p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival

Cancer cells can produce asparagine, yet both the regulation and biological functions of asparagine are unclear. Here the authors show that p53 suppresses asparagine synthesis and disrupts asparagine-aspartate homeostasis contributing to tumor growth inhibition, and that asparagine and aspartate mod...

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Autores principales:	Longfei Deng, Pengbo Yao, Le Li, Fansen Ji, Shuang Zhao, Chang Xu, Xun Lan, Peng Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/35114a7de3be4c06ae8f90c18be3707c
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spelling	oai:doaj.org-article:35114a7de3be4c06ae8f90c18be3707c2021-12-02T17:31:41Zp53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival10.1038/s41467-020-15573-62041-1723https://doaj.org/article/35114a7de3be4c06ae8f90c18be3707c2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15573-6https://doaj.org/toc/2041-1723Cancer cells can produce asparagine, yet both the regulation and biological functions of asparagine are unclear. Here the authors show that p53 suppresses asparagine synthesis and disrupts asparagine-aspartate homeostasis contributing to tumor growth inhibition, and that asparagine and aspartate modulates AMPK-mediated p53 activation by physically binding to and regulating LKB1.Longfei DengPengbo YaoLe LiFansen JiShuang ZhaoChang XuXun LanPeng JiangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Longfei Deng Pengbo Yao Le Li Fansen Ji Shuang Zhao Chang Xu Xun Lan Peng Jiang p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival
description	Cancer cells can produce asparagine, yet both the regulation and biological functions of asparagine are unclear. Here the authors show that p53 suppresses asparagine synthesis and disrupts asparagine-aspartate homeostasis contributing to tumor growth inhibition, and that asparagine and aspartate modulates AMPK-mediated p53 activation by physically binding to and regulating LKB1.
format	article
author	Longfei Deng Pengbo Yao Le Li Fansen Ji Shuang Zhao Chang Xu Xun Lan Peng Jiang
author_facet	Longfei Deng Pengbo Yao Le Li Fansen Ji Shuang Zhao Chang Xu Xun Lan Peng Jiang
author_sort	Longfei Deng
title	p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival
title_short	p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival
title_full	p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival
title_fullStr	p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival
title_full_unstemmed	p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival
title_sort	p53-mediated control of aspartate-asparagine homeostasis dictates lkb1 activity and modulates cell survival
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/35114a7de3be4c06ae8f90c18be3707c
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p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival

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