YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells

YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells

Fibroblastic reticular cells (FRC) are important for lymph node (LN) structure and function. Here the authors show that the YAP/TAZ complex downstream of Hippo signalling regulates FRC commitment and maturation, with YAP/TAZ deficiency impairing FRC differentiation, while hyperactivation of YAZ/TAZ...

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Autores principales: Sung Yong Choi, Hosung Bae, Sun-Hye Jeong, Intae Park, Hyunsoo Cho, Seon Pyo Hong, Da-Hye Lee, Choong-kun Lee, Jin-Sung Park, Sang Heon Suh, Jeongwoon Choi, Myung Jin Yang, Jeon Yeob Jang, Lucas Onder, Jeong Hwan Moon, Han-Sin Jeong, Ralf H. Adams, Jin-Man Kim, Burkhard Ludewig, Joo-Hye Song, Dae-Sik Lim, Gou Young Koh
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/354526f25abf44f89bb47da409f5948a
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spelling oai:doaj.org-article:354526f25abf44f89bb47da409f5948a2021-12-02T17:33:13ZYAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells10.1038/s41467-020-14293-12041-1723https://doaj.org/article/354526f25abf44f89bb47da409f5948a2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14293-1https://doaj.org/toc/2041-1723Fibroblastic reticular cells (FRC) are important for lymph node (LN) structure and function. Here the authors show that the YAP/TAZ complex downstream of Hippo signalling regulates FRC commitment and maturation, with YAP/TAZ deficiency impairing FRC differentiation, while hyperactivation of YAZ/TAZ inducing myofibroblastic FRCs and LN fibrosis.Sung Yong ChoiHosung BaeSun-Hye JeongIntae ParkHyunsoo ChoSeon Pyo HongDa-Hye LeeChoong-kun LeeJin-Sung ParkSang Heon SuhJeongwoon ChoiMyung Jin YangJeon Yeob JangLucas OnderJeong Hwan MoonHan-Sin JeongRalf H. AdamsJin-Man KimBurkhard LudewigJoo-Hye SongDae-Sik LimGou Young KohNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sung Yong Choi
Hosung Bae
Sun-Hye Jeong
Intae Park
Hyunsoo Cho
Seon Pyo Hong
Da-Hye Lee
Choong-kun Lee
Jin-Sung Park
Sang Heon Suh
Jeongwoon Choi
Myung Jin Yang
Jeon Yeob Jang
Lucas Onder
Jeong Hwan Moon
Han-Sin Jeong
Ralf H. Adams
Jin-Man Kim
Burkhard Ludewig
Joo-Hye Song
Dae-Sik Lim
Gou Young Koh
YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells
description Fibroblastic reticular cells (FRC) are important for lymph node (LN) structure and function. Here the authors show that the YAP/TAZ complex downstream of Hippo signalling regulates FRC commitment and maturation, with YAP/TAZ deficiency impairing FRC differentiation, while hyperactivation of YAZ/TAZ inducing myofibroblastic FRCs and LN fibrosis.
format article
author Sung Yong Choi
Hosung Bae
Sun-Hye Jeong
Intae Park
Hyunsoo Cho
Seon Pyo Hong
Da-Hye Lee
Choong-kun Lee
Jin-Sung Park
Sang Heon Suh
Jeongwoon Choi
Myung Jin Yang
Jeon Yeob Jang
Lucas Onder
Jeong Hwan Moon
Han-Sin Jeong
Ralf H. Adams
Jin-Man Kim
Burkhard Ludewig
Joo-Hye Song
Dae-Sik Lim
Gou Young Koh
author_facet Sung Yong Choi
Hosung Bae
Sun-Hye Jeong
Intae Park
Hyunsoo Cho
Seon Pyo Hong
Da-Hye Lee
Choong-kun Lee
Jin-Sung Park
Sang Heon Suh
Jeongwoon Choi
Myung Jin Yang
Jeon Yeob Jang
Lucas Onder
Jeong Hwan Moon
Han-Sin Jeong
Ralf H. Adams
Jin-Man Kim
Burkhard Ludewig
Joo-Hye Song
Dae-Sik Lim
Gou Young Koh
author_sort Sung Yong Choi
title YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells
title_short YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells
title_full YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells
title_fullStr YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells
title_full_unstemmed YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells
title_sort yap/taz direct commitment and maturation of lymph node fibroblastic reticular cells
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/354526f25abf44f89bb47da409f5948a
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