Chromatin marks shape mutation landscape at early stage of cancer progression

Cancer: Chromatin marks underlie mutations for early cancer progression Environmental insults that change how DNA is packaged could lead to mutations responsible for the earliest stages of cancer. Hwajin Lee and colleagues at Seoul National University analyzed whole-genome sequencing data from preca...

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Autores principales:	Kyungsik Ha, Hong-Gee Kim, Hwajin Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Genetics QH426-470
Acceso en línea:	https://doaj.org/article/353b2c96211f42c1920c8d2c335dd5e8
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spelling	oai:doaj.org-article:353b2c96211f42c1920c8d2c335dd5e82021-12-02T11:42:12ZChromatin marks shape mutation landscape at early stage of cancer progression10.1038/s41525-017-0010-y2056-7944https://doaj.org/article/353b2c96211f42c1920c8d2c335dd5e82017-04-01T00:00:00Zhttps://doi.org/10.1038/s41525-017-0010-yhttps://doaj.org/toc/2056-7944Cancer: Chromatin marks underlie mutations for early cancer progression Environmental insults that change how DNA is packaged could lead to mutations responsible for the earliest stages of cancer. Hwajin Lee and colleagues at Seoul National University analyzed whole-genome sequencing data from precancerous tissues (B-cell and esophagus) and the matching cancer types (B-cell leukemia and esophageal cancer) from 173 individuals. They cross checked the mutational profiles against the epigenetic features that shape how DNA is wound into chromosomes, and found that these chromatin marks serve a central role in driving the overall mutation landscape. The authors suggest that gastric acid reflux, which is known to cause a precancerous condition known as Barrett’s esophagus, could be shifting the esophageal cells to become more stomach-like, and the resulting change in chromatin features might be triggering major mutation accumulations that affect subsequent cancer progression.Kyungsik HaHong-Gee KimHwajin LeeNature PortfolioarticleMedicineRGeneticsQH426-470ENnpj Genomic Medicine, Vol 2, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Genetics QH426-470
spellingShingle	Medicine R Genetics QH426-470 Kyungsik Ha Hong-Gee Kim Hwajin Lee Chromatin marks shape mutation landscape at early stage of cancer progression
description	Cancer: Chromatin marks underlie mutations for early cancer progression Environmental insults that change how DNA is packaged could lead to mutations responsible for the earliest stages of cancer. Hwajin Lee and colleagues at Seoul National University analyzed whole-genome sequencing data from precancerous tissues (B-cell and esophagus) and the matching cancer types (B-cell leukemia and esophageal cancer) from 173 individuals. They cross checked the mutational profiles against the epigenetic features that shape how DNA is wound into chromosomes, and found that these chromatin marks serve a central role in driving the overall mutation landscape. The authors suggest that gastric acid reflux, which is known to cause a precancerous condition known as Barrett’s esophagus, could be shifting the esophageal cells to become more stomach-like, and the resulting change in chromatin features might be triggering major mutation accumulations that affect subsequent cancer progression.
format	article
author	Kyungsik Ha Hong-Gee Kim Hwajin Lee
author_facet	Kyungsik Ha Hong-Gee Kim Hwajin Lee
author_sort	Kyungsik Ha
title	Chromatin marks shape mutation landscape at early stage of cancer progression
title_short	Chromatin marks shape mutation landscape at early stage of cancer progression
title_full	Chromatin marks shape mutation landscape at early stage of cancer progression
title_fullStr	Chromatin marks shape mutation landscape at early stage of cancer progression
title_full_unstemmed	Chromatin marks shape mutation landscape at early stage of cancer progression
title_sort	chromatin marks shape mutation landscape at early stage of cancer progression
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/353b2c96211f42c1920c8d2c335dd5e8
work_keys_str_mv	AT kyungsikha chromatinmarksshapemutationlandscapeatearlystageofcancerprogression AT honggeekim chromatinmarksshapemutationlandscapeatearlystageofcancerprogression AT hwajinlee chromatinmarksshapemutationlandscapeatearlystageofcancerprogression
_version_	1718395333687377920

Chromatin marks shape mutation landscape at early stage of cancer progression

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