Clinico-expert diagnostics of gastrointestinal form of diabetic neuropathy

Aim. To estimate dynamics of secretory and motor-evacuational functions of the stomach in patients with type 1 diabetes mellitus and gastrointestinalform of diabetic neuropathy. Materials and methods. 32 patients with DM1 without gastrointestinal pathology allocated to different groups depending o...

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Autores principales:	Irina Alekseevna Kurnikova, Tatiana Evgen'evna Chernyshova, Irina Vladimirovna Gur'eva, Guzyal' Ilgisovna Kliment'eva
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2011
Materias:	diabetes mellitus diabetic vegetative neuropathy clinico-expert diagnostics gastroscintiography Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/354a37c45697473b9d8a6e000afed53c
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spelling	oai:doaj.org-article:354a37c45697473b9d8a6e000afed53c2021-11-14T09:00:16ZClinico-expert diagnostics of gastrointestinal form of diabetic neuropathy2072-03512072-037810.14341/2072-0351-5644https://doaj.org/article/354a37c45697473b9d8a6e000afed53c2011-06-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5644https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To estimate dynamics of secretory and motor-evacuational functions of the stomach in patients with type 1 diabetes mellitus and gastrointestinalform of diabetic neuropathy. Materials and methods. 32 patients with DM1 without gastrointestinal pathology allocated to different groups depending on DM duration (gr. 1 lessthan 10 yr, gr. 2 over 10 yr). Vegetative equilibrium was estimated from the Kerdo index, rehabilitative potential from its basic constituent (morphophysiologicalindex). The motor-evacuational function of the stomach was studied with the use of a scintillation gamma-chamber, the gastric secretoryfunction by pH measurements. Results. Half of the patients in gr 2 presented with hypersympathicotony. The frequency of hypertonic form of gastric tone increased with durationof DM while the acid-producing and evacuational functions of the stomach decreased (as estimated by pH-measurement and gastroscintiographyrespectively). The propulsive function most significantly decreased in the pyloric part. The efficacy of rehabilitation of diabetic patients with gastrointestinalform of diabetic neuropathy was much lower than in those with preserved vegetative function of the stomach. Conclusion. Impairment of evacuational function of the stomach and duodenum with DM1 duration may be a cause of unstable blood glucose level.Hypomotor dyskinesia of the upper gastrointestinal tract due to DM1 and deficit of parasympathetic innervation occurs more frequently in patientswith low rehabilitative potential. Functional changes in the gastrointestinal tract of DM1 patients do not depend on the quality of compensation ofmetabolic disorders but correlate (r=-0.39) with DM duration. It is concluded that the gastrointestinal form of diabetic neuropathy impairs rehabilitativepotential of fhe patients.Irina Alekseevna KurnikovaTatiana Evgen'evna ChernyshovaIrina Vladimirovna Gur'evaGuzyal' Ilgisovna Kliment'evaEndocrinology Research Centrearticlediabetes mellitusdiabetic vegetative neuropathyclinico-expert diagnosticsgastroscintiographyNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 14, Iss 2, Pp 94-97 (2011)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus diabetic vegetative neuropathy clinico-expert diagnostics gastroscintiography Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus diabetic vegetative neuropathy clinico-expert diagnostics gastroscintiography Nutritional diseases. Deficiency diseases RC620-627 Irina Alekseevna Kurnikova Tatiana Evgen'evna Chernyshova Irina Vladimirovna Gur'eva Guzyal' Ilgisovna Kliment'eva Clinico-expert diagnostics of gastrointestinal form of diabetic neuropathy
description	Aim. To estimate dynamics of secretory and motor-evacuational functions of the stomach in patients with type 1 diabetes mellitus and gastrointestinalform of diabetic neuropathy. Materials and methods. 32 patients with DM1 without gastrointestinal pathology allocated to different groups depending on DM duration (gr. 1 lessthan 10 yr, gr. 2 over 10 yr). Vegetative equilibrium was estimated from the Kerdo index, rehabilitative potential from its basic constituent (morphophysiologicalindex). The motor-evacuational function of the stomach was studied with the use of a scintillation gamma-chamber, the gastric secretoryfunction by pH measurements. Results. Half of the patients in gr 2 presented with hypersympathicotony. The frequency of hypertonic form of gastric tone increased with durationof DM while the acid-producing and evacuational functions of the stomach decreased (as estimated by pH-measurement and gastroscintiographyrespectively). The propulsive function most significantly decreased in the pyloric part. The efficacy of rehabilitation of diabetic patients with gastrointestinalform of diabetic neuropathy was much lower than in those with preserved vegetative function of the stomach. Conclusion. Impairment of evacuational function of the stomach and duodenum with DM1 duration may be a cause of unstable blood glucose level.Hypomotor dyskinesia of the upper gastrointestinal tract due to DM1 and deficit of parasympathetic innervation occurs more frequently in patientswith low rehabilitative potential. Functional changes in the gastrointestinal tract of DM1 patients do not depend on the quality of compensation ofmetabolic disorders but correlate (r=-0.39) with DM duration. It is concluded that the gastrointestinal form of diabetic neuropathy impairs rehabilitativepotential of fhe patients.
format	article
author	Irina Alekseevna Kurnikova Tatiana Evgen'evna Chernyshova Irina Vladimirovna Gur'eva Guzyal' Ilgisovna Kliment'eva
author_facet	Irina Alekseevna Kurnikova Tatiana Evgen'evna Chernyshova Irina Vladimirovna Gur'eva Guzyal' Ilgisovna Kliment'eva
author_sort	Irina Alekseevna Kurnikova
title	Clinico-expert diagnostics of gastrointestinal form of diabetic neuropathy
title_short	Clinico-expert diagnostics of gastrointestinal form of diabetic neuropathy
title_full	Clinico-expert diagnostics of gastrointestinal form of diabetic neuropathy
title_fullStr	Clinico-expert diagnostics of gastrointestinal form of diabetic neuropathy
title_full_unstemmed	Clinico-expert diagnostics of gastrointestinal form of diabetic neuropathy
title_sort	clinico-expert diagnostics of gastrointestinal form of diabetic neuropathy
publisher	Endocrinology Research Centre
publishDate	2011
url	https://doaj.org/article/354a37c45697473b9d8a6e000afed53c
work_keys_str_mv	AT irinaalekseevnakurnikova clinicoexpertdiagnosticsofgastrointestinalformofdiabeticneuropathy AT tatianaevgenevnachernyshova clinicoexpertdiagnosticsofgastrointestinalformofdiabeticneuropathy AT irinavladimirovnagureva clinicoexpertdiagnosticsofgastrointestinalformofdiabeticneuropathy AT guzyalilgisovnaklimenteva clinicoexpertdiagnosticsofgastrointestinalformofdiabeticneuropathy
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Clinico-expert diagnostics of gastrointestinal form of diabetic neuropathy

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