Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response

The role of Endonuclease G in autophagy remains unclear. Here the authors report that ENDOG is released from mitochondria during starvation and promotes autophagy by suppressing mTOR signaling and activating DNA damage response.

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Autores principales:	Wenjun Wang, Jianshuang Li, Junyang Tan, Miaomiao Wang, Jing Yang, Zhi-Min Zhang, Chuanzhou Li, Alexei G. Basnakian, Hong-Wen Tang, Norbert Perrimon, Qinghua Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/350ee72370584337b6076ca9cb427330
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spelling	oai:doaj.org-article:350ee72370584337b6076ca9cb4273302021-12-02T10:49:32ZEndonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response10.1038/s41467-020-20780-22041-1723https://doaj.org/article/350ee72370584337b6076ca9cb4273302021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20780-2https://doaj.org/toc/2041-1723The role of Endonuclease G in autophagy remains unclear. Here the authors report that ENDOG is released from mitochondria during starvation and promotes autophagy by suppressing mTOR signaling and activating DNA damage response.Wenjun WangJianshuang LiJunyang TanMiaomiao WangJing YangZhi-Min ZhangChuanzhou LiAlexei G. BasnakianHong-Wen TangNorbert PerrimonQinghua ZhouNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenjun Wang Jianshuang Li Junyang Tan Miaomiao Wang Jing Yang Zhi-Min Zhang Chuanzhou Li Alexei G. Basnakian Hong-Wen Tang Norbert Perrimon Qinghua Zhou Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response
description	The role of Endonuclease G in autophagy remains unclear. Here the authors report that ENDOG is released from mitochondria during starvation and promotes autophagy by suppressing mTOR signaling and activating DNA damage response.
format	article
author	Wenjun Wang Jianshuang Li Junyang Tan Miaomiao Wang Jing Yang Zhi-Min Zhang Chuanzhou Li Alexei G. Basnakian Hong-Wen Tang Norbert Perrimon Qinghua Zhou
author_facet	Wenjun Wang Jianshuang Li Junyang Tan Miaomiao Wang Jing Yang Zhi-Min Zhang Chuanzhou Li Alexei G. Basnakian Hong-Wen Tang Norbert Perrimon Qinghua Zhou
author_sort	Wenjun Wang
title	Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response
title_short	Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response
title_full	Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response
title_fullStr	Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response
title_full_unstemmed	Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response
title_sort	endonuclease g promotes autophagy by suppressing mtor signaling and activating the dna damage response
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/350ee72370584337b6076ca9cb427330
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Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response

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