Review of recombinant human deoxyribonuclease (rhDNase) in the management of patients with cystic fibrosis

Tacjana PresslerCF Centre, Dept. of Pediatrics, Rigshospitalet, University of Copenhagen DenmarkAbstract: The most important problem in cystic fibrosis (CF) lung disease is chronic airway inflammation and infection, which starts early in life. To prevent severe lung damage, it is important to mobili...

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Autor principal:	Tacjana Pressler
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3515fe47c54941b7afda8adc2bc56319
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spelling	oai:doaj.org-article:3515fe47c54941b7afda8adc2bc563192021-12-02T06:19:48ZReview of recombinant human deoxyribonuclease (rhDNase) in the management of patients with cystic fibrosis1177-54751177-5491https://doaj.org/article/3515fe47c54941b7afda8adc2bc563192008-09-01T00:00:00Zhttp://www.dovepress.com/review-of-recombinant-human-deoxyribonuclease-rhdnase-in-the-managemen-a2316https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Tacjana PresslerCF Centre, Dept. of Pediatrics, Rigshospitalet, University of Copenhagen DenmarkAbstract: The most important problem in cystic fibrosis (CF) lung disease is chronic airway inflammation and infection, which starts early in life. To prevent severe lung damage, it is important to mobilize as much sputum as possible from the lung on a daily basis. RhDNase is an enzyme that breaks down DNA strands in airway secretions, hydrolyzes the DNA present in sputum/mucus of CF patients, reducing viscosity in the lungs and promoting secretion clearance. Several well performed trials have proven its efficacy in young CF patients with mild disease as well as in older patients with more advanced lung disease. Daily inhalation of this agent slows down lung function decline and decreases the frequency of respiratory exacerbations. The drug is well tolerated by most patients independent of the severity of lung disease.Keywords: cystic fibrosis, lung disease, recombinant human deoxyribonuclease Tacjana PresslerDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2008, Iss Issue 4, Pp 611-617 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Tacjana Pressler Review of recombinant human deoxyribonuclease (rhDNase) in the management of patients with cystic fibrosis
description	Tacjana PresslerCF Centre, Dept. of Pediatrics, Rigshospitalet, University of Copenhagen DenmarkAbstract: The most important problem in cystic fibrosis (CF) lung disease is chronic airway inflammation and infection, which starts early in life. To prevent severe lung damage, it is important to mobilize as much sputum as possible from the lung on a daily basis. RhDNase is an enzyme that breaks down DNA strands in airway secretions, hydrolyzes the DNA present in sputum/mucus of CF patients, reducing viscosity in the lungs and promoting secretion clearance. Several well performed trials have proven its efficacy in young CF patients with mild disease as well as in older patients with more advanced lung disease. Daily inhalation of this agent slows down lung function decline and decreases the frequency of respiratory exacerbations. The drug is well tolerated by most patients independent of the severity of lung disease.Keywords: cystic fibrosis, lung disease, recombinant human deoxyribonuclease
format	article
author	Tacjana Pressler
author_facet	Tacjana Pressler
author_sort	Tacjana Pressler
title	Review of recombinant human deoxyribonuclease (rhDNase) in the management of patients with cystic fibrosis
title_short	Review of recombinant human deoxyribonuclease (rhDNase) in the management of patients with cystic fibrosis
title_full	Review of recombinant human deoxyribonuclease (rhDNase) in the management of patients with cystic fibrosis
title_fullStr	Review of recombinant human deoxyribonuclease (rhDNase) in the management of patients with cystic fibrosis
title_full_unstemmed	Review of recombinant human deoxyribonuclease (rhDNase) in the management of patients with cystic fibrosis
title_sort	review of recombinant human deoxyribonuclease (rhdnase) in the management of patients with cystic fibrosis
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/3515fe47c54941b7afda8adc2bc56319
work_keys_str_mv	AT tacjanapressler reviewofrecombinanthumandeoxyribonucleaserhdnaseinthemanagementofpatientswithcysticfibrosis
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Review of recombinant human deoxyribonuclease (rhDNase) in the management of patients with cystic fibrosis

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