Mechanical and structural characterisation of the dural venous sinuses

Abstract The dural venous sinuses play an integral role in draining venous blood from the cranial cavity. As a result of the sinuses anatomical location, they are of significant importance when evaluating the mechanopathology of traumatic brain injury (TBI). Despite the importance of the dural venou...

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Autores principales:	Darragh R. Walsh, James J. Lynch, David T. O’ Connor, David T. Newport, John J. E. Mulvihill
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/352caceee7f8480dae882479d3f9fc32
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spelling	oai:doaj.org-article:352caceee7f8480dae882479d3f9fc322021-12-02T11:43:36ZMechanical and structural characterisation of the dural venous sinuses10.1038/s41598-020-78694-42045-2322https://doaj.org/article/352caceee7f8480dae882479d3f9fc322020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78694-4https://doaj.org/toc/2045-2322Abstract The dural venous sinuses play an integral role in draining venous blood from the cranial cavity. As a result of the sinuses anatomical location, they are of significant importance when evaluating the mechanopathology of traumatic brain injury (TBI). Despite the importance of the dural venous sinuses in normal neurophysiology, no mechanical analyses have been conducted on the tissues. In this study, we conduct mechanical and structural analysis on porcine dural venous sinus tissue to help elucidate the tissues’ function in healthy and diseased conditions. With longitudinal elastic moduli values ranging from 33 to 58 MPa, we demonstrate that the sinuses exhibit higher mechanical stiffness than that of native dural tissue, which may be of interest to the field of TBI modelling. Furthermore, by employing histological staining and a colour deconvolution protocol, we show that the sinuses have a collagen-dominant extracellular matrix, with collagen area fractions ranging from 84 to 94%, which likely explains the tissue’s large mechanical stiffness. In summary, we provide the first investigation of the dural venous sinus mechanical behaviour with accompanying structural analysis, which may aid in understanding TBI mechanopathology.Darragh R. WalshJames J. LynchDavid T. O’ ConnorDavid T. NewportJohn J. E. MulvihillNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Darragh R. Walsh James J. Lynch David T. O’ Connor David T. Newport John J. E. Mulvihill Mechanical and structural characterisation of the dural venous sinuses
description	Abstract The dural venous sinuses play an integral role in draining venous blood from the cranial cavity. As a result of the sinuses anatomical location, they are of significant importance when evaluating the mechanopathology of traumatic brain injury (TBI). Despite the importance of the dural venous sinuses in normal neurophysiology, no mechanical analyses have been conducted on the tissues. In this study, we conduct mechanical and structural analysis on porcine dural venous sinus tissue to help elucidate the tissues’ function in healthy and diseased conditions. With longitudinal elastic moduli values ranging from 33 to 58 MPa, we demonstrate that the sinuses exhibit higher mechanical stiffness than that of native dural tissue, which may be of interest to the field of TBI modelling. Furthermore, by employing histological staining and a colour deconvolution protocol, we show that the sinuses have a collagen-dominant extracellular matrix, with collagen area fractions ranging from 84 to 94%, which likely explains the tissue’s large mechanical stiffness. In summary, we provide the first investigation of the dural venous sinus mechanical behaviour with accompanying structural analysis, which may aid in understanding TBI mechanopathology.
format	article
author	Darragh R. Walsh James J. Lynch David T. O’ Connor David T. Newport John J. E. Mulvihill
author_facet	Darragh R. Walsh James J. Lynch David T. O’ Connor David T. Newport John J. E. Mulvihill
author_sort	Darragh R. Walsh
title	Mechanical and structural characterisation of the dural venous sinuses
title_short	Mechanical and structural characterisation of the dural venous sinuses
title_full	Mechanical and structural characterisation of the dural venous sinuses
title_fullStr	Mechanical and structural characterisation of the dural venous sinuses
title_full_unstemmed	Mechanical and structural characterisation of the dural venous sinuses
title_sort	mechanical and structural characterisation of the dural venous sinuses
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/352caceee7f8480dae882479d3f9fc32
work_keys_str_mv	AT darraghrwalsh mechanicalandstructuralcharacterisationoftheduralvenoussinuses AT jamesjlynch mechanicalandstructuralcharacterisationoftheduralvenoussinuses AT davidtoconnor mechanicalandstructuralcharacterisationoftheduralvenoussinuses AT davidtnewport mechanicalandstructuralcharacterisationoftheduralvenoussinuses AT johnjemulvihill mechanicalandstructuralcharacterisationoftheduralvenoussinuses
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Mechanical and structural characterisation of the dural venous sinuses

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