Increased Visit-to-Visit Liver Enzyme Variability Is Associated with Incident Diabetes: A Community-Based 12-Year Prospective Cohort Study

Background Fatty liver and/or increased liver enzyme values have been reported to be associated with incident diabetes. We sought to determine whether increased visit-to-visit liver enzyme variability is associated with incident diabetes. Methods Study participants were recruited from the Korean Gen...

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Autores principales:	Kyuhoon Bang, Ji Eun Jun, In-Kyung Jeong, Kyu Jeung Ahn, Ho Yeon Chung, You-Cheol Hwang
Formato:	article
Lenguaje:	EN
Publicado:	Korean Diabetes Association 2021
Materias:	alanine transaminase aspartate aminotransferases biological variation cohort studies diabetes mellitus, type 2 korea Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/353fd861e4ec46d8be049e89f77cb83a
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spelling	oai:doaj.org-article:353fd861e4ec46d8be049e89f77cb83a2021-12-01T05:07:51ZIncreased Visit-to-Visit Liver Enzyme Variability Is Associated with Incident Diabetes: A Community-Based 12-Year Prospective Cohort Study2233-60792233-608710.4093/dmj.2020.0208https://doaj.org/article/353fd861e4ec46d8be049e89f77cb83a2021-11-01T00:00:00Zhttp://www.e-dmj.org/upload/pdf/dmj-2020-0208.pdfhttps://doaj.org/toc/2233-6079https://doaj.org/toc/2233-6087Background Fatty liver and/or increased liver enzyme values have been reported to be associated with incident diabetes. We sought to determine whether increased visit-to-visit liver enzyme variability is associated with incident diabetes. Methods Study participants were recruited from the Korean Genome and Epidemiologic Study (KoGES). A total of 4,151 people aged 40 to 69 years was recruited and tested every 2 years for up to 12 years. Visit-to-visit aspartate aminotransferase (AST) and alanine aminotransferase (ALT) variability was evaluated in first the 6-year period through the use of various variability measurements: standard deviation (SD), average successive variability, coefficient of variation (CV), and variation independent of mean (VIM). Oral glucose tolerance test was performed at every visit. Results During the 6-year follow-up appointments, 13.0% (538/4,151) of people developed incident diabetes. Visit-to-visit AST variability was associated with an increased risk of diabetes independent of conventional risk factors for diabetes (hazard ratio per 1-SD increment [95% confidence interval]: 1.06 [1.00 to 1.11], 1.12 [1.04 to 1.21], and 1.13 [1.04 to 1.22] for SD, CV, and VIM, respectively; all P<0.05); however, no such associations were observed in the visit-to-visit ALT variability. According to alcohol consumption status, both AST and ALT variability were independent predictors for incident diabetes in subjects with heavy alcohol consumption; however, neither AST nor ALT variability was associated with diabetes risk in subjects who did not drink alcohol heavily. Conclusion Visit-to-visit liver enzyme variability is an independent predictor of incident diabetes. Such association was more evident in those who consumed significant amounts of alcohol.Kyuhoon BangJi Eun JunIn-Kyung JeongKyu Jeung AhnHo Yeon ChungYou-Cheol HwangKorean Diabetes Associationarticlealanine transaminaseaspartate aminotransferasesbiological variationcohort studiesdiabetes mellitus, type 2koreaDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENDiabetes & Metabolism Journal, Vol 45, Iss 6, Pp 890-898 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	alanine transaminase aspartate aminotransferases biological variation cohort studies diabetes mellitus, type 2 korea Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	alanine transaminase aspartate aminotransferases biological variation cohort studies diabetes mellitus, type 2 korea Diseases of the endocrine glands. Clinical endocrinology RC648-665 Kyuhoon Bang Ji Eun Jun In-Kyung Jeong Kyu Jeung Ahn Ho Yeon Chung You-Cheol Hwang Increased Visit-to-Visit Liver Enzyme Variability Is Associated with Incident Diabetes: A Community-Based 12-Year Prospective Cohort Study
description	Background Fatty liver and/or increased liver enzyme values have been reported to be associated with incident diabetes. We sought to determine whether increased visit-to-visit liver enzyme variability is associated with incident diabetes. Methods Study participants were recruited from the Korean Genome and Epidemiologic Study (KoGES). A total of 4,151 people aged 40 to 69 years was recruited and tested every 2 years for up to 12 years. Visit-to-visit aspartate aminotransferase (AST) and alanine aminotransferase (ALT) variability was evaluated in first the 6-year period through the use of various variability measurements: standard deviation (SD), average successive variability, coefficient of variation (CV), and variation independent of mean (VIM). Oral glucose tolerance test was performed at every visit. Results During the 6-year follow-up appointments, 13.0% (538/4,151) of people developed incident diabetes. Visit-to-visit AST variability was associated with an increased risk of diabetes independent of conventional risk factors for diabetes (hazard ratio per 1-SD increment [95% confidence interval]: 1.06 [1.00 to 1.11], 1.12 [1.04 to 1.21], and 1.13 [1.04 to 1.22] for SD, CV, and VIM, respectively; all P<0.05); however, no such associations were observed in the visit-to-visit ALT variability. According to alcohol consumption status, both AST and ALT variability were independent predictors for incident diabetes in subjects with heavy alcohol consumption; however, neither AST nor ALT variability was associated with diabetes risk in subjects who did not drink alcohol heavily. Conclusion Visit-to-visit liver enzyme variability is an independent predictor of incident diabetes. Such association was more evident in those who consumed significant amounts of alcohol.
format	article
author	Kyuhoon Bang Ji Eun Jun In-Kyung Jeong Kyu Jeung Ahn Ho Yeon Chung You-Cheol Hwang
author_facet	Kyuhoon Bang Ji Eun Jun In-Kyung Jeong Kyu Jeung Ahn Ho Yeon Chung You-Cheol Hwang
author_sort	Kyuhoon Bang
title	Increased Visit-to-Visit Liver Enzyme Variability Is Associated with Incident Diabetes: A Community-Based 12-Year Prospective Cohort Study
title_short	Increased Visit-to-Visit Liver Enzyme Variability Is Associated with Incident Diabetes: A Community-Based 12-Year Prospective Cohort Study
title_full	Increased Visit-to-Visit Liver Enzyme Variability Is Associated with Incident Diabetes: A Community-Based 12-Year Prospective Cohort Study
title_fullStr	Increased Visit-to-Visit Liver Enzyme Variability Is Associated with Incident Diabetes: A Community-Based 12-Year Prospective Cohort Study
title_full_unstemmed	Increased Visit-to-Visit Liver Enzyme Variability Is Associated with Incident Diabetes: A Community-Based 12-Year Prospective Cohort Study
title_sort	increased visit-to-visit liver enzyme variability is associated with incident diabetes: a community-based 12-year prospective cohort study
publisher	Korean Diabetes Association
publishDate	2021
url	https://doaj.org/article/353fd861e4ec46d8be049e89f77cb83a
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Increased Visit-to-Visit Liver Enzyme Variability Is Associated with Incident Diabetes: A Community-Based 12-Year Prospective Cohort Study

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