Structural basis for active single and double ring complexes in human mitochondrial Hsp60-Hsp10 chaperonin

The mHsp60-mHsp10 chaperonin system forms alternating single and double ring complexes to assist protein folding, but the molecular details of this cycle are not fully understood. Here, the authors present cryoEM and crystal structures of key intermediates of the mHsp60-mHsp10 reaction cycle.

Guardado en:

Detalles Bibliográficos
Autores principales:	Yacob Gomez-Llorente, Fady Jebara, Malay Patra, Radhika Malik, Shahar Nisemblat, Orna Chomsky-Hecht, Avital Parnas, Abdussalam Azem, Joel A. Hirsch, Iban Ubarretxena-Belandia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/350b4f4502ee4f4abafe17203699bcde
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:350b4f4502ee4f4abafe17203699bcde
record_format	dspace
spelling	oai:doaj.org-article:350b4f4502ee4f4abafe17203699bcde2021-12-02T14:41:03ZStructural basis for active single and double ring complexes in human mitochondrial Hsp60-Hsp10 chaperonin10.1038/s41467-020-15698-82041-1723https://doaj.org/article/350b4f4502ee4f4abafe17203699bcde2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15698-8https://doaj.org/toc/2041-1723The mHsp60-mHsp10 chaperonin system forms alternating single and double ring complexes to assist protein folding, but the molecular details of this cycle are not fully understood. Here, the authors present cryoEM and crystal structures of key intermediates of the mHsp60-mHsp10 reaction cycle.Yacob Gomez-LlorenteFady JebaraMalay PatraRadhika MalikShahar NisemblatOrna Chomsky-HechtAvital ParnasAbdussalam AzemJoel A. HirschIban Ubarretxena-BelandiaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yacob Gomez-Llorente Fady Jebara Malay Patra Radhika Malik Shahar Nisemblat Orna Chomsky-Hecht Avital Parnas Abdussalam Azem Joel A. Hirsch Iban Ubarretxena-Belandia Structural basis for active single and double ring complexes in human mitochondrial Hsp60-Hsp10 chaperonin
description	The mHsp60-mHsp10 chaperonin system forms alternating single and double ring complexes to assist protein folding, but the molecular details of this cycle are not fully understood. Here, the authors present cryoEM and crystal structures of key intermediates of the mHsp60-mHsp10 reaction cycle.
format	article
author	Yacob Gomez-Llorente Fady Jebara Malay Patra Radhika Malik Shahar Nisemblat Orna Chomsky-Hecht Avital Parnas Abdussalam Azem Joel A. Hirsch Iban Ubarretxena-Belandia
author_facet	Yacob Gomez-Llorente Fady Jebara Malay Patra Radhika Malik Shahar Nisemblat Orna Chomsky-Hecht Avital Parnas Abdussalam Azem Joel A. Hirsch Iban Ubarretxena-Belandia
author_sort	Yacob Gomez-Llorente
title	Structural basis for active single and double ring complexes in human mitochondrial Hsp60-Hsp10 chaperonin
title_short	Structural basis for active single and double ring complexes in human mitochondrial Hsp60-Hsp10 chaperonin
title_full	Structural basis for active single and double ring complexes in human mitochondrial Hsp60-Hsp10 chaperonin
title_fullStr	Structural basis for active single and double ring complexes in human mitochondrial Hsp60-Hsp10 chaperonin
title_full_unstemmed	Structural basis for active single and double ring complexes in human mitochondrial Hsp60-Hsp10 chaperonin
title_sort	structural basis for active single and double ring complexes in human mitochondrial hsp60-hsp10 chaperonin
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/350b4f4502ee4f4abafe17203699bcde
work_keys_str_mv	AT yacobgomezllorente structuralbasisforactivesingleanddoubleringcomplexesinhumanmitochondrialhsp60hsp10chaperonin AT fadyjebara structuralbasisforactivesingleanddoubleringcomplexesinhumanmitochondrialhsp60hsp10chaperonin AT malaypatra structuralbasisforactivesingleanddoubleringcomplexesinhumanmitochondrialhsp60hsp10chaperonin AT radhikamalik structuralbasisforactivesingleanddoubleringcomplexesinhumanmitochondrialhsp60hsp10chaperonin AT shaharnisemblat structuralbasisforactivesingleanddoubleringcomplexesinhumanmitochondrialhsp60hsp10chaperonin AT ornachomskyhecht structuralbasisforactivesingleanddoubleringcomplexesinhumanmitochondrialhsp60hsp10chaperonin AT avitalparnas structuralbasisforactivesingleanddoubleringcomplexesinhumanmitochondrialhsp60hsp10chaperonin AT abdussalamazem structuralbasisforactivesingleanddoubleringcomplexesinhumanmitochondrialhsp60hsp10chaperonin AT joelahirsch structuralbasisforactivesingleanddoubleringcomplexesinhumanmitochondrialhsp60hsp10chaperonin AT ibanubarretxenabelandia structuralbasisforactivesingleanddoubleringcomplexesinhumanmitochondrialhsp60hsp10chaperonin
_version_	1718390044696248320

Structural basis for active single and double ring complexes in human mitochondrial Hsp60-Hsp10 chaperonin

Ejemplares similares