Biomimetic mineralized strontium-doped hydroxyapatite on porous poly(L-lactic acid) scaffolds for bone defect repair

Min Ge,1,2 Kun Ge,1,3 Fei Gao,4 Weixiao Yan,1,2 Huifang Liu,2 Li Xue,1 Yi Jin,1,2 Haiyun Ma,1 Jinchao Zhang1,2 1Department of Chemistry, College of Chemistry and Environmental Science, Hebei University, Baoding, People’s Republic of China; 2Key Laboratory of Chemical Biology of Hebei Prov...

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Autores principales:	Ge M, Ge K, Gao F, Yan W, Liu H, Xue L, Jin Y, Ma H, Zhang J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Sr-HA PLLA porous scaffold osteoinductivity bone repair Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/352f1e5d888d4c508aa412ebec36149a
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spelling	oai:doaj.org-article:352f1e5d888d4c508aa412ebec36149a2021-12-02T05:42:44ZBiomimetic mineralized strontium-doped hydroxyapatite on porous poly(L-lactic acid) scaffolds for bone defect repair1178-2013https://doaj.org/article/352f1e5d888d4c508aa412ebec36149a2018-03-01T00:00:00Zhttps://www.dovepress.com/biomimetic-mineralized-strontium-doped-hydroxyapatite-on-porous-polyl--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Min Ge,1,2 Kun Ge,1,3 Fei Gao,4 Weixiao Yan,1,2 Huifang Liu,2 Li Xue,1 Yi Jin,1,2 Haiyun Ma,1 Jinchao Zhang1,2 1Department of Chemistry, College of Chemistry and Environmental Science, Hebei University, Baoding, People’s Republic of China; 2Key Laboratory of Chemical Biology of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Hebei University, Baoding, People’s Republic of China; 3Department of Science and Technology, Affiliated Hospital of Hebei University, Baoding, People’s Republic of China; 4Department of Orthopedics, Affiliated Hospital of Hebei University, Baoding, People’s Republic of China Introduction: Poly(L-lactic acid) (PLLA) has been approved for clinical use by the US Food and Drug Administration (FDA); however, their stronger hydrophobicity and relatively fast degradation rate restricted their widespread application. In consideration of the composition of bone, the inorganic–organic composite has a great application prospect in bone tissue engineering. Many inorganic–organic composite scaffolds were prepared by directly mixing the active ingredient, but this method is uncontrolled and will lead to lack of homogeneity in the polymer matrix. Strontium (Sr) is an admirable addition to improve the bioactivity and bone induction of hydroxyapatite (HA). To our knowledge, the application of biomimetic mineralized strontium-doped hydroxyapatite on porous poly(L-lactic acid) (Sr-HA/PLLA) scaffolds for bone defect repair has never been reported till date. Biomimetic mineralized Sr-HA/PLLA porous scaffold was developed in this study. The results indicated that the Sr-HA/PLLA porous scaffold could improve the surface hydrophobicity, reduce the acidic environment of the degradation, and enhance the osteoinductivity; moreover, the ability of protein adsorption and the modulus of compression were increased. The results also clearly showed the effectiveness of the Sr-HA/PLLA porous scaffold in promoting cell adhesion, proliferation, and alkaline phosphatase (ALP) activity. The micro computed tomography (micro-CT) results showed that more new bones were formed by Sr-HA/PLLA porous scaffold treatment. The histological results confirmed the osteoinductivity of the Sr-HA/PLLA porous scaffold. The results suggested that the Sr-HA/PLLA porous scaffold has a good application prospect in bone tissue engineering in the future.Purpose: The purpose of this study was to promote the bone repair.Materials and methods: Surgical operation of rabbits was carried out in this study.Results: The results showed that formation of a large number of new bones by the Sr-HA/PLLA porous scaffold treatment is possible.Conclusion: Biomimetic mineralized Sr-HA/PLLA porous scaffold could effectively promote the restoration of bone defects in vivo. Keywords: Sr-HA, PLLA porous scaffold, biomimetic mineralization, bone repairGe MGe KGao FYan WLiu HXue LJin YMa HZhang JDove Medical PressarticleSr-HAPLLA porous scaffoldosteoinductivitybone repairMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 1707-1721 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Sr-HA PLLA porous scaffold osteoinductivity bone repair Medicine (General) R5-920
spellingShingle	Sr-HA PLLA porous scaffold osteoinductivity bone repair Medicine (General) R5-920 Ge M Ge K Gao F Yan W Liu H Xue L Jin Y Ma H Zhang J Biomimetic mineralized strontium-doped hydroxyapatite on porous poly(L-lactic acid) scaffolds for bone defect repair
description	Min Ge,1,2 Kun Ge,1,3 Fei Gao,4 Weixiao Yan,1,2 Huifang Liu,2 Li Xue,1 Yi Jin,1,2 Haiyun Ma,1 Jinchao Zhang1,2 1Department of Chemistry, College of Chemistry and Environmental Science, Hebei University, Baoding, People’s Republic of China; 2Key Laboratory of Chemical Biology of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Hebei University, Baoding, People’s Republic of China; 3Department of Science and Technology, Affiliated Hospital of Hebei University, Baoding, People’s Republic of China; 4Department of Orthopedics, Affiliated Hospital of Hebei University, Baoding, People’s Republic of China Introduction: Poly(L-lactic acid) (PLLA) has been approved for clinical use by the US Food and Drug Administration (FDA); however, their stronger hydrophobicity and relatively fast degradation rate restricted their widespread application. In consideration of the composition of bone, the inorganic–organic composite has a great application prospect in bone tissue engineering. Many inorganic–organic composite scaffolds were prepared by directly mixing the active ingredient, but this method is uncontrolled and will lead to lack of homogeneity in the polymer matrix. Strontium (Sr) is an admirable addition to improve the bioactivity and bone induction of hydroxyapatite (HA). To our knowledge, the application of biomimetic mineralized strontium-doped hydroxyapatite on porous poly(L-lactic acid) (Sr-HA/PLLA) scaffolds for bone defect repair has never been reported till date. Biomimetic mineralized Sr-HA/PLLA porous scaffold was developed in this study. The results indicated that the Sr-HA/PLLA porous scaffold could improve the surface hydrophobicity, reduce the acidic environment of the degradation, and enhance the osteoinductivity; moreover, the ability of protein adsorption and the modulus of compression were increased. The results also clearly showed the effectiveness of the Sr-HA/PLLA porous scaffold in promoting cell adhesion, proliferation, and alkaline phosphatase (ALP) activity. The micro computed tomography (micro-CT) results showed that more new bones were formed by Sr-HA/PLLA porous scaffold treatment. The histological results confirmed the osteoinductivity of the Sr-HA/PLLA porous scaffold. The results suggested that the Sr-HA/PLLA porous scaffold has a good application prospect in bone tissue engineering in the future.Purpose: The purpose of this study was to promote the bone repair.Materials and methods: Surgical operation of rabbits was carried out in this study.Results: The results showed that formation of a large number of new bones by the Sr-HA/PLLA porous scaffold treatment is possible.Conclusion: Biomimetic mineralized Sr-HA/PLLA porous scaffold could effectively promote the restoration of bone defects in vivo. Keywords: Sr-HA, PLLA porous scaffold, biomimetic mineralization, bone repair
format	article
author	Ge M Ge K Gao F Yan W Liu H Xue L Jin Y Ma H Zhang J
author_facet	Ge M Ge K Gao F Yan W Liu H Xue L Jin Y Ma H Zhang J
author_sort	Ge M
title	Biomimetic mineralized strontium-doped hydroxyapatite on porous poly(L-lactic acid) scaffolds for bone defect repair
title_short	Biomimetic mineralized strontium-doped hydroxyapatite on porous poly(L-lactic acid) scaffolds for bone defect repair
title_full	Biomimetic mineralized strontium-doped hydroxyapatite on porous poly(L-lactic acid) scaffolds for bone defect repair
title_fullStr	Biomimetic mineralized strontium-doped hydroxyapatite on porous poly(L-lactic acid) scaffolds for bone defect repair
title_full_unstemmed	Biomimetic mineralized strontium-doped hydroxyapatite on porous poly(L-lactic acid) scaffolds for bone defect repair
title_sort	biomimetic mineralized strontium-doped hydroxyapatite on porous poly(l-lactic acid) scaffolds for bone defect repair
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/352f1e5d888d4c508aa412ebec36149a
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Biomimetic mineralized strontium-doped hydroxyapatite on porous poly(L-lactic acid) scaffolds for bone defect repair

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