$Experimental study of a 3D printed permanent implantable porous Ta-coated bone plate for fracture fixation$
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Experimental study of a 3D printed permanent implantable porous Ta-coated bone plate for fracture fixation

Metal plates have always been the gold standard in the clinic for internal fracture fixation due to their high strength advantages. However, high elastic modulus can cause stress shielding and lead to bone embrittlement. This study used an electron beam melting method to prepare personalized porous...

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Autores principales:	Baoyi Liu, Zhijie Ma, Junlei Li, Hui Xie, Xiaowei Wei, Benjie Wang, Simiao Tian, Jiahui Yang, Lei Yang, Liangliang Cheng, Lu Li, Dewei Zhao
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2022
Materias:	3D printing Porous bone plate Ta coating Osteogenesis Osseointegration Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/352f805f2d8f499490523cf589e62944
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spelling	oai:doaj.org-article:352f805f2d8f499490523cf589e629442021-11-28T04:35:33ZExperimental study of a 3D printed permanent implantable porous Ta-coated bone plate for fracture fixation2452-199X10.1016/j.bioactmat.2021.09.009https://doaj.org/article/352f805f2d8f499490523cf589e629442022-04-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2452199X21004199https://doaj.org/toc/2452-199XMetal plates have always been the gold standard in the clinic for internal fracture fixation due to their high strength advantages. However, high elastic modulus can cause stress shielding and lead to bone embrittlement. This study used an electron beam melting method to prepare personalized porous Ti6Al4V (pTi) bone plates. Then, chemical vapor deposition (CVD) technology coats tantalum (Ta) metal on the pTi bone plates. The prepared porous Ta-coated bone plate has an elastic modulus similar to cortical bone, and no stress shielding occurred. In vitro experiments showed that compared with pTi plates, Ta coating significantly enhances the attachment and proliferation of cells on the surface of the scaffold. To better evaluate the function of the Ta-coated bone plate, animal experiments were conducted using a coat tibia fracture model. Our results showed that the Ta-coated bone plate could effectively fix the fracture. Both imaging and histological analysis showed that the Ta-coated bone plate had prominent indirect binding of callus formation. Histological results showed that new bone grew at the interface and formed good osseointegration with the host bone. Therefore, this study provides an alternative to bio-functional Ta-coated bone plates with improved osseointegration and osteogenic functions for orthopaedic applications.Baoyi LiuZhijie MaJunlei LiHui XieXiaowei WeiBenjie WangSimiao TianJiahui YangLei YangLiangliang ChengLu LiDewei ZhaoKeAi Communications Co., Ltd.article3D printingPorous bone plateTa coatingOsteogenesisOsseointegrationMaterials of engineering and construction. Mechanics of materialsTA401-492Biology (General)QH301-705.5ENBioactive Materials, Vol 10, Iss , Pp 269-280 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	3D printing Porous bone plate Ta coating Osteogenesis Osseointegration Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
spellingShingle	3D printing Porous bone plate Ta coating Osteogenesis Osseointegration Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5 Baoyi Liu Zhijie Ma Junlei Li Hui Xie Xiaowei Wei Benjie Wang Simiao Tian Jiahui Yang Lei Yang Liangliang Cheng Lu Li Dewei Zhao Experimental study of a 3D printed permanent implantable porous Ta-coated bone plate for fracture fixation
description	Metal plates have always been the gold standard in the clinic for internal fracture fixation due to their high strength advantages. However, high elastic modulus can cause stress shielding and lead to bone embrittlement. This study used an electron beam melting method to prepare personalized porous Ti6Al4V (pTi) bone plates. Then, chemical vapor deposition (CVD) technology coats tantalum (Ta) metal on the pTi bone plates. The prepared porous Ta-coated bone plate has an elastic modulus similar to cortical bone, and no stress shielding occurred. In vitro experiments showed that compared with pTi plates, Ta coating significantly enhances the attachment and proliferation of cells on the surface of the scaffold. To better evaluate the function of the Ta-coated bone plate, animal experiments were conducted using a coat tibia fracture model. Our results showed that the Ta-coated bone plate could effectively fix the fracture. Both imaging and histological analysis showed that the Ta-coated bone plate had prominent indirect binding of callus formation. Histological results showed that new bone grew at the interface and formed good osseointegration with the host bone. Therefore, this study provides an alternative to bio-functional Ta-coated bone plates with improved osseointegration and osteogenic functions for orthopaedic applications.
format	article
author	Baoyi Liu Zhijie Ma Junlei Li Hui Xie Xiaowei Wei Benjie Wang Simiao Tian Jiahui Yang Lei Yang Liangliang Cheng Lu Li Dewei Zhao
author_facet	Baoyi Liu Zhijie Ma Junlei Li Hui Xie Xiaowei Wei Benjie Wang Simiao Tian Jiahui Yang Lei Yang Liangliang Cheng Lu Li Dewei Zhao
author_sort	Baoyi Liu
title	Experimental study of a 3D printed permanent implantable porous Ta-coated bone plate for fracture fixation
title_short	Experimental study of a 3D printed permanent implantable porous Ta-coated bone plate for fracture fixation
title_full	Experimental study of a 3D printed permanent implantable porous Ta-coated bone plate for fracture fixation
title_fullStr	Experimental study of a 3D printed permanent implantable porous Ta-coated bone plate for fracture fixation
title_full_unstemmed	Experimental study of a 3D printed permanent implantable porous Ta-coated bone plate for fracture fixation
title_sort	experimental study of a 3d printed permanent implantable porous ta-coated bone plate for fracture fixation
publisher	KeAi Communications Co., Ltd.
publishDate	2022
url	https://doaj.org/article/352f805f2d8f499490523cf589e62944
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Experimental study of a 3D printed permanent implantable porous Ta-coated bone plate for fracture fixation

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