Macular neovascularization in eyes with pachydrusen

Abstract The natural history and clinical significance of pachydrusen is unclear. This study aims to compare the longitudinal changes of eyes with pachydrusen and soft drusen and progression to exudative macular neovascularisation (MNV). Patients with a diagnosis of MNV in one eye only and the fello...

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Autores principales:	Kelvin Yi Chong Teo, Kai Xiong Cheong, Ricardo Ong, Haslina Hamzah, Yasuo Yanagi, Tien Yin Wong, Usha Chakravarthy, Chui Ming Gemmy Cheung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/35370a34ca6743838b3eb099ba40e8d2
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spelling	oai:doaj.org-article:35370a34ca6743838b3eb099ba40e8d22021-12-02T14:15:53ZMacular neovascularization in eyes with pachydrusen10.1038/s41598-021-87083-42045-2322https://doaj.org/article/35370a34ca6743838b3eb099ba40e8d22021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87083-4https://doaj.org/toc/2045-2322Abstract The natural history and clinical significance of pachydrusen is unclear. This study aims to compare the longitudinal changes of eyes with pachydrusen and soft drusen and progression to exudative macular neovascularisation (MNV). Patients with a diagnosis of MNV in one eye only and the fellow eye was selected as the study eye. Study eyes were required to have pachydrusen or soft drusen on fundus photographs and follow up of at least 2 years or until exudative MNV occurred. Systematic grading was performed at baseline and change in drusen area and onset of exudative MNV recorded over the period of follow up. A total of 75 eyes from 75 patients (29 with pachydrusen and 46 with soft drusen) were included. There was no difference in the rate of progression to exudative MNV in the soft and pachydrusen groups (13.3% versus 24.1%, p = 0.38). Pachydrusen, as compared to soft drusen, was associated with polypoidal choroidal vasculopathy subtype (85.7% versus 16.7%, p < 0.01) and the location of exudation was co-localised with soft drusen but not with pachydrusen. There was a higher rate of increase in soft drusen area compared to pachydrusen area (27.7 ± 31.9%/year versus 8.7 ± 12.4%/year respectively, p < 0.01). We found no difference in the proportion of eyes that developed exudative MNV in this study however characterisation of drusen evolution patterns revealed a strong association with exudative MNV subtype.Kelvin Yi Chong TeoKai Xiong CheongRicardo OngHaslina HamzahYasuo YanagiTien Yin WongUsha ChakravarthyChui Ming Gemmy CheungNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kelvin Yi Chong Teo Kai Xiong Cheong Ricardo Ong Haslina Hamzah Yasuo Yanagi Tien Yin Wong Usha Chakravarthy Chui Ming Gemmy Cheung Macular neovascularization in eyes with pachydrusen
description	Abstract The natural history and clinical significance of pachydrusen is unclear. This study aims to compare the longitudinal changes of eyes with pachydrusen and soft drusen and progression to exudative macular neovascularisation (MNV). Patients with a diagnosis of MNV in one eye only and the fellow eye was selected as the study eye. Study eyes were required to have pachydrusen or soft drusen on fundus photographs and follow up of at least 2 years or until exudative MNV occurred. Systematic grading was performed at baseline and change in drusen area and onset of exudative MNV recorded over the period of follow up. A total of 75 eyes from 75 patients (29 with pachydrusen and 46 with soft drusen) were included. There was no difference in the rate of progression to exudative MNV in the soft and pachydrusen groups (13.3% versus 24.1%, p = 0.38). Pachydrusen, as compared to soft drusen, was associated with polypoidal choroidal vasculopathy subtype (85.7% versus 16.7%, p < 0.01) and the location of exudation was co-localised with soft drusen but not with pachydrusen. There was a higher rate of increase in soft drusen area compared to pachydrusen area (27.7 ± 31.9%/year versus 8.7 ± 12.4%/year respectively, p < 0.01). We found no difference in the proportion of eyes that developed exudative MNV in this study however characterisation of drusen evolution patterns revealed a strong association with exudative MNV subtype.
format	article
author	Kelvin Yi Chong Teo Kai Xiong Cheong Ricardo Ong Haslina Hamzah Yasuo Yanagi Tien Yin Wong Usha Chakravarthy Chui Ming Gemmy Cheung
author_facet	Kelvin Yi Chong Teo Kai Xiong Cheong Ricardo Ong Haslina Hamzah Yasuo Yanagi Tien Yin Wong Usha Chakravarthy Chui Ming Gemmy Cheung
author_sort	Kelvin Yi Chong Teo
title	Macular neovascularization in eyes with pachydrusen
title_short	Macular neovascularization in eyes with pachydrusen
title_full	Macular neovascularization in eyes with pachydrusen
title_fullStr	Macular neovascularization in eyes with pachydrusen
title_full_unstemmed	Macular neovascularization in eyes with pachydrusen
title_sort	macular neovascularization in eyes with pachydrusen
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/35370a34ca6743838b3eb099ba40e8d2
work_keys_str_mv	AT kelvinyichongteo macularneovascularizationineyeswithpachydrusen AT kaixiongcheong macularneovascularizationineyeswithpachydrusen AT ricardoong macularneovascularizationineyeswithpachydrusen AT haslinahamzah macularneovascularizationineyeswithpachydrusen AT yasuoyanagi macularneovascularizationineyeswithpachydrusen AT tienyinwong macularneovascularizationineyeswithpachydrusen AT ushachakravarthy macularneovascularizationineyeswithpachydrusen AT chuiminggemmycheung macularneovascularizationineyeswithpachydrusen
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Macular neovascularization in eyes with pachydrusen

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