The Role of Neuropeptide Y in Adipocyte-Macrophage Crosstalk during High Fat Diet-Induced Adipose Inflammation and Liver Steatosis

Obesity is associated with an increased risk of non-alcoholic fatty liver disease (NAFLD), which is initiated by adipocyte-macrophage crosstalk. Among the possible molecules regulating this crosstalk, we focused on neuropeptide Y (NPY), which is known to be involved in hypothalamic appetite and adip...

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Autores principales:	Seongjoon Park, Toshimitsu Komatsu, Hiroko Hayashi, Ryoichi Mori, Isao Shimokawa
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	obesity fatty liver neuropeptide Y macrophage brown adipose tissue Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/353898b62f5a4fc3903692e1da97eab7
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spelling	oai:doaj.org-article:353898b62f5a4fc3903692e1da97eab72021-11-25T16:51:37ZThe Role of Neuropeptide Y in Adipocyte-Macrophage Crosstalk during High Fat Diet-Induced Adipose Inflammation and Liver Steatosis10.3390/biomedicines91117392227-9059https://doaj.org/article/353898b62f5a4fc3903692e1da97eab72021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1739https://doaj.org/toc/2227-9059Obesity is associated with an increased risk of non-alcoholic fatty liver disease (NAFLD), which is initiated by adipocyte-macrophage crosstalk. Among the possible molecules regulating this crosstalk, we focused on neuropeptide Y (NPY), which is known to be involved in hypothalamic appetite and adipose tissue inflammation and metabolism. In this study, the NPY<sup>−/−</sup> mice showed a marked decrease in body weight and adiposity, and lower free fatty acid and adipose inflammation without food intake alteration during a high fat diet (HFD). Moreover, NPY deficiency increased the thermogenic genes expression in brown adipose tissue. Notably, NPY-mRNA expression was upregulated in macrophages from the HFD mice compared to that from the mice on a standard diet. The NPY-mRNA expression also positively correlated with the liver mass/body weight ratio. NPY deletion alleviated HFD-induced adipose inflammation and liver steatosis. Hence, our findings point toward a novel intracellular mechanism of NPY in the regulation of adipocyte-macrophage crosstalk and highlight NPY antagonism as a promising target for therapeutic approaches against obesity and NAFLD.Seongjoon ParkToshimitsu KomatsuHiroko HayashiRyoichi MoriIsao ShimokawaMDPI AGarticleobesityfatty liverneuropeptide Ymacrophagebrown adipose tissueBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1739, p 1739 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	obesity fatty liver neuropeptide Y macrophage brown adipose tissue Biology (General) QH301-705.5
spellingShingle	obesity fatty liver neuropeptide Y macrophage brown adipose tissue Biology (General) QH301-705.5 Seongjoon Park Toshimitsu Komatsu Hiroko Hayashi Ryoichi Mori Isao Shimokawa The Role of Neuropeptide Y in Adipocyte-Macrophage Crosstalk during High Fat Diet-Induced Adipose Inflammation and Liver Steatosis
description	Obesity is associated with an increased risk of non-alcoholic fatty liver disease (NAFLD), which is initiated by adipocyte-macrophage crosstalk. Among the possible molecules regulating this crosstalk, we focused on neuropeptide Y (NPY), which is known to be involved in hypothalamic appetite and adipose tissue inflammation and metabolism. In this study, the NPY<sup>−/−</sup> mice showed a marked decrease in body weight and adiposity, and lower free fatty acid and adipose inflammation without food intake alteration during a high fat diet (HFD). Moreover, NPY deficiency increased the thermogenic genes expression in brown adipose tissue. Notably, NPY-mRNA expression was upregulated in macrophages from the HFD mice compared to that from the mice on a standard diet. The NPY-mRNA expression also positively correlated with the liver mass/body weight ratio. NPY deletion alleviated HFD-induced adipose inflammation and liver steatosis. Hence, our findings point toward a novel intracellular mechanism of NPY in the regulation of adipocyte-macrophage crosstalk and highlight NPY antagonism as a promising target for therapeutic approaches against obesity and NAFLD.
format	article
author	Seongjoon Park Toshimitsu Komatsu Hiroko Hayashi Ryoichi Mori Isao Shimokawa
author_facet	Seongjoon Park Toshimitsu Komatsu Hiroko Hayashi Ryoichi Mori Isao Shimokawa
author_sort	Seongjoon Park
title	The Role of Neuropeptide Y in Adipocyte-Macrophage Crosstalk during High Fat Diet-Induced Adipose Inflammation and Liver Steatosis
title_short	The Role of Neuropeptide Y in Adipocyte-Macrophage Crosstalk during High Fat Diet-Induced Adipose Inflammation and Liver Steatosis
title_full	The Role of Neuropeptide Y in Adipocyte-Macrophage Crosstalk during High Fat Diet-Induced Adipose Inflammation and Liver Steatosis
title_fullStr	The Role of Neuropeptide Y in Adipocyte-Macrophage Crosstalk during High Fat Diet-Induced Adipose Inflammation and Liver Steatosis
title_full_unstemmed	The Role of Neuropeptide Y in Adipocyte-Macrophage Crosstalk during High Fat Diet-Induced Adipose Inflammation and Liver Steatosis
title_sort	role of neuropeptide y in adipocyte-macrophage crosstalk during high fat diet-induced adipose inflammation and liver steatosis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/353898b62f5a4fc3903692e1da97eab7
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The Role of Neuropeptide Y in Adipocyte-Macrophage Crosstalk during High Fat Diet-Induced Adipose Inflammation and Liver Steatosis

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