Immunogenomic pan-cancer landscape reveals immune escape mechanisms and immunoediting histories

Abstract Immune reactions in the tumor microenvironment are an important hallmark of cancer, and emerging immune therapies have been proven effective against several types of cancers. To investigate cancer genome-immune interactions and the role of immunoediting or immune escape mechanisms in cancer...

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Autores principales:	Shinichi Mizuno, Rui Yamaguchi, Takanori Hasegawa, Shuto Hayashi, Masashi Fujita, Fan Zhang, Youngil Koh, Su-Yeon Lee, Sung-Soo Yoon, Eigo Shimizu, Mitsuhiro Komura, Akihiro Fujimoto, Momoko Nagai, Mamoru Kato, Han Liang, Satoru Miyano, Zemin Zhang, Hidewaki Nakagawa, Seiya Imoto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/351129f51da84158b681c55273869ced
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spelling	oai:doaj.org-article:351129f51da84158b681c55273869ced2021-12-02T14:53:48ZImmunogenomic pan-cancer landscape reveals immune escape mechanisms and immunoediting histories10.1038/s41598-021-95287-x2045-2322https://doaj.org/article/351129f51da84158b681c55273869ced2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95287-xhttps://doaj.org/toc/2045-2322Abstract Immune reactions in the tumor microenvironment are an important hallmark of cancer, and emerging immune therapies have been proven effective against several types of cancers. To investigate cancer genome-immune interactions and the role of immunoediting or immune escape mechanisms in cancer development, we analyzed 2834 whole genome and RNA sequencing datasets across 31 distinct tumor types with respect to key immunogenomic aspects and provided comprehensive immunogenomic profiles of pan-cancers. We found that selective copy number changes in immune-related genes may contribute to immune escape. Furthermore, we developed an index of the immunoediting history of each tumor sample based on the information of mutations in exonic regions and pseudogenes and evaluated the immunoediting history of each tumor. Our immuno-genomic analyses of pan-cancers have the potential to identify a subset of tumors with immunogenicity and diverse backgrounds or intrinsic pathways associated with their immune status and immunoediting history.Shinichi MizunoRui YamaguchiTakanori HasegawaShuto HayashiMasashi FujitaFan ZhangYoungil KohSu-Yeon LeeSung-Soo YoonEigo ShimizuMitsuhiro KomuraAkihiro FujimotoMomoko NagaiMamoru KatoHan LiangSatoru MiyanoZemin ZhangHidewaki NakagawaSeiya ImotoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shinichi Mizuno Rui Yamaguchi Takanori Hasegawa Shuto Hayashi Masashi Fujita Fan Zhang Youngil Koh Su-Yeon Lee Sung-Soo Yoon Eigo Shimizu Mitsuhiro Komura Akihiro Fujimoto Momoko Nagai Mamoru Kato Han Liang Satoru Miyano Zemin Zhang Hidewaki Nakagawa Seiya Imoto Immunogenomic pan-cancer landscape reveals immune escape mechanisms and immunoediting histories
description	Abstract Immune reactions in the tumor microenvironment are an important hallmark of cancer, and emerging immune therapies have been proven effective against several types of cancers. To investigate cancer genome-immune interactions and the role of immunoediting or immune escape mechanisms in cancer development, we analyzed 2834 whole genome and RNA sequencing datasets across 31 distinct tumor types with respect to key immunogenomic aspects and provided comprehensive immunogenomic profiles of pan-cancers. We found that selective copy number changes in immune-related genes may contribute to immune escape. Furthermore, we developed an index of the immunoediting history of each tumor sample based on the information of mutations in exonic regions and pseudogenes and evaluated the immunoediting history of each tumor. Our immuno-genomic analyses of pan-cancers have the potential to identify a subset of tumors with immunogenicity and diverse backgrounds or intrinsic pathways associated with their immune status and immunoediting history.
format	article
author	Shinichi Mizuno Rui Yamaguchi Takanori Hasegawa Shuto Hayashi Masashi Fujita Fan Zhang Youngil Koh Su-Yeon Lee Sung-Soo Yoon Eigo Shimizu Mitsuhiro Komura Akihiro Fujimoto Momoko Nagai Mamoru Kato Han Liang Satoru Miyano Zemin Zhang Hidewaki Nakagawa Seiya Imoto
author_facet	Shinichi Mizuno Rui Yamaguchi Takanori Hasegawa Shuto Hayashi Masashi Fujita Fan Zhang Youngil Koh Su-Yeon Lee Sung-Soo Yoon Eigo Shimizu Mitsuhiro Komura Akihiro Fujimoto Momoko Nagai Mamoru Kato Han Liang Satoru Miyano Zemin Zhang Hidewaki Nakagawa Seiya Imoto
author_sort	Shinichi Mizuno
title	Immunogenomic pan-cancer landscape reveals immune escape mechanisms and immunoediting histories
title_short	Immunogenomic pan-cancer landscape reveals immune escape mechanisms and immunoediting histories
title_full	Immunogenomic pan-cancer landscape reveals immune escape mechanisms and immunoediting histories
title_fullStr	Immunogenomic pan-cancer landscape reveals immune escape mechanisms and immunoediting histories
title_full_unstemmed	Immunogenomic pan-cancer landscape reveals immune escape mechanisms and immunoediting histories
title_sort	immunogenomic pan-cancer landscape reveals immune escape mechanisms and immunoediting histories
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/351129f51da84158b681c55273869ced
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Immunogenomic pan-cancer landscape reveals immune escape mechanisms and immunoediting histories

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