A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein
Respiratory syncytial virus (RSV) is a leading cause of infant hospitalization. Here, the authors isolate a human monoclonal antibody that binds to a highly conserved epitope on the RSV fusion protein, neutralizes RSV A and B subtypes equipotently and is protective in the cotton rat model.
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Nature Portfolio
2019
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oai:doaj.org-article:353ee58e3241465cbd5aae22b7984ad32021-12-02T16:58:19ZA potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein10.1038/s41467-019-12137-12041-1723https://doaj.org/article/353ee58e3241465cbd5aae22b7984ad32019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12137-1https://doaj.org/toc/2041-1723Respiratory syncytial virus (RSV) is a leading cause of infant hospitalization. Here, the authors isolate a human monoclonal antibody that binds to a highly conserved epitope on the RSV fusion protein, neutralizes RSV A and B subtypes equipotently and is protective in the cotton rat model.Aimin TangZhifeng ChenKara S. CoxHua-Poo SuCheryl CallahanArthur FridmanLan ZhangSangita B. PatelPedro J. CejasRyan SwoyerSinoeun TouchMichael P. CitronDhanasekaran GovindarajanBin LuoMichael EddinsJohn C. ReidStephen M. SoissonJennifer GalliDai WangZhiyun WenGwendolyn J. HeideckerDanilo R. CasimiroDaniel J. DiStefanoKalpit A. VoraNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Aimin Tang Zhifeng Chen Kara S. Cox Hua-Poo Su Cheryl Callahan Arthur Fridman Lan Zhang Sangita B. Patel Pedro J. Cejas Ryan Swoyer Sinoeun Touch Michael P. Citron Dhanasekaran Govindarajan Bin Luo Michael Eddins John C. Reid Stephen M. Soisson Jennifer Galli Dai Wang Zhiyun Wen Gwendolyn J. Heidecker Danilo R. Casimiro Daniel J. DiStefano Kalpit A. Vora A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein |
| description |
Respiratory syncytial virus (RSV) is a leading cause of infant hospitalization. Here, the authors isolate a human monoclonal antibody that binds to a highly conserved epitope on the RSV fusion protein, neutralizes RSV A and B subtypes equipotently and is protective in the cotton rat model. |
| format |
article |
| author |
Aimin Tang Zhifeng Chen Kara S. Cox Hua-Poo Su Cheryl Callahan Arthur Fridman Lan Zhang Sangita B. Patel Pedro J. Cejas Ryan Swoyer Sinoeun Touch Michael P. Citron Dhanasekaran Govindarajan Bin Luo Michael Eddins John C. Reid Stephen M. Soisson Jennifer Galli Dai Wang Zhiyun Wen Gwendolyn J. Heidecker Danilo R. Casimiro Daniel J. DiStefano Kalpit A. Vora |
| author_facet |
Aimin Tang Zhifeng Chen Kara S. Cox Hua-Poo Su Cheryl Callahan Arthur Fridman Lan Zhang Sangita B. Patel Pedro J. Cejas Ryan Swoyer Sinoeun Touch Michael P. Citron Dhanasekaran Govindarajan Bin Luo Michael Eddins John C. Reid Stephen M. Soisson Jennifer Galli Dai Wang Zhiyun Wen Gwendolyn J. Heidecker Danilo R. Casimiro Daniel J. DiStefano Kalpit A. Vora |
| author_sort |
Aimin Tang |
| title |
A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein |
| title_short |
A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein |
| title_full |
A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein |
| title_fullStr |
A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein |
| title_full_unstemmed |
A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein |
| title_sort |
potent broadly neutralizing human rsv antibody targets conserved site iv of the fusion glycoprotein |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/353ee58e3241465cbd5aae22b7984ad3 |
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