Fungicidal activity of peptides encoded by immunoglobulin genes

Abstract Evidence from previous works disclosed the antimicrobial, antiviral, anti-tumour and/or immunomodulatory activity exerted, through different mechanisms of action, by peptides expressed in the complementarity-determining regions or even in the constant region of antibodies, independently fro...

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Autores principales:	Luciano Polonelli, Tecla Ciociola, Martina Sperindè, Laura Giovati, Tiziana D’Adda, Serena Galati, Luiz R. Travassos, Walter Magliani, Stefania Conti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/353538c1f54249c5af512a70da48e7df
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spelling	oai:doaj.org-article:353538c1f54249c5af512a70da48e7df2021-12-02T15:05:51ZFungicidal activity of peptides encoded by immunoglobulin genes10.1038/s41598-017-11396-62045-2322https://doaj.org/article/353538c1f54249c5af512a70da48e7df2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-11396-6https://doaj.org/toc/2045-2322Abstract Evidence from previous works disclosed the antimicrobial, antiviral, anti-tumour and/or immunomodulatory activity exerted, through different mechanisms of action, by peptides expressed in the complementarity-determining regions or even in the constant region of antibodies, independently from their specificity and isotype. Presently, we report the selection, from available databases, of peptide sequences encoded by immunoglobulin genes for the evaluation of their potential biological activities. Synthetic peptides representing the translated products of J lambda and J heavy genes proved to act in vitro against pathogenic fungi, entering yeast cells and causing their death, and exerted a therapeutic effect in a Galleria mellonella model of infection by Candida albicans. No haemolytic, cytotoxic and genotoxic effects were observed on mammalian cells. These findings raise the hypothesis that antibodies could be the evolutionary result of the adaptive combination of gene products ancestrally devoted to innate antimicrobial immunity.Luciano PolonelliTecla CiociolaMartina SperindèLaura GiovatiTiziana D’AddaSerena GalatiLuiz R. TravassosWalter MaglianiStefania ContiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Luciano Polonelli Tecla Ciociola Martina Sperindè Laura Giovati Tiziana D’Adda Serena Galati Luiz R. Travassos Walter Magliani Stefania Conti Fungicidal activity of peptides encoded by immunoglobulin genes
description	Abstract Evidence from previous works disclosed the antimicrobial, antiviral, anti-tumour and/or immunomodulatory activity exerted, through different mechanisms of action, by peptides expressed in the complementarity-determining regions or even in the constant region of antibodies, independently from their specificity and isotype. Presently, we report the selection, from available databases, of peptide sequences encoded by immunoglobulin genes for the evaluation of their potential biological activities. Synthetic peptides representing the translated products of J lambda and J heavy genes proved to act in vitro against pathogenic fungi, entering yeast cells and causing their death, and exerted a therapeutic effect in a Galleria mellonella model of infection by Candida albicans. No haemolytic, cytotoxic and genotoxic effects were observed on mammalian cells. These findings raise the hypothesis that antibodies could be the evolutionary result of the adaptive combination of gene products ancestrally devoted to innate antimicrobial immunity.
format	article
author	Luciano Polonelli Tecla Ciociola Martina Sperindè Laura Giovati Tiziana D’Adda Serena Galati Luiz R. Travassos Walter Magliani Stefania Conti
author_facet	Luciano Polonelli Tecla Ciociola Martina Sperindè Laura Giovati Tiziana D’Adda Serena Galati Luiz R. Travassos Walter Magliani Stefania Conti
author_sort	Luciano Polonelli
title	Fungicidal activity of peptides encoded by immunoglobulin genes
title_short	Fungicidal activity of peptides encoded by immunoglobulin genes
title_full	Fungicidal activity of peptides encoded by immunoglobulin genes
title_fullStr	Fungicidal activity of peptides encoded by immunoglobulin genes
title_full_unstemmed	Fungicidal activity of peptides encoded by immunoglobulin genes
title_sort	fungicidal activity of peptides encoded by immunoglobulin genes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/353538c1f54249c5af512a70da48e7df
work_keys_str_mv	AT lucianopolonelli fungicidalactivityofpeptidesencodedbyimmunoglobulingenes AT teclaciociola fungicidalactivityofpeptidesencodedbyimmunoglobulingenes AT martinasperinde fungicidalactivityofpeptidesencodedbyimmunoglobulingenes AT lauragiovati fungicidalactivityofpeptidesencodedbyimmunoglobulingenes AT tizianadadda fungicidalactivityofpeptidesencodedbyimmunoglobulingenes AT serenagalati fungicidalactivityofpeptidesencodedbyimmunoglobulingenes AT luizrtravassos fungicidalactivityofpeptidesencodedbyimmunoglobulingenes AT waltermagliani fungicidalactivityofpeptidesencodedbyimmunoglobulingenes AT stefaniaconti fungicidalactivityofpeptidesencodedbyimmunoglobulingenes
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Fungicidal activity of peptides encoded by immunoglobulin genes

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