Posterior cingulate cross-hemispheric functional connectivity predicts the level of consciousness in traumatic brain injury

Abstract Previous studies have demonstrated that altered states of consciousness are related to changes in resting state activity in the default-mode network (DMN). Anatomically, the DMN can be divided into anterior and posterior regions. The anterior DMN includes the perigenual anterior cingulate c...

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Autores principales:	Haosu Zhang, Rui Dai, Pengmin Qin, Weijun Tang, Jin Hu, Xuchu Weng, Xing Wu, Ying Mao, Xuehai Wu, Georg Northoff
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/352ec8f0538043ac96019f89e3a799a1
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spelling	oai:doaj.org-article:352ec8f0538043ac96019f89e3a799a12021-12-02T15:06:06ZPosterior cingulate cross-hemispheric functional connectivity predicts the level of consciousness in traumatic brain injury10.1038/s41598-017-00392-52045-2322https://doaj.org/article/352ec8f0538043ac96019f89e3a799a12017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00392-5https://doaj.org/toc/2045-2322Abstract Previous studies have demonstrated that altered states of consciousness are related to changes in resting state activity in the default-mode network (DMN). Anatomically, the DMN can be divided into anterior and posterior regions. The anterior DMN includes the perigenual anterior cingulate cortex and other medial prefrontal cortical regions, whereas the posterior DMN includes regions such as the posterior cingulate cortex (PCC) and the temporal parietal junction (TPJ). Although differential roles have been attributed to the anterior and posterior DMN regions, their exact contributions to consciousness levels remain unclear. To investigate the specific role of the posterior DMN in consciousness levels, we investigated 20 healthy controls (7 females, mean age = 33.6 years old) and 20 traumatic brain injury (TBI) patients (5 females, mean age = 43 years old) whose brain lesions were mainly restricted to the bilateral frontal cortex but retained a well-preserved posterior DMN (e.g., the PCC and the TPJ) and who exhibited varying levels of consciousness. We investigated the intra- and cross-functional connectivity strengths (FCSs) between the right/left PCC and the right/left TPJ and their correlation with consciousness levels. Significant reductions in both the intra- and cross-hemispheric FCSs were observed in patients compared with controls. A significant correlation with consciousness levels was observed only for the cross-hemispheric PCC-TPJ FCS but not for the intra-hemispheric PCC-TPJ FCS. Taken together, our results show that the cross-hemispheric posterior DMN is related to consciousness levels in a specific group of patients without posterior structural lesions. We therefore propose that the PCC may be central in maintaining consciousness through its cross-hemispheric FC with the TPJ.Haosu ZhangRui DaiPengmin QinWeijun TangJin HuXuchu WengXing WuYing MaoXuehai WuGeorg NorthoffNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Haosu Zhang Rui Dai Pengmin Qin Weijun Tang Jin Hu Xuchu Weng Xing Wu Ying Mao Xuehai Wu Georg Northoff Posterior cingulate cross-hemispheric functional connectivity predicts the level of consciousness in traumatic brain injury
description	Abstract Previous studies have demonstrated that altered states of consciousness are related to changes in resting state activity in the default-mode network (DMN). Anatomically, the DMN can be divided into anterior and posterior regions. The anterior DMN includes the perigenual anterior cingulate cortex and other medial prefrontal cortical regions, whereas the posterior DMN includes regions such as the posterior cingulate cortex (PCC) and the temporal parietal junction (TPJ). Although differential roles have been attributed to the anterior and posterior DMN regions, their exact contributions to consciousness levels remain unclear. To investigate the specific role of the posterior DMN in consciousness levels, we investigated 20 healthy controls (7 females, mean age = 33.6 years old) and 20 traumatic brain injury (TBI) patients (5 females, mean age = 43 years old) whose brain lesions were mainly restricted to the bilateral frontal cortex but retained a well-preserved posterior DMN (e.g., the PCC and the TPJ) and who exhibited varying levels of consciousness. We investigated the intra- and cross-functional connectivity strengths (FCSs) between the right/left PCC and the right/left TPJ and their correlation with consciousness levels. Significant reductions in both the intra- and cross-hemispheric FCSs were observed in patients compared with controls. A significant correlation with consciousness levels was observed only for the cross-hemispheric PCC-TPJ FCS but not for the intra-hemispheric PCC-TPJ FCS. Taken together, our results show that the cross-hemispheric posterior DMN is related to consciousness levels in a specific group of patients without posterior structural lesions. We therefore propose that the PCC may be central in maintaining consciousness through its cross-hemispheric FC with the TPJ.
format	article
author	Haosu Zhang Rui Dai Pengmin Qin Weijun Tang Jin Hu Xuchu Weng Xing Wu Ying Mao Xuehai Wu Georg Northoff
author_facet	Haosu Zhang Rui Dai Pengmin Qin Weijun Tang Jin Hu Xuchu Weng Xing Wu Ying Mao Xuehai Wu Georg Northoff
author_sort	Haosu Zhang
title	Posterior cingulate cross-hemispheric functional connectivity predicts the level of consciousness in traumatic brain injury
title_short	Posterior cingulate cross-hemispheric functional connectivity predicts the level of consciousness in traumatic brain injury
title_full	Posterior cingulate cross-hemispheric functional connectivity predicts the level of consciousness in traumatic brain injury
title_fullStr	Posterior cingulate cross-hemispheric functional connectivity predicts the level of consciousness in traumatic brain injury
title_full_unstemmed	Posterior cingulate cross-hemispheric functional connectivity predicts the level of consciousness in traumatic brain injury
title_sort	posterior cingulate cross-hemispheric functional connectivity predicts the level of consciousness in traumatic brain injury
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/352ec8f0538043ac96019f89e3a799a1
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Posterior cingulate cross-hemispheric functional connectivity predicts the level of consciousness in traumatic brain injury

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