A parthenogenetic quasi-program causes teratoma-like tumors during aging in wild-type C. elegans

Aging: Runaway programs are a cause of aging The main cause of disease worldwide is aging, a process long suspected to result from damage accumulation. However, new work from a team led by David Gems at University College London describes a different type of cause: quasi-programs, or the futile run-...

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Autores principales:	Hongyuan Wang, Yuan Zhao, Marina Ezcurra, Alexandre Benedetto, Ann F. Gilliat, Josephine Hellberg, Ziyu Ren, Evgeniy R. Galimov, Trin Athigapanich, Johannes Girstmair, Maximilian J. Telford, Colin T. Dolphin, Zhizhou Zhang, David Gems
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/3519f894f35745668a4fd12ca37efb50
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spelling	oai:doaj.org-article:3519f894f35745668a4fd12ca37efb502021-12-02T13:41:46ZA parthenogenetic quasi-program causes teratoma-like tumors during aging in wild-type C. elegans10.1038/s41514-018-0025-32056-3973https://doaj.org/article/3519f894f35745668a4fd12ca37efb502018-06-01T00:00:00Zhttps://doi.org/10.1038/s41514-018-0025-3https://doaj.org/toc/2056-3973Aging: Runaway programs are a cause of aging The main cause of disease worldwide is aging, a process long suspected to result from damage accumulation. However, new work from a team led by David Gems at University College London describes a different type of cause: quasi-programs, or the futile run-on biological programs in later life, supporting a recently proposed, alternative theory about aging. The study focuses on the short-lived worm C. elegans, which during aging develop very large tumors in the uterus. The authors show how such tumors develop due to futile attempts by unfertilized eggs to develop by switching on programs of embryogenesis. In mammals, similar runaway programs cause teratomas, a type of benign tumor of grotesque appearance. This work provides new insights about the nature of aging as a disease process, suggesting that it is to an extent teratoma-like.Hongyuan WangYuan ZhaoMarina EzcurraAlexandre BenedettoAnn F. GilliatJosephine HellbergZiyu RenEvgeniy R. GalimovTrin AthigapanichJohannes GirstmairMaximilian J. TelfordColin T. DolphinZhizhou ZhangDavid GemsNature PortfolioarticleGeriatricsRC952-954.6ENnpj Aging and Mechanisms of Disease, Vol 4, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Hongyuan Wang Yuan Zhao Marina Ezcurra Alexandre Benedetto Ann F. Gilliat Josephine Hellberg Ziyu Ren Evgeniy R. Galimov Trin Athigapanich Johannes Girstmair Maximilian J. Telford Colin T. Dolphin Zhizhou Zhang David Gems A parthenogenetic quasi-program causes teratoma-like tumors during aging in wild-type C. elegans
description	Aging: Runaway programs are a cause of aging The main cause of disease worldwide is aging, a process long suspected to result from damage accumulation. However, new work from a team led by David Gems at University College London describes a different type of cause: quasi-programs, or the futile run-on biological programs in later life, supporting a recently proposed, alternative theory about aging. The study focuses on the short-lived worm C. elegans, which during aging develop very large tumors in the uterus. The authors show how such tumors develop due to futile attempts by unfertilized eggs to develop by switching on programs of embryogenesis. In mammals, similar runaway programs cause teratomas, a type of benign tumor of grotesque appearance. This work provides new insights about the nature of aging as a disease process, suggesting that it is to an extent teratoma-like.
format	article
author	Hongyuan Wang Yuan Zhao Marina Ezcurra Alexandre Benedetto Ann F. Gilliat Josephine Hellberg Ziyu Ren Evgeniy R. Galimov Trin Athigapanich Johannes Girstmair Maximilian J. Telford Colin T. Dolphin Zhizhou Zhang David Gems
author_facet	Hongyuan Wang Yuan Zhao Marina Ezcurra Alexandre Benedetto Ann F. Gilliat Josephine Hellberg Ziyu Ren Evgeniy R. Galimov Trin Athigapanich Johannes Girstmair Maximilian J. Telford Colin T. Dolphin Zhizhou Zhang David Gems
author_sort	Hongyuan Wang
title	A parthenogenetic quasi-program causes teratoma-like tumors during aging in wild-type C. elegans
title_short	A parthenogenetic quasi-program causes teratoma-like tumors during aging in wild-type C. elegans
title_full	A parthenogenetic quasi-program causes teratoma-like tumors during aging in wild-type C. elegans
title_fullStr	A parthenogenetic quasi-program causes teratoma-like tumors during aging in wild-type C. elegans
title_full_unstemmed	A parthenogenetic quasi-program causes teratoma-like tumors during aging in wild-type C. elegans
title_sort	parthenogenetic quasi-program causes teratoma-like tumors during aging in wild-type c. elegans
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3519f894f35745668a4fd12ca37efb50
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A parthenogenetic quasi-program causes teratoma-like tumors during aging in wild-type C. elegans

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