Engineering of Long-Term Stable Transparent Nanoemulsion Using High-Gravity Rotating Packed Bed for Oral Drug Delivery

Hao-Ran Wu,1 Chuan-Qi Wang,1 Jie-Xin Wang,1,2 Jian-Feng Chen,1,2 Yuan Le1,2 1State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, People’s Republic of China; 2Research Center of the Ministry of Education for High Gravity Engineeri...

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Autores principales:	Wu HR, Wang CQ, Wang JX, Chen JF, Le Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	nanoemulsion high-gravity rotating packed bed rosuvastatin calcium silybinin stability in vitro dissolution caco-2 permeability. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/351807642c5d4f6da8368f5b33012817
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spelling	oai:doaj.org-article:351807642c5d4f6da8368f5b330128172021-12-02T09:56:20ZEngineering of Long-Term Stable Transparent Nanoemulsion Using High-Gravity Rotating Packed Bed for Oral Drug Delivery1178-2013https://doaj.org/article/351807642c5d4f6da8368f5b330128172020-04-01T00:00:00Zhttps://www.dovepress.com/engineering-of-long-term-stable-transparent-nanoemulsion-using-high-gr-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Hao-Ran Wu,1 Chuan-Qi Wang,1 Jie-Xin Wang,1,2 Jian-Feng Chen,1,2 Yuan Le1,2 1State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, People’s Republic of China; 2Research Center of the Ministry of Education for High Gravity Engineering and Technology, Beijing University of Chemical Technology, Beijing 100029, People’s Republic of ChinaCorrespondence: Yuan LeState Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing, Chaoyang District 100029, People’s Republic of ChinaEmail leyuan@mail.buct.edu.cnBackground: Oil-in-water drug nanoemulsion forms drug delivery systems with high oral bioavailability. The conventional fabrication methods of nanoemulsion are low energy emulsification methods and high energy emulsification methods. However, both two methods are not ideal for industrial production. The problem of low energy emulsification methods is the high dosage of surfactant and co-surfactant which has potential biosecurity issues. What is more, high energy emulsification methods have some disadvantages, like the destruction of drug components, the price of equipment and the difficulties of industrial production. Hence, there have been a few commercial drug nanoemulsions so far.Methods: In this work, we reported a novel method for the fabrication of stable and transparent drug nanoemulsion which contains hydrophilic drug rosuvastatin (ROS) calcium or hydrophobic drug silybinin (SYN) by using high-gravity rotating packed bed (RPB). The drug nanoemulsion was systematically characterized by droplet size, size distribution, stability and in vitro drug release as well as Caco-2 cells permeability.Results: Compared with the self-emulsification method (SE), high-gravity technology could reduce 75% amount of mixed surfactants. The as-prepared nanoemulsion exhibited a very narrow droplet size distribution with a size of 13.53 ±  0.53 nm and a polydispersity index of 0.073 ±  0.018. Meanwhile, the drug nanoemulsion was physicochemically stable at 25°C and 4°C for one-year storage. Furthermore, both ROS and SYN nanoemulsion displayed higher cell permeability and in vitro dissolution than that of commercial formulations.Conclusion: These results demonstrate that RPB can be a potential device to facilitate the industrial production of drug nanoemulsion.Keywords: nanoemulsion, high-gravity rotating packed bed, Rosuvastatin calcium, Silybinin, stability, in vitro dissolution, Caco-2 permeabilityWu HRWang CQWang JXChen JFLe YDove Medical Pressarticlenanoemulsionhigh-gravity rotating packed bedrosuvastatin calciumsilybininstabilityin vitro dissolutioncaco-2 permeability.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 2391-2402 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanoemulsion high-gravity rotating packed bed rosuvastatin calcium silybinin stability in vitro dissolution caco-2 permeability. Medicine (General) R5-920
spellingShingle	nanoemulsion high-gravity rotating packed bed rosuvastatin calcium silybinin stability in vitro dissolution caco-2 permeability. Medicine (General) R5-920 Wu HR Wang CQ Wang JX Chen JF Le Y Engineering of Long-Term Stable Transparent Nanoemulsion Using High-Gravity Rotating Packed Bed for Oral Drug Delivery
description	Hao-Ran Wu,1 Chuan-Qi Wang,1 Jie-Xin Wang,1,2 Jian-Feng Chen,1,2 Yuan Le1,2 1State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, People’s Republic of China; 2Research Center of the Ministry of Education for High Gravity Engineering and Technology, Beijing University of Chemical Technology, Beijing 100029, People’s Republic of ChinaCorrespondence: Yuan LeState Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing, Chaoyang District 100029, People’s Republic of ChinaEmail leyuan@mail.buct.edu.cnBackground: Oil-in-water drug nanoemulsion forms drug delivery systems with high oral bioavailability. The conventional fabrication methods of nanoemulsion are low energy emulsification methods and high energy emulsification methods. However, both two methods are not ideal for industrial production. The problem of low energy emulsification methods is the high dosage of surfactant and co-surfactant which has potential biosecurity issues. What is more, high energy emulsification methods have some disadvantages, like the destruction of drug components, the price of equipment and the difficulties of industrial production. Hence, there have been a few commercial drug nanoemulsions so far.Methods: In this work, we reported a novel method for the fabrication of stable and transparent drug nanoemulsion which contains hydrophilic drug rosuvastatin (ROS) calcium or hydrophobic drug silybinin (SYN) by using high-gravity rotating packed bed (RPB). The drug nanoemulsion was systematically characterized by droplet size, size distribution, stability and in vitro drug release as well as Caco-2 cells permeability.Results: Compared with the self-emulsification method (SE), high-gravity technology could reduce 75% amount of mixed surfactants. The as-prepared nanoemulsion exhibited a very narrow droplet size distribution with a size of 13.53 ±  0.53 nm and a polydispersity index of 0.073 ±  0.018. Meanwhile, the drug nanoemulsion was physicochemically stable at 25°C and 4°C for one-year storage. Furthermore, both ROS and SYN nanoemulsion displayed higher cell permeability and in vitro dissolution than that of commercial formulations.Conclusion: These results demonstrate that RPB can be a potential device to facilitate the industrial production of drug nanoemulsion.Keywords: nanoemulsion, high-gravity rotating packed bed, Rosuvastatin calcium, Silybinin, stability, in vitro dissolution, Caco-2 permeability
format	article
author	Wu HR Wang CQ Wang JX Chen JF Le Y
author_facet	Wu HR Wang CQ Wang JX Chen JF Le Y
author_sort	Wu HR
title	Engineering of Long-Term Stable Transparent Nanoemulsion Using High-Gravity Rotating Packed Bed for Oral Drug Delivery
title_short	Engineering of Long-Term Stable Transparent Nanoemulsion Using High-Gravity Rotating Packed Bed for Oral Drug Delivery
title_full	Engineering of Long-Term Stable Transparent Nanoemulsion Using High-Gravity Rotating Packed Bed for Oral Drug Delivery
title_fullStr	Engineering of Long-Term Stable Transparent Nanoemulsion Using High-Gravity Rotating Packed Bed for Oral Drug Delivery
title_full_unstemmed	Engineering of Long-Term Stable Transparent Nanoemulsion Using High-Gravity Rotating Packed Bed for Oral Drug Delivery
title_sort	engineering of long-term stable transparent nanoemulsion using high-gravity rotating packed bed for oral drug delivery
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/351807642c5d4f6da8368f5b33012817
work_keys_str_mv	AT wuhr engineeringoflongtermstabletransparentnanoemulsionusinghighgravityrotatingpackedbedfororaldrugdelivery AT wangcq engineeringoflongtermstabletransparentnanoemulsionusinghighgravityrotatingpackedbedfororaldrugdelivery AT wangjx engineeringoflongtermstabletransparentnanoemulsionusinghighgravityrotatingpackedbedfororaldrugdelivery AT chenjf engineeringoflongtermstabletransparentnanoemulsionusinghighgravityrotatingpackedbedfororaldrugdelivery AT ley engineeringoflongtermstabletransparentnanoemulsionusinghighgravityrotatingpackedbedfororaldrugdelivery
_version_	1718397875971424256

Engineering of Long-Term Stable Transparent Nanoemulsion Using High-Gravity Rotating Packed Bed for Oral Drug Delivery

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