Preparation, in vitro release, and pharmacokinetics in rabbits of lyophilized injection of sorafenib solid lipid nanoparticles

Hong Zhang, Fu-Ming Zhang, Shi-Jun YanDepartment of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, People&rsquo;s Republic of ChinaAbstract: Sorafenib solid lipid nanoparticles (S-SLN) were prepared by emulsion evaporation&ndash;solidification at low temperature. Morphology wa...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zhang H, Zhang FM, Yan SJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/35351c1a4d36428d98c62258074dd651
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:35351c1a4d36428d98c62258074dd651
record_format	dspace
spelling	oai:doaj.org-article:35351c1a4d36428d98c62258074dd6512021-12-02T05:40:41ZPreparation, in vitro release, and pharmacokinetics in rabbits of lyophilized injection of sorafenib solid lipid nanoparticles1176-91141178-2013https://doaj.org/article/35351c1a4d36428d98c62258074dd6512012-06-01T00:00:00Zhttp://www.dovepress.com/preparation-in-vitro-release-and-pharmacokinetics-in-rabbits-of-lyophi-a10136https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Hong Zhang, Fu-Ming Zhang, Shi-Jun YanDepartment of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, People&rsquo;s Republic of ChinaAbstract: Sorafenib solid lipid nanoparticles (S-SLN) were prepared by emulsion evaporation&ndash;solidification at low temperature. Morphology was examined by transmission electron microscope. Particle size and zeta potential were determined by laser granularity equipment. Encapsulation efficiency (EE) was detected by Sephadex gel chromatography and high-performance liquid chromatography (HPLC). The in vitro release profile of S-SLN was studied with dialysis technology. The lyophilized injection of S-SLN was prepared by freeze drying and analyzed by differential scanning calorimetry. The plasma concentration of sorafenib in blood was determined by HPLC. The solid lipid nanoparticles assumed a spherical shape with an even distribution of diameter and particle size 108.23 &plusmn; 7.01 nm (n = 3). The polydispersity index, zeta potential, and EE were determined to be 0.25 &plusmn; 0.02, -16.37 &plusmn; 0.65 mV, and 93.49% &plusmn; 1.87%, respectively (n = 3). The in vitro release accorded with the Weibull distribution model. An equal volume of 15% (w/v) mannitol performed better as the protective agent for a lyophilized injection of S-SLN with a new material phase formation. The pharmacokinetic processes of sorafenib solution and lyophilized injection of S-SLN in vivo were in accordance with the two-compartment and one-compartment models, respectively. S-SLN nanoparticles are thus considered a promising drug-delivery system.Keywords: sorafenib, solid lipid nanoparticles, material phase analysis, HPLC, release profile, pharmacokineticsZhang HZhang FMYan SJDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 2901-2910 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Zhang H Zhang FM Yan SJ Preparation, in vitro release, and pharmacokinetics in rabbits of lyophilized injection of sorafenib solid lipid nanoparticles
description	Hong Zhang, Fu-Ming Zhang, Shi-Jun YanDepartment of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, People&rsquo;s Republic of ChinaAbstract: Sorafenib solid lipid nanoparticles (S-SLN) were prepared by emulsion evaporation&ndash;solidification at low temperature. Morphology was examined by transmission electron microscope. Particle size and zeta potential were determined by laser granularity equipment. Encapsulation efficiency (EE) was detected by Sephadex gel chromatography and high-performance liquid chromatography (HPLC). The in vitro release profile of S-SLN was studied with dialysis technology. The lyophilized injection of S-SLN was prepared by freeze drying and analyzed by differential scanning calorimetry. The plasma concentration of sorafenib in blood was determined by HPLC. The solid lipid nanoparticles assumed a spherical shape with an even distribution of diameter and particle size 108.23 &plusmn; 7.01 nm (n = 3). The polydispersity index, zeta potential, and EE were determined to be 0.25 &plusmn; 0.02, -16.37 &plusmn; 0.65 mV, and 93.49% &plusmn; 1.87%, respectively (n = 3). The in vitro release accorded with the Weibull distribution model. An equal volume of 15% (w/v) mannitol performed better as the protective agent for a lyophilized injection of S-SLN with a new material phase formation. The pharmacokinetic processes of sorafenib solution and lyophilized injection of S-SLN in vivo were in accordance with the two-compartment and one-compartment models, respectively. S-SLN nanoparticles are thus considered a promising drug-delivery system.Keywords: sorafenib, solid lipid nanoparticles, material phase analysis, HPLC, release profile, pharmacokinetics
format	article
author	Zhang H Zhang FM Yan SJ
author_facet	Zhang H Zhang FM Yan SJ
author_sort	Zhang H
title	Preparation, in vitro release, and pharmacokinetics in rabbits of lyophilized injection of sorafenib solid lipid nanoparticles
title_short	Preparation, in vitro release, and pharmacokinetics in rabbits of lyophilized injection of sorafenib solid lipid nanoparticles
title_full	Preparation, in vitro release, and pharmacokinetics in rabbits of lyophilized injection of sorafenib solid lipid nanoparticles
title_fullStr	Preparation, in vitro release, and pharmacokinetics in rabbits of lyophilized injection of sorafenib solid lipid nanoparticles
title_full_unstemmed	Preparation, in vitro release, and pharmacokinetics in rabbits of lyophilized injection of sorafenib solid lipid nanoparticles
title_sort	preparation, in vitro release, and pharmacokinetics in rabbits of lyophilized injection of sorafenib solid lipid nanoparticles
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/35351c1a4d36428d98c62258074dd651
work_keys_str_mv	AT zhangh preparationinvitroreleaseandpharmacokineticsinrabbitsoflyophilizedinjectionofsorafenibsolidlipidnanoparticles AT zhangfm preparationinvitroreleaseandpharmacokineticsinrabbitsoflyophilizedinjectionofsorafenibsolidlipidnanoparticles AT yansj preparationinvitroreleaseandpharmacokineticsinrabbitsoflyophilizedinjectionofsorafenibsolidlipidnanoparticles
_version_	1718400288192200704

Preparation, in vitro release, and pharmacokinetics in rabbits of lyophilized injection of sorafenib solid lipid nanoparticles

Ejemplares similares