: Practice with the Drake Equation

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