The Versatile Gasdermin Family: Their Function and Roles in Diseases
The gasdermin (GSDM) family, a novel group of structure-related proteins, consists of GSDMA, GSDMB, GSDMC, GSDMD, GSDME/DNFA5, and PVJK/GSDMF. GSDMs possess a C-terminal repressor domain, cytotoxic N-terminal domain, and flexible linker domain (except for GSDMF). The GSDM-NT domain can be cleaved an...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:350bc5387b6d4f9ca6774060f3b98e5e2021-11-11T09:21:08ZThe Versatile Gasdermin Family: Their Function and Roles in Diseases1664-322410.3389/fimmu.2021.751533https://doaj.org/article/350bc5387b6d4f9ca6774060f3b98e5e2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.751533/fullhttps://doaj.org/toc/1664-3224The gasdermin (GSDM) family, a novel group of structure-related proteins, consists of GSDMA, GSDMB, GSDMC, GSDMD, GSDME/DNFA5, and PVJK/GSDMF. GSDMs possess a C-terminal repressor domain, cytotoxic N-terminal domain, and flexible linker domain (except for GSDMF). The GSDM-NT domain can be cleaved and released to form large oligomeric pores in the membrane that facilitate pyroptosis. The emerging roles of GSDMs include the regulation of various physiological and pathological processes, such as cell differentiation, coagulation, inflammation, and tumorigenesis. Here, we introduce the basic structure, activation, and expression patterns of GSDMs, summarize their biological and pathological functions, and explore their regulatory mechanisms in health and disease. This review provides a reference for the development of GSDM-targeted drugs to treat various inflammatory and tissue damage-related conditions.Ju ZouJu ZouYixiang ZhengYixiang ZhengYan HuangYan HuangDaolin TangRui KangRuochan ChenRuochan ChenFrontiers Media S.A.articlegasderminfamily genefunctionstructureGSDMDImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
gasdermin family gene function structure GSDMD Immunologic diseases. Allergy RC581-607 |
| spellingShingle |
gasdermin family gene function structure GSDMD Immunologic diseases. Allergy RC581-607 Ju Zou Ju Zou Yixiang Zheng Yixiang Zheng Yan Huang Yan Huang Daolin Tang Rui Kang Ruochan Chen Ruochan Chen The Versatile Gasdermin Family: Their Function and Roles in Diseases |
| description |
The gasdermin (GSDM) family, a novel group of structure-related proteins, consists of GSDMA, GSDMB, GSDMC, GSDMD, GSDME/DNFA5, and PVJK/GSDMF. GSDMs possess a C-terminal repressor domain, cytotoxic N-terminal domain, and flexible linker domain (except for GSDMF). The GSDM-NT domain can be cleaved and released to form large oligomeric pores in the membrane that facilitate pyroptosis. The emerging roles of GSDMs include the regulation of various physiological and pathological processes, such as cell differentiation, coagulation, inflammation, and tumorigenesis. Here, we introduce the basic structure, activation, and expression patterns of GSDMs, summarize their biological and pathological functions, and explore their regulatory mechanisms in health and disease. This review provides a reference for the development of GSDM-targeted drugs to treat various inflammatory and tissue damage-related conditions. |
| format |
article |
| author |
Ju Zou Ju Zou Yixiang Zheng Yixiang Zheng Yan Huang Yan Huang Daolin Tang Rui Kang Ruochan Chen Ruochan Chen |
| author_facet |
Ju Zou Ju Zou Yixiang Zheng Yixiang Zheng Yan Huang Yan Huang Daolin Tang Rui Kang Ruochan Chen Ruochan Chen |
| author_sort |
Ju Zou |
| title |
The Versatile Gasdermin Family: Their Function and Roles in Diseases |
| title_short |
The Versatile Gasdermin Family: Their Function and Roles in Diseases |
| title_full |
The Versatile Gasdermin Family: Their Function and Roles in Diseases |
| title_fullStr |
The Versatile Gasdermin Family: Their Function and Roles in Diseases |
| title_full_unstemmed |
The Versatile Gasdermin Family: Their Function and Roles in Diseases |
| title_sort |
versatile gasdermin family: their function and roles in diseases |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/350bc5387b6d4f9ca6774060f3b98e5e |
| work_keys_str_mv |
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