Genome-wide analysis of miRNA signature in the APPswe/PS1ΔE9 mouse model of alzheimer's disease.

Alzheimer's disease (AD) is the most common cause of dementia. One of the pathological hallmarks of AD is amyloid β (Aβ) deposition. MicroRNAs (miRNAs) are small non-coding RNAs whose expression levels change significantly during neuronal pathogenesis and may be used as diagnostic markers. Some...

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Autores principales:	Hongxue Luo, Qi Wu, Xiaoyang Ye, Yi Xiong, Jinyong Zhu, Junyu Xu, Yarui Diao, Duo Zhang, Maosheng Wang, Jinhua Qiu, Jianting Miao, Wei Zhang, Jun Wan
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3523f9fe483347cd86dc8b803699c5db
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spelling	oai:doaj.org-article:3523f9fe483347cd86dc8b803699c5db2021-11-25T06:03:33ZGenome-wide analysis of miRNA signature in the APPswe/PS1ΔE9 mouse model of alzheimer's disease.1932-620310.1371/journal.pone.0101725https://doaj.org/article/3523f9fe483347cd86dc8b803699c5db2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25148207/?tool=EBIhttps://doaj.org/toc/1932-6203Alzheimer's disease (AD) is the most common cause of dementia. One of the pathological hallmarks of AD is amyloid β (Aβ) deposition. MicroRNAs (miRNAs) are small non-coding RNAs whose expression levels change significantly during neuronal pathogenesis and may be used as diagnostic markers. Some miRNAs are important in AD development by targeting genes responsible for Aβ metabolism. However, a systematic assessment of the miRNA expression profile induced by Aβ-mediated neuronal pathogenesis is still lacking. In the present study, we examined miRNA expression profile by using the APPswe/PS1ΔE9 mouse model of AD. Two sibling pairs of mice were examined, showing 30 and 24 miRNAs with significantly altered expression levels from each paired control, respectively. Nine known miRNAs were common in both groups. Prediction of putative target genes and functional annotation implied that these altered miRNAs affect many target genes mainly involved in PI3K/Akt signaling pathway. This study provides a general profile of miRNAs regulated by Aβ-associated signal pathways, which is helpful to understand the mechanism of Aβ-induced neuronal dysfunction in AD development.Hongxue LuoQi WuXiaoyang YeYi XiongJinyong ZhuJunyu XuYarui DiaoDuo ZhangMaosheng WangJinhua QiuJianting MiaoWei ZhangJun WanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e101725 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hongxue Luo Qi Wu Xiaoyang Ye Yi Xiong Jinyong Zhu Junyu Xu Yarui Diao Duo Zhang Maosheng Wang Jinhua Qiu Jianting Miao Wei Zhang Jun Wan Genome-wide analysis of miRNA signature in the APPswe/PS1ΔE9 mouse model of alzheimer's disease.
description	Alzheimer's disease (AD) is the most common cause of dementia. One of the pathological hallmarks of AD is amyloid β (Aβ) deposition. MicroRNAs (miRNAs) are small non-coding RNAs whose expression levels change significantly during neuronal pathogenesis and may be used as diagnostic markers. Some miRNAs are important in AD development by targeting genes responsible for Aβ metabolism. However, a systematic assessment of the miRNA expression profile induced by Aβ-mediated neuronal pathogenesis is still lacking. In the present study, we examined miRNA expression profile by using the APPswe/PS1ΔE9 mouse model of AD. Two sibling pairs of mice were examined, showing 30 and 24 miRNAs with significantly altered expression levels from each paired control, respectively. Nine known miRNAs were common in both groups. Prediction of putative target genes and functional annotation implied that these altered miRNAs affect many target genes mainly involved in PI3K/Akt signaling pathway. This study provides a general profile of miRNAs regulated by Aβ-associated signal pathways, which is helpful to understand the mechanism of Aβ-induced neuronal dysfunction in AD development.
format	article
author	Hongxue Luo Qi Wu Xiaoyang Ye Yi Xiong Jinyong Zhu Junyu Xu Yarui Diao Duo Zhang Maosheng Wang Jinhua Qiu Jianting Miao Wei Zhang Jun Wan
author_facet	Hongxue Luo Qi Wu Xiaoyang Ye Yi Xiong Jinyong Zhu Junyu Xu Yarui Diao Duo Zhang Maosheng Wang Jinhua Qiu Jianting Miao Wei Zhang Jun Wan
author_sort	Hongxue Luo
title	Genome-wide analysis of miRNA signature in the APPswe/PS1ΔE9 mouse model of alzheimer's disease.
title_short	Genome-wide analysis of miRNA signature in the APPswe/PS1ΔE9 mouse model of alzheimer's disease.
title_full	Genome-wide analysis of miRNA signature in the APPswe/PS1ΔE9 mouse model of alzheimer's disease.
title_fullStr	Genome-wide analysis of miRNA signature in the APPswe/PS1ΔE9 mouse model of alzheimer's disease.
title_full_unstemmed	Genome-wide analysis of miRNA signature in the APPswe/PS1ΔE9 mouse model of alzheimer's disease.
title_sort	genome-wide analysis of mirna signature in the appswe/ps1δe9 mouse model of alzheimer's disease.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/3523f9fe483347cd86dc8b803699c5db
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Genome-wide analysis of miRNA signature in the APPswe/PS1ΔE9 mouse model of alzheimer's disease.

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