COVID-19-positive cancer patients undergoing active anticancer treatment: An analysis of clinical features and outcomes

Background: Cancer patients, particularly those on active anticancer treatment, are reportedly at a high risk of severe coronavirus disease 2019 (COVID-19) infection and death. This study aimed to describe the clinical characteristics and outcomes of patients diagnosed with COVID-19 whilst on antica...

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Autores principales:	Jamshed Ali, Kashif Sajjad, Amer Rehman Farooqi, Muhammad Tahir Aziz, Ayesha Rahat, Sarah Khan
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Cancer COVID-19 Outcome Pakistan Diseases of the blood and blood-forming organs RC633-647.5 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/351d28f0495e497f901a03604c85b4fe
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spelling	oai:doaj.org-article:351d28f0495e497f901a03604c85b4fe2021-12-02T05:00:01ZCOVID-19-positive cancer patients undergoing active anticancer treatment: An analysis of clinical features and outcomes1658-387610.1016/j.hemonc.2020.12.001https://doaj.org/article/351d28f0495e497f901a03604c85b4fe2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1658387620301801https://doaj.org/toc/1658-3876Background: Cancer patients, particularly those on active anticancer treatment, are reportedly at a high risk of severe coronavirus disease 2019 (COVID-19) infection and death. This study aimed to describe the clinical characteristics and outcomes of patients diagnosed with COVID-19 whilst on anticancer treatment in a developing country. Methods: This is a retrospective observational study of all adult cancer patients at Shaukat Khanum Memorial Cancer Hospital and Research Centre, Pakistan, from March 15, 2020 to July 10, 2020, diagnosed with COVID-19 within 4 weeks of receiving anticancer treatment, where a purposive sampling was performed. Cancer patients who did not receive anticancer treatment and clinical or radiological diagnosis of COVID-19 without a positive reverse transcription–polymerase chain reaction (RT-PCR) test were excluded. The primary endpoint was all-cause mortality after 30 days of COVID-19 test. Data was analyzed with SPSS version 23 (SPSS Inc., Chicago, IL, USA). Categorical parameters were computed using chi-square test, keeping p value < 0.05 as significant. Results: A total of 201 cancer patients with COVID-19 were analyzed. The median age of patients was 45 (18–78) years. Mild symptoms were present in 162 (80.6%) patients, whereas severe symptoms were present in 39 (19.4%) patients. The risk of death was statistically significant (p < .05) amongst patients with age greater than 50 years, metastatic disease, and ongoing palliative anticancer treatment. Anticancer treatment (chemotherapy, radiotherapy, hormonal therapy, targeted therapy, and surgery) received within preceding 4 weeks had no statistically significant (p > .05) impact on mortality. Conclusions: In cancer patients with COVID-19, mortality appears to be principally driven by age, advanced stage of the disease, and palliative intent of cancer treatment. We did not identify evidence that cancer patients on chemotherapy are at significant risk of mortality from COVID-19 correlating to those not on chemotherapy.Jamshed AliKashif SajjadAmer Rehman FarooqiMuhammad Tahir AzizAyesha RahatSarah KhanElsevierarticleCancerCOVID-19OutcomePakistanDiseases of the blood and blood-forming organsRC633-647.5Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENHematology/Oncology and Stem Cell Therapy, Vol 14, Iss 4, Pp 311-317 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cancer COVID-19 Outcome Pakistan Diseases of the blood and blood-forming organs RC633-647.5 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Cancer COVID-19 Outcome Pakistan Diseases of the blood and blood-forming organs RC633-647.5 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Jamshed Ali Kashif Sajjad Amer Rehman Farooqi Muhammad Tahir Aziz Ayesha Rahat Sarah Khan COVID-19-positive cancer patients undergoing active anticancer treatment: An analysis of clinical features and outcomes
description	Background: Cancer patients, particularly those on active anticancer treatment, are reportedly at a high risk of severe coronavirus disease 2019 (COVID-19) infection and death. This study aimed to describe the clinical characteristics and outcomes of patients diagnosed with COVID-19 whilst on anticancer treatment in a developing country. Methods: This is a retrospective observational study of all adult cancer patients at Shaukat Khanum Memorial Cancer Hospital and Research Centre, Pakistan, from March 15, 2020 to July 10, 2020, diagnosed with COVID-19 within 4 weeks of receiving anticancer treatment, where a purposive sampling was performed. Cancer patients who did not receive anticancer treatment and clinical or radiological diagnosis of COVID-19 without a positive reverse transcription–polymerase chain reaction (RT-PCR) test were excluded. The primary endpoint was all-cause mortality after 30 days of COVID-19 test. Data was analyzed with SPSS version 23 (SPSS Inc., Chicago, IL, USA). Categorical parameters were computed using chi-square test, keeping p value < 0.05 as significant. Results: A total of 201 cancer patients with COVID-19 were analyzed. The median age of patients was 45 (18–78) years. Mild symptoms were present in 162 (80.6%) patients, whereas severe symptoms were present in 39 (19.4%) patients. The risk of death was statistically significant (p < .05) amongst patients with age greater than 50 years, metastatic disease, and ongoing palliative anticancer treatment. Anticancer treatment (chemotherapy, radiotherapy, hormonal therapy, targeted therapy, and surgery) received within preceding 4 weeks had no statistically significant (p > .05) impact on mortality. Conclusions: In cancer patients with COVID-19, mortality appears to be principally driven by age, advanced stage of the disease, and palliative intent of cancer treatment. We did not identify evidence that cancer patients on chemotherapy are at significant risk of mortality from COVID-19 correlating to those not on chemotherapy.
format	article
author	Jamshed Ali Kashif Sajjad Amer Rehman Farooqi Muhammad Tahir Aziz Ayesha Rahat Sarah Khan
author_facet	Jamshed Ali Kashif Sajjad Amer Rehman Farooqi Muhammad Tahir Aziz Ayesha Rahat Sarah Khan
author_sort	Jamshed Ali
title	COVID-19-positive cancer patients undergoing active anticancer treatment: An analysis of clinical features and outcomes
title_short	COVID-19-positive cancer patients undergoing active anticancer treatment: An analysis of clinical features and outcomes
title_full	COVID-19-positive cancer patients undergoing active anticancer treatment: An analysis of clinical features and outcomes
title_fullStr	COVID-19-positive cancer patients undergoing active anticancer treatment: An analysis of clinical features and outcomes
title_full_unstemmed	COVID-19-positive cancer patients undergoing active anticancer treatment: An analysis of clinical features and outcomes
title_sort	covid-19-positive cancer patients undergoing active anticancer treatment: an analysis of clinical features and outcomes
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/351d28f0495e497f901a03604c85b4fe
work_keys_str_mv	AT jamshedali covid19positivecancerpatientsundergoingactiveanticancertreatmentananalysisofclinicalfeaturesandoutcomes AT kashifsajjad covid19positivecancerpatientsundergoingactiveanticancertreatmentananalysisofclinicalfeaturesandoutcomes AT amerrehmanfarooqi covid19positivecancerpatientsundergoingactiveanticancertreatmentananalysisofclinicalfeaturesandoutcomes AT muhammadtahiraziz covid19positivecancerpatientsundergoingactiveanticancertreatmentananalysisofclinicalfeaturesandoutcomes AT ayesharahat covid19positivecancerpatientsundergoingactiveanticancertreatmentananalysisofclinicalfeaturesandoutcomes AT sarahkhan covid19positivecancerpatientsundergoingactiveanticancertreatmentananalysisofclinicalfeaturesandoutcomes
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COVID-19-positive cancer patients undergoing active anticancer treatment: An analysis of clinical features and outcomes

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