The Modulatory Influence of Plant-Derived Compounds on Human Keratinocyte Function

The plant kingdom is a rich source of secondary metabolites with numerous properties, including the potential to modify keratinocyte biology. Keratinocytes are important epithelial cells that play a protective role against various chemical, physical and biological stimuli, and participate in reactiv...

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Autores principales:	Anna Merecz-Sadowska, Przemysław Sitarek, Karolina Zajdel, Ewa Kucharska, Tomasz Kowalczyk, Radosław Zajdel
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	keratinocytes plants secondary metabolites ROS inflammation UV radiation Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/3538e7221e684b8888aea88e81380db8
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spelling	oai:doaj.org-article:3538e7221e684b8888aea88e81380db82021-11-25T17:57:14ZThe Modulatory Influence of Plant-Derived Compounds on Human Keratinocyte Function10.3390/ijms2222124881422-00671661-6596https://doaj.org/article/3538e7221e684b8888aea88e81380db82021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12488https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The plant kingdom is a rich source of secondary metabolites with numerous properties, including the potential to modify keratinocyte biology. Keratinocytes are important epithelial cells that play a protective role against various chemical, physical and biological stimuli, and participate in reactive oxygen scavenging and inflammation and wound healing processes. The epidermal cell response may be modulated by phytochemicals via changes in signal transduction pathways. Plant extracts and single secondary compounds can possess a high antioxidant capacity and may suppress reactive oxygen species release, inhibit pro-apoptotic proteins and apoptosis and activate antioxidant enzymes in keratinocytes. Moreover, selected plant extracts and single compounds also exhibit anti-inflammatory properties and exposure may result in limited production of adhesion molecules, pro-inflammatory cytokines and chemokines in keratinocytes. In addition, plant extracts and single compounds may promote keratinocyte motility and proliferation via the regulation of growth factor production and enhance wound healing. While such plant compounds may modulate keratinocyte functions, further in vitro and in vivo studies are needed on their mechanisms of action, and more specific toxicity and clinical studies are needed to ensure their effectiveness and safety for use on human skin.Anna Merecz-SadowskaPrzemysław SitarekKarolina ZajdelEwa KucharskaTomasz KowalczykRadosław ZajdelMDPI AGarticlekeratinocytesplantssecondary metabolitesROSinflammationUV radiationBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12488, p 12488 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	keratinocytes plants secondary metabolites ROS inflammation UV radiation Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	keratinocytes plants secondary metabolites ROS inflammation UV radiation Biology (General) QH301-705.5 Chemistry QD1-999 Anna Merecz-Sadowska Przemysław Sitarek Karolina Zajdel Ewa Kucharska Tomasz Kowalczyk Radosław Zajdel The Modulatory Influence of Plant-Derived Compounds on Human Keratinocyte Function
description	The plant kingdom is a rich source of secondary metabolites with numerous properties, including the potential to modify keratinocyte biology. Keratinocytes are important epithelial cells that play a protective role against various chemical, physical and biological stimuli, and participate in reactive oxygen scavenging and inflammation and wound healing processes. The epidermal cell response may be modulated by phytochemicals via changes in signal transduction pathways. Plant extracts and single secondary compounds can possess a high antioxidant capacity and may suppress reactive oxygen species release, inhibit pro-apoptotic proteins and apoptosis and activate antioxidant enzymes in keratinocytes. Moreover, selected plant extracts and single compounds also exhibit anti-inflammatory properties and exposure may result in limited production of adhesion molecules, pro-inflammatory cytokines and chemokines in keratinocytes. In addition, plant extracts and single compounds may promote keratinocyte motility and proliferation via the regulation of growth factor production and enhance wound healing. While such plant compounds may modulate keratinocyte functions, further in vitro and in vivo studies are needed on their mechanisms of action, and more specific toxicity and clinical studies are needed to ensure their effectiveness and safety for use on human skin.
format	article
author	Anna Merecz-Sadowska Przemysław Sitarek Karolina Zajdel Ewa Kucharska Tomasz Kowalczyk Radosław Zajdel
author_facet	Anna Merecz-Sadowska Przemysław Sitarek Karolina Zajdel Ewa Kucharska Tomasz Kowalczyk Radosław Zajdel
author_sort	Anna Merecz-Sadowska
title	The Modulatory Influence of Plant-Derived Compounds on Human Keratinocyte Function
title_short	The Modulatory Influence of Plant-Derived Compounds on Human Keratinocyte Function
title_full	The Modulatory Influence of Plant-Derived Compounds on Human Keratinocyte Function
title_fullStr	The Modulatory Influence of Plant-Derived Compounds on Human Keratinocyte Function
title_full_unstemmed	The Modulatory Influence of Plant-Derived Compounds on Human Keratinocyte Function
title_sort	modulatory influence of plant-derived compounds on human keratinocyte function
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3538e7221e684b8888aea88e81380db8
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The Modulatory Influence of Plant-Derived Compounds on Human Keratinocyte Function

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